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Title:           Very-Low-Level Viremia, Inflammatory Biomarkers, and Associated Baseline Variables: Three-Year Results of the Randomized TANGO Study
Subject:         DOI: 10.1093/ofid/ofad626; Open Forum Infectious Diseases, 11, 1, 2023-12-09.; Abstract:  Background: We compared proportions of participants with target detected, target not detected (TND), and elevated viral load (VL) and assessed baseline variables associated with week 144 inflammatory biomarker levels between dolutegravir-lamivudine (DTG/3TC) and tenofovir alafenamide–based regimens (TBRs) in the TANGO study (post hoc). Methods: TANGO is an open-label, multicenter, phase 3 study that randomized adults with VL <50 copies/mL to switch to once-daily fixed-dose DTG/3TC or continue TBR. At baseline and each study visit, the VL was measured. Elevated VL event frequencies were assessed, including “blips.” Interleukin 6, D-dimer, high-sensitivity C-reactive protein, soluble CD14, and soluble CD163 were measured at baseline and at week 144. Loge-transformed week 144 biomarker levels were compared between treatment groups using an analysis of covariance model adjusting for baseline variables. Result
Keywords:        2-drug regimen; dolutegravir-lamivudine; inflammation; integrase strand transfer inhibitor; virologic suppression
Author:          Ruolan Wang
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      Title: Very-Low-Level Viremia, Inflammatory Biomarkers, and Associated Baseline Variables: Three-Year Results of the Randomized TANGO Study
      Destination: head1
      Children: 
       Item: 
        Title: METHODS
        Destination: secofad626-s0
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         Item: 
          Title: Participants and Study Design
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         Item: 
          Title: Procedures
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         Item: 
          Title: Ethical Approval
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         Item: 
          Title: Patient Consent Statement
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         Item: 
          Title: Statistical Analysis
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       Item: 
        Title: RESULTS
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         Item: 
          Title: Study Participants
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         Item: 
          Title: VL Assessments
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         Item: 
          Title: Inflammatory Biomarkers
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        Title: DISCUSSION
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       Item: 
        Title: Supplementary Data
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       Item: 
        Title: Acknowledgments
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       Item: 
        Title: References
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    Title: Very-Low-Level Viremia, Inflammatory Biomarkers, and Associated Baseline Variables: Three-Year Results of the Randomized TANGO Study
    Author: Ruolan Wang
    Subject: DOI: 10.1093/ofid/ofad626; Open Forum Infectious Diseases, 11, 1, 2023-12-09.; Abstract:  Background: We compared proportions of participants with target detected, target not detected (TND), and elevated viral load (VL) and assessed baseline variables associated with week 144 inflammatory biomarker levels between dolutegravir-lamivudine (DTG/3TC) and tenofovir alafenamide–based regimens (TBRs) in the TANGO study (post hoc). Methods: TANGO is an open-label, multicenter, phase 3 study that randomized adults with VL <50 copies/mL to switch to once-daily fixed-dose DTG/3TC or continue TBR. At baseline and each study visit, the VL was measured. Elevated VL event frequencies were assessed, including “blips.” Interleukin 6, D-dimer, high-sensitivity C-reactive protein, soluble CD14, and soluble CD163 were measured at baseline and at week 144. Loge-transformed week 144 biomarker levels were compared between treatment groups using an analysis of covariance model adjusting for baseline variables. Result
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  Checksum: aa57121b
   Type: CRC32
  Checksum: 5ebb67c9fd07395c97e41e2ddb60c30c
   Type: MD5
  Checksum: 23ab71403de5863dbc33844eaeb24f009055418c
   Type: SHA-1
  Checksum: 8c4960daa8a86f4257edc61c097d8a95182edd949b1b82dcf3fd819b72fb7fcb
   Type: SHA-256