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Title:           Effect of aging on the human myometrium at single-cell resolution
Subject:         Nature Communications, doi:10.1038/s41467-024-45143-z
Keywords:        
Author:          Paula Punzon-Jimenez
Creator:         Springer
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      Title: Effect of aging on the human myometrium at single-cell resolution
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        Title: Results
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         Item: 
          Title: Single-cell atlas of the aging myometrium
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         Item: 
          Title: Endothelial dysfunction associated with’aging
          Destination: B2
         Item: 
          Title: Transcriptomic changes in aging myometrial fibroblasts
          Destination: B3
         Item: 
          Title: Less contractile and ion-conductive smooth muscle’cells
          Destination: B4
         Item: 
          Title: Age-related inflammation/ DNA damage in perivascular’cells
          Destination: B5
         Item: 
          Title: Monocytic dysfunction as a hallmark of the aging myometrium
          Destination: B6
         Item: 
          Title: Altered cell-to-cell communication in aging myometrium
          Destination: B7
         Item: 
          Title: The loss of signaling pathways accompanies myometrial’aging
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        Title: Discussion
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       Item: 
        Title: Methods
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        Children: 
         Item: 
          Title: Participant details
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         Item: 
          Title: Tissue collection and sample preparation
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         Item: 
          Title: Nuclei isolation for snRNA-seq from myometrial cell suspensions
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         Item: 
          Title: Single-cell capture, library preparation, and sequencing
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         Item: 
          Title: Spatial transcriptomics
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         Item: 
          Title: sc/snRNA-seq data processing and filtering
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         Item: 
          Title: Integration of single cells and single nuclei across conditions and clustering
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         Item: 
          Title: Tissue cell composition analysis and annotation of sc/snRNA-seq datasets
          Destination: B16
         Item: 
          Title: Analysis of differential cell abundances and gene expression between perimenopausal and postmenopausal myometria
          Destination: B17
         Item: 
          Title: Spatial transcriptomics data processing
          Destination: B18
         Item: 
          Title: Analysis of cell-cell communication
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         Item: 
          Title: Immunofluorescence of tissue sections
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         Item: 
          Title: Statistics & reproducibility
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         Item: 
          Title: Reporting summary
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        Title: Data availability
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        Title: References
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        Title: Acknowledgements
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        Title: Author contributions
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       Item: 
        Title: Competing interests
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   Type: CRC32
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