9dcebbb4cf800fd72c4717c926581bcc 302144.pdf 3cd9bb9660af59bc712e48e75c7762251b9491fd 302144.pdf 593cf469f1536ce032202c79e33f7940dc70e6b602a217e494eaa26742eb1784 302144.pdf Title: Impact of Epicardial Adipose Tissue on Infarct Size and Left Ventricular Systolic Function in Patients with Anterior ST-Segment Elevation Myocardial Infarction Subject: We aimed to assess the correlation of cardiovascular magnetic resonance (CMR)-derived epicardial adipose tissue (EAT) with infarct size (IS) and residual systolic function in ST-segment elevation myocardial infarction (STEMI). We enrolled patients discharged for a first anterior reperfused STEMI submitted to undergo CMR. EAT, left ventricular (LV) ejection fraction (LVEF), and IS were quantified at the 1-week (n = 221) and at 6-month CMR (n = 167). At 1-week CMR, mean EAT was31 13 mL/m2. Patients with high EAT volume (n = 72) showed larger 1-week IS. After adjustment, EAT extent was independently related to 1-week IS. In patients with large IS at 1 week (>30% of LV mass, n = 88), those with high EAT showed more preserved 6-month LVEF. This association persisted after adjustment and in a 1:1 propensity score-matched patient subset. Overall, EAT decreased at6 months. In patients with large IS, a greater reduction of EAT was associated with more preserved 6-month LVEF. In STEMI, a higher presence of EAT was associated with a larger IS. Nevertheless, in patients with large infarctions, high EAT and greater subsequent EAT reduction were linked to more preserved LVEF in the chronic phase. This dual and paradoxical effect of EAT fuels the need for further research in this field. Keywords: ST-segment elevation myocardial infarction; epicardial adipose tissue; cardiovascular magnetic resonance; infarct size; left ventricular ejection fraction Author: Jose Gavara, Hector Merenciano-Gonzalez, Jordi Llopis-Lorente, Tamara Molina-Garcia, Nerea Perez-Solé, Elena de Dios, Víctor Marcos-Garces, Jose V. Monmeneu, Maria P. Lopez-Lereu, Joaquim Canoves, Clara Bonanad, David Moratal, Julio Núñez, Antoni Bayés-Genis, Juan Sanchis, Francisco J. Chorro, Cesar Rios-Navarro and Vicente Bodí Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Wed Feb 7 15:28:13 2024 CET ModDate: Wed Feb 7 15:31:04 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3312566 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NBDQEL+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 THXAOD+VnURWPalladioL Type 1 Custom yes yes yes 16 0 BHXNPA+URWPalladioL-Bold Type 1 Custom yes yes yes 21 0 JUCVWN+URWPalladioL-Roma Type 1 Custom yes yes yes 27 0 FBKCJX+URWPalladioL-Ital Type 1 Custom yes yes yes 32 0 CZMDWU+CMSY10 Type 1 Builtin yes yes yes 37 0 BXZUUH+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 53 0 PELJAB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 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Rel. 1.12.4 (2023-03-16) LastModified: 2024-12-19 09:35:42 CET Size: 3312566 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 704 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Population Destination: subsection.2.1 Item: Title: Acquisition and Sequences of CMR Studies Destination: subsection.2.2 Item: Title: CMR Indices Quantification Destination: subsection.2.3 Item: Title: Variability of Measurements Destination: subsection.2.4 Item: Title: Endpoints and Follow-Up Destination: subsection.2.5 Item: Title: Statistical Analysis Destination: subsection.2.6 Item: Title: Results Destination: section.3 Children: Item: Title: Association of 1-Week EAT with IS Destination: subsection.3.1 Item: Title: Association of 1-Week EAT with 6-Month LVEF Destination: subsection.3.2 Item: Title: Dynamics of EAT and Association with 6-Month LVEF Destination: subsection.3.3 Item: Title: Discussion Destination: section.4 Children: Item: Title: Anatomy and Physiology of EAT Destination: subsection.4.1 Item: Title: EAT and IS Destination: subsection.4.2 Item: Title: Association of EAT with 6-Month LVEF Destination: subsection.4.3 Item: Title: EAT Dynamics Destination: subsection.4.4 Item: Title: Study Limitations Destination: subsection.4.5 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Impact of Epicardial Adipose Tissue on Infarct Size and Left Ventricular Systolic Function in Patients with Anterior ST-Segment Elevation Myocardial Infarction Author: Jose Gavara, Hector Merenciano-Gonzalez, Jordi Llopis-Lorente, Tamara Molina-Garcia, Nerea Perez-Solé, Elena de Dios, Víctor Marcos-Garces, Jose V. Monmeneu, Maria P. Lopez-Lereu, Joaquim Canoves, Clara Bonanad, David Moratal, Julio Núñez, Antoni Bayés-Genis, Juan Sanchis, Francisco J. Chorro, Cesar Rios-Navarro and Vicente Bodí Subject: We aimed to assess the correlation of cardiovascular magnetic resonance (CMR)-derived epicardial adipose tissue (EAT) with infarct size (IS) and residual systolic function in ST-segment elevation myocardial infarction (STEMI). We enrolled patients discharged for a first anterior reperfused STEMI submitted to undergo CMR. EAT, left ventricular (LV) ejection fraction (LVEF), and IS were quantified at the 1-week (n = 221) and at 6-month CMR (n = 167). At 1-week CMR, mean EAT was31 13 mL/m2. Patients with high EAT volume (n = 72) showed larger 1-week IS. After adjustment, EAT extent was independently related to 1-week IS. In patients with large IS at 1 week (>30% of LV mass, n = 88), those with high EAT showed more preserved 6-month LVEF. This association persisted after adjustment and in a 1:1 propensity score-matched patient subset. Overall, EAT decreased at6 months. In patients with large IS, a greater reduction of EAT was associated with more preserved 6-month LVEF. In STEMI, a higher presence of EAT was associated with a larger IS. Nevertheless, in patients with large infarctions, high EAT and greater subsequent EAT reduction were linked to more preserved LVEF in the chronic phase. This dual and paradoxical effect of EAT fuels the need for further research in this field. 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