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Keywords: CD200 polymorphisms, multiple myeloma, immune checkpoint, bone marrow microenvironment, immune disfunction Author: Yolanda Gonzalez-Montes CreationDate: Tue Feb 20 04:47:56 2024 CET ModDate: Tue Feb 20 04:47:56 2024 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 1284565 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KENFNN+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 730 0 KENFNO+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 731 0 KENFNP+AdvPSA18C Type 1C WinAnsi yes yes no 732 0 KENFOA+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 733 0 KENFOB+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 734 0 KENFOC+AdvPSA323 Type 1C WinAnsi yes yes no 735 0 KENFPD+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 741 0 KENFPE+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 742 0 KENJFA+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 747 0 KENJKB+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 199 0 KENJLC+AdvOTd877c31c+21 Type 1C WinAnsi yes yes no 198 0 KENJJP+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 196 0 KENJKA+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 203 0 KENJNC+AdvOTd877c31c Type 1C WinAnsi yes yes no 208 0 KENJND+AdvTT749c1f5a.I Type 1C WinAnsi yes yes no 209 0 KENJNE+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 212 0 KENJOF+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 215 0 KENJOG+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 216 0 KENJPG+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 222 0 KENKCG+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 224 0 HelveticaNeueLTStd-Bd Type 1C WinAnsi yes no no 228 0 KENOCP+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 231 0 KEOEPH+AdvTT58d178b9+03 Type 1C Custom yes yes yes 237 0 KEOFAH+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 236 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-11-01 02:50:50 CET RepresentationInformation: 301943.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-10-31 09:43:43 CET Size: 1284565 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 807 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: CD200 genotype is associated with clinical outcome of patients with multiple myeloma Destination: bmark_457435504 Children: Item: Title: Introduction Destination: s1 Item: Title: Patients and methods Destination: s2 Children: Item: Title: Expression of CD200 in plasma cell and lymphocyte subsets populations Destination: s2_1 Item: Title: Genotype analysis Destination: s2_2 Item: Title: Statistical analyses Destination: s2_3 Item: Title: Results Destination: s3 Children: Item: Title: CD200 genotype distribution Destination: s3_1 Item: Title: Homogeneity between genotype groups Destination: s3_2 Item: Title: Flow cytometry CD200 expression Destination: s3_3 Item: Title: Correlation between CD200 genotype and progression to symptomatic multiple myeloma Destination: s3_4 Item: Title: CD200 genotype and clinical outcome after treatment of symptomatic multiple myeloma Destination: s3_5 Item: Title: Discussion Destination: s4 Item: Title: Data availability statement Destination: s5 Item: Title: Ethics statement Destination: s6 Item: Title: Author contributions Destination: s7 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Title: CD200 genotype is associated with clinical outcome of patients with multiple myeloma Author: Yolanda Gonzalez-Montes Subject: Immune dysfunction in patients with MM affects both the innate and adaptive immune system. 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Escoda Josep Sarrà Ana Garzó Natàlia Lloveras Beatriz Gómez Isabel Granada David Gallardo Immune dysfunction in patients with MM affects both the innate and adaptive immune system. Copyright © 2024 Gonzalez-Montes, Osca-Gelis, Rodriguez-Romanos, Villavicencio, González-Bártulos, Llopis, Clapes, Oriol, Sureda, Escoda, Sarrà, Garzó, Lloveras, Gómez, Granada and Gallardo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. CD200 genotype is associated with clinical outcome of patients with multiple myeloma CD200 polymorphisms multiple myeloma immune checkpoint bone marrow microenvironment immune disfunction CD200 polymorphisms, multiple myeloma, immune checkpoint, bone marrow microenvironment, immune disfunction True https://www.frontiersin.org/legal/copyright-statement 2024-02-20T11:47:56+08:00 2024-02-20T11:47:56+08:00 2024-02-20T11:47:56+08:00 uuid:875c9800-0904-4a7a-9f68-b958abdeabd9 uuid:f53444a1-07a8-4544-b76b-2a17ccdae6b4 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 221, 685, 516, 706 Annotation: Subtype: Link Rect: 221, 660, 540, 681 Annotation: Subtype: Link Rect: 221, 635, 444, 656 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 690, 125, 705 Annotation: Subtype: Link Rect: 60, 528, 146, 535 Annotation: Subtype: Link Rect: 49, 388, 159, 395 Annotation: Subtype: Link Rect: 49, 311, 195, 318 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