fa9bcec3137e531d5497540d751ee0f7 302164.pdf 18b36c35858f10a7008a4e384c06f6c699329cae 302164.pdf d320ed408a7eefda604cc37fac395a6cae16298f9796a1a2ad41663e2ba4b138 302164.pdf Title: Evolving AIDS- and non-AIDS Mortality and Predictors in the PISCIS Cohort of People Living With HIV in Catalonia and the Balearic Islands (Spain), 1998–2020 Subject: DOI: 10.1093/ofid/ofae132; Open Forum Infectious Diseases, 11, 4, 2024-03-08.; Abstract: Background: Effective antiretroviral therapy (ART) has substantially reduced acquired immunodeficiency syndrome (AIDS)-related deaths, shifting the focus to non-AIDS conditions in people living with human immunodeficiency virus (HIV) (PLWH). We examined mortality trends and predictors of AIDS- and non-AIDS mortality in the Population HIV Cohort from Catalonia and Balearic Islands (PISCIS) cohort of PLWH from 1998 to 2020. Methods: We used a modified Coding Causes of Death in HIV protocol, which has been widely adopted by various HIV cohorts to classify mortality causes. We applied standardized mortality rates (SMR) to compare with the general population and used competing risks models to determine AIDS-related and non-AIDS-related mortality predictors. Results: Among 30 394 PLWH (81.5% male, median age at death 47.3), crude mortality was 14.2 per 1000 person-years. All-cause standardized mortality rates d Keywords: AIDS; antiretroviral therapy; HIV; mortality; non-AIDS cancers Author: Daniel K. 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Nomah Subject: DOI: 10.1093/ofid/ofae132; Open Forum Infectious Diseases, 11, 4, 2024-03-08.; Abstract: Background: Effective antiretroviral therapy (ART) has substantially reduced acquired immunodeficiency syndrome (AIDS)-related deaths, shifting the focus to non-AIDS conditions in people living with human immunodeficiency virus (HIV) (PLWH). We examined mortality trends and predictors of AIDS- and non-AIDS mortality in the Population HIV Cohort from Catalonia and Balearic Islands (PISCIS) cohort of PLWH from 1998 to 2020. Methods: We used a modified Coding Causes of Death in HIV protocol, which has been widely adopted by various HIV cohorts to classify mortality causes. We applied standardized mortality rates (SMR) to compare with the general population and used competing risks models to determine AIDS-related and non-AIDS-related mortality predictors. Results: Among 30 394 PLWH (81.5% male, median age at death 47.3), crude mortality was 14.2 per 1000 person-years. 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antiretroviral therapy; HIV; mortality; non-AIDS cancers PDFlib+PDI 9.0.7p3 (C++/Win64); modified using iTextSharp 4.1.6 by 1T3XT application/pdf 10.1093/ofid/ofae132 en Oxford University Press Evolving AIDS- and non-AIDS Mortality and Predictors in the PISCIS Cohort of People Living With HIV in Catalonia and the Balearic Islands (Spain), 1998–2020 Daniel K. Nomah Suju Jamarkattel Andreu Bruguera Sergio Moreno-Fornés Yesika Díaz Lucía Alonso Jordi Aceitón Josep M. Llibre Pere Domingo Maria Saumoy Francesc Homar Francisco Fanjul Jordi Navarro Lorena de la Mora Hernando Knobel Amat Orti Raquel Martin-Iguacel José M. Miró Jordi Casabona Juliana Reyes-Urueña the PISCIS Cohort Study Group DOI: 10.1093/ofid/ofae132; Open Forum Infectious Diseases, 11, 4, 2024-03-08.; Abstract: Background: Effective antiretroviral therapy (ART) has substantially reduced acquired immunodeficiency syndrome (AIDS)-related deaths, shifting the focus to non-AIDS conditions in people living with human immunodeficiency virus (HIV) (PLWH). We examined mortality trends and predictors of AIDS- and non-AIDS mortality in the Population HIV Cohort from Catalonia and Balearic Islands (PISCIS) cohort of PLWH from 1998 to 2020. Methods: We used a modified Coding Causes of Death in HIV protocol, which has been widely adopted by various HIV cohorts to classify mortality causes. We applied standardized mortality rates (SMR) to compare with the general population and used competing risks models to determine AIDS-related and non-AIDS-related mortality predictors. Results: Among 30 394 PLWH (81.5% male, median age at death 47.3), crude mortality was 14.2 per 1000 person-years. All-cause standardized mortality rates d © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. AIDS antiretroviral therapy HIV mortality non-AIDS cancers Journal Open Forum Infectious Diseases © The Author(s) 2024. 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