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Title:           3Dmapper: a command line tool for BioBank-scale mapping of variants to protein structures
Subject:         Doi: 10.1093/bioinformatics/btae171 Bioinformatics, 40, 4, 2024 Publication Date: 02/04/2024 Abstract Motivation The interpretation of genomic data is crucial to understand the molecular mechanisms of biological processes. Protein structures play a vital role in facilitating this interpretation by providing functional context to genetic coding variants. However, mapping genes to proteins is a tedious and error-prone task due to inconsistencies in data formats. Over the past two decades, numerous tools and databases have been developed to automatically map annotated positions and variants to protein structures. However, most of these tools are web-based and not well-suited for large-scale genomic data analysis.Results To address this issue, we introduce 3Dmapper, a stand-alone command-line tool developed in Python and R. It systematically maps annotated protein positions and variants to protein structures, providing a solution that is both efficient and reliable.Availability and implementation https://github.com/vicruiser/3Dmapper
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    Title: 3Dmapper: a command line tool for BioBank-scale mapping of variants to protein structures
    Subject: Doi: 10.1093/bioinformatics/btae171 Bioinformatics, 40, 4, 2024 Publication Date: 02/04/2024 Abstract Motivation The interpretation of genomic data is crucial to understand the molecular mechanisms of biological processes. Protein structures play a vital role in facilitating this interpretation by providing functional context to genetic coding variants. However, mapping genes to proteins is a tedious and error-prone task due to inconsistencies in data formats. Over the past two decades, numerous tools and databases have been developed to automatically map annotated positions and variants to protein structures. However, most of these tools are web-based and not well-suited for large-scale genomic data analysis.Results To address this issue, we introduce 3Dmapper, a stand-alone command-line tool developed in Python and R. It systematically maps annotated protein positions and variants to protein structures, providing a solution that is both efficient and reliable.Availability and implementation https://github.com/vicruiser/3Dmapper
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  Checksum: 7b8f69b9
   Type: CRC32
  Checksum: 76aaf0796bdc50e3a3a9981f65fafc8c
   Type: MD5
  Checksum: 32238880cc2baddb9e6f90d9a697009ee1b18618
   Type: SHA-1
  Checksum: baeb4e26c01ab94a6b06d0102595ce74d093ceb12df9f36aadd686d456057957
   Type: SHA-256