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studies unravels a sensitization to cytarabine-based chemotherapy through HIF pathway inhibition in AML leukemia stem cells Destination: mk:titleTitle1 Children: Item: Title: INTRODUCTION Destination: mk:titleH12 Item: Title: MATERIALS/SUBJECTS AND METHODS Destination: mk:titleH13 Children: Item: Title: Primary human cells Destination: mk:titleH24 Item: Title: Statistical analysis Destination: mk:titleH25 Item: Title: Data and code availability Destination: mk:titleH26 Item: Title: RESULTS Destination: mk:titleH17 Children: Item: Title: Hypoxia transcriptional signature clusters inv(16) AML subgroup Destination: mk:titleH28 Item: Title: Identification of human AML-LSCs using scRNA-seq Destination: mk:titleH29 Item: Title: Transcriptional characterization identifies key molecular features of the AML-LSCs Destination: mk:titleH210 Item: Title: Low expression of the hypoxia signature is detected in human AML-LSCs Destination: mk:titleH211 Item: Title: Paired Dx-REL analysis reveals patient-specific differential molecular features of the AML-LSCs Destination: mk:titleH212 Item: Title: Inhibition of the HIF pathway sensitizes AML-LSCs to chemotherapy in vitro Destination: mk:titleH213 Item: Title: Inhibition of the HIF pathway sensitizes AML-LSCs to chemotherapy in vivo Destination: mk:titleH214 Item: Title: DISCUSSION Destination: mk:titleH115 Item: Title: ACKNOWLEDGMENTS Destination: mk:titleH116 Item: Title: AUTHOR CONTRIBUTIONS Destination: mk:titleH117 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: mk:titleH118 Item: Title: DATA AVAILABILITY STATEMENT Destination: mk:titleH119 Item: Title: FUNDING Destination: mk:titleH120 Item: Title: ORCID Destination: mk:titleH121 Item: Title: SUPPORTING INFORMATION Destination: mk:titleH122 Item: Title: REFERENCES Destination: mk:titleH123 Info: Author: Subject: HemaSphere, doi:10.1002/hem3.45 Keywords: Creator: John Wiley & Sons CreationDate: Fri Feb 23 10:31:28 CET 2024 ModDate: Fri Feb 23 10:31:28 CET 2024 ID: 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