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HeadingJIMD_12723jimd12723-sec-0008 Item: Title: 3.3 Evolving phenotype Destination: HeadingJIMD_12723jimd12723-sec-0009 Item: Title: 3.4 Brain imaging Destination: HeadingJIMD_12723jimd12723-sec-0010 Item: Title: 3.5 Variants in ALDH5A1 Destination: HeadingJIMD_12723jimd12723-sec-0011 Item: Title: 3.6 In-silico analysis of missense variants Destination: HeadingJIMD_12723jimd12723-sec-0012 Item: Title: 3.7 Genotype/phenotype correlation Destination: HeadingJIMD_12723jimd12723-sec-0013 Item: Title: 3.8 Treatment approaches Destination: HeadingJIMD_12723jimd12723-sec-0014 Item: Title: 4 DISCUSSION Destination: HeadingJIMD_12723jimd12723-sec-0015 Item: Title: AUTHOR CONTRIBUTIONS Destination: HeadingJIMD_12723jimd12723-sec-0016 Item: Title: ACKNOWLEDGMENTS Destination: HeadingJIMD_12723jimd12723-sec-0017 Item: Title: FUNDING INFORMATION Destination: HeadingJIMD_12723jimd12723-sec-0018 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: HeadingJIMD_12723jimd12723-sec-0019 Children: 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