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Title:           Multiomics plasma effects of switching from triple antiretroviral regimens to dolutegravir plus lamivudine
Subject:         DOI: 10.1093/jac/dkae083; Journal of Antimicrobial Chemotherapy, 79, 5, 2024-03-28.; Abstract:  Introduction: The DOLAM trial revealed that switching from triple antiretroviral therapy (three-drug regimen; 3DR) to dolutegravir plus lamivudine (two-drug regimen; 2DR) was virologically non-inferior to continuing 3DR after 48 weeks of follow-up. Weight increased with 2DR relative to 3DR but it did not impact on metabolic parameters. Methods: Multiomics plasma profile was performed to gain further insight into whether this therapy switch might affect specific biological pathways. DOLAM (EudraCT 201500027435) is a Phase 4, randomized, open-label, non-inferiority trial in which virologically suppressed persons with HIV treated with 3DR were assigned (1:1) to switch to 2DR or to continue 3DR for 48 weeks. Untargeted proteomics, metabolomics and lipidomics analyses were performed at baseline and at 48 weeks. Univariate and multivariate analyses were performed to identify changes in key molec
Keywords:        
Author:          Elisa de Lazzari
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     Item: 
      Title: Multiomics plasma effects of switching from triple antiretroviralregimens to dolutegravir plus lamivudine
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       Item: 
        Title: Introduction
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       Item: 
        Title: Methods
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         Item: 
          Title: Study design
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          Title: Study participants and data collection
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          Title: Determination of the proteomic profile
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          Title: Determination of the metabolomic profile (analytical method)
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          Title: Statistical analysis
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        Title: Ethics
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       Item: 
        Title: Results
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         Item: 
          Title: Patient characteristics
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         Item: 
          Title: Switching from 3DR to 2DR is associated with the p53 signalling pathway
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         Item: 
          Title: Switching from 3DR to 2DR is associated with increased alanine and TG 48:0
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        Title: Data availability
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        Title: Supplementary data
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    Title: Multiomics plasma effects of switching from triple antiretroviral regimens to dolutegravir plus lamivudine
    Author: Elisa de Lazzari
    Subject: DOI: 10.1093/jac/dkae083; Journal of Antimicrobial Chemotherapy, 79, 5, 2024-03-28.; Abstract:  Introduction: The DOLAM trial revealed that switching from triple antiretroviral therapy (three-drug regimen; 3DR) to dolutegravir plus lamivudine (two-drug regimen; 2DR) was virologically non-inferior to continuing 3DR after 48 weeks of follow-up. Weight increased with 2DR relative to 3DR but it did not impact on metabolic parameters. Methods: Multiomics plasma profile was performed to gain further insight into whether this therapy switch might affect specific biological pathways. DOLAM (EudraCT 201500027435) is a Phase 4, randomized, open-label, non-inferiority trial in which virologically suppressed persons with HIV treated with 3DR were assigned (1:1) to switch to 2DR or to continue 3DR for 48 weeks. Untargeted proteomics, metabolomics and lipidomics analyses were performed at baseline and at 48 weeks. Univariate and multivariate analyses were performed to identify changes in key molec
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  Checksum: 7402f769
   Type: CRC32
  Checksum: 2ce3a02efd517aedf010ea5487caf78c
   Type: MD5
  Checksum: 7eca7ebea5c0392a4302c46a42999c4f1addc75d
   Type: SHA-1
  Checksum: b8300b0d9aebcc7cc154d0cd8e0695ed96d1132527b6951bd72d0e14c38a458f
   Type: SHA-256