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Title:           Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate
Subject:         Nature Communications, doi:10.1038/s41467-024-45716-y
Keywords:        
Author:          Roshana Thambyrajah
Creator:         Springer
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     Item: 
      Title: Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell’fate
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        Title: Results
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        Children: 
         Item: 
          Title: Notch receptors and ligand proteins are dynamically expressed in the AGM subpopulations
          Destination: B1
         Item: 
          Title: Single cell RNA sequencing identifies different subpopulations of GFI1 + HE
          Destination: B2
         Item: 
          Title: High Notch transcriptional activity identifies a HSC-primed HE cluster and decreases with HSPC maturation
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         Item: 
          Title: JAG1 and NOTCH1 interactions accumulate in’IAHC
          Destination: B4
         Item: 
          Title: JAG1 and NOTCH1 interact in cis in’IAHC
          Destination: B5
         Item: 
          Title: Cis interaction between JAG1 and NOTCH1 reduces Notch activation in’IAHC
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         Item: 
          Title: NOTCH1-JAG1 interactions in cis inhibit lineage differentiation’genes
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         Item: 
          Title: NOTCH1-JAG1 interactions in cis is reduced upon RFNG knockdown
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        Title: Discussion
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       Item: 
        Title: Materials and Methods
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         Item: 
          Title: Mouse lines and animal’work
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         Item: 
          Title: Genotyping’PCR
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         Item: 
          Title: AGM dissection, single cell suspension
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         Item: 
          Title: cDNA generation and’qPCRs
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         Item: 
          Title: Single-cell RNA sequencing
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         Item: 
          Title: scRNASeq data analysis
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         Item: 
          Title: Immuno- histo-chemistry
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         Item: 
          Title: Intracellular FACS staining
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         Item: 
          Title: Proximity Ligation assay’(PLA)
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         Item: 
          Title: Nascent RNA capture’assay
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         Item: 
          Title: Nascent RNA capture- sample processing
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         Item: 
          Title: Nascent RNASeq data analysis
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         Item: 
          Title: Functional analysis
          Destination: B21
         Item: 
          Title: Ex vivo culture of AGMs with scramble or RFNG FANA-ASO
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         Item: 
          Title: Quantification and statistical analysis
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          Title: Reporting summary
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        Title: References
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        Title: Acknowledgements
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        Title: Author contributions
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       Item: 
        Title: Competing interests
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       Item: 
        Title: Additional information
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    Title: Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate
    Author: Roshana Thambyrajah
    Subject: Nature Communications, doi:10.1038/s41467-024-45716-y
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
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   Type: SHA-256