8f9bd7572caaf31792d2355585b17a7f jcm-13-02835.pdf d7d98739d07d9f45417e0db280797f06c9145b3c jcm-13-02835.pdf 99d13b5f933ff4f8ca6ebe2b2db47648046b05f6b805e2864e76be90e6af5700 jcm-13-02835.pdf Title: Quantitative Microvascular Change Analysis Using a Semi-Automated Software in Macula-off Rhegmatogenous Retinal Detachment Assessed by Swept-Source Optical Coherence Tomography Angiography Subject: Objective: To analyze the performance of custom semi-automated software for quantitative analysis of retinal capillaries in eyes with macula-off rhegmatogenous retinal detachment (RRD) and the role of these microvascular measures as potential biomarkers of postoperative visual outcomes. Methods: A prospective, observational, and single-center study was conducted on consecutive patients who underwent 25G pars-plana vitrectomy for primary uncomplicated macula-off RRD. Optical coherence tomography angiography (OCTA) was performed in the fellow and RRD eyes before surgery and in months 1, 3, and 6 after surgery. The preoperative values of the fellow eyes were used as surrogates of macula-off ones. The primary endpoints were the mean vessel diameter index (VDI); vessel area density (VAD); and vessel skeleton density (VSD) at month 6. Results: Forty-four eyes (44 patients) were included in the study. Considering the fellow eyes as a surrogate of preoperative values of macula-off eyes, VDI in superficial (SCP) and deep (DCP) capillary plexuses was significantly reduced at month 6 (p = 0.0087 and p = 0.0402, respectively); whereas VSD in SCP increased significantly from preoperative values (p = 0.0278). OCTA built-in software parameters were significantly reduced from month 1 to month 6 in both SCP and DCP (p values ranged between 0.0235 and <0.0001). At month 6, 25 (56.8%) eyes achieved a best-corrected visual acuity BCVA 0.3 (LogMAR). The greater the preoperative BCVA, the greater the probability of achieving good visual outcomes (Odds ratio: 11.06; p = 0.0037). However, none of the OCTA parameters were associated with the probability of achieving a BCVA improvement 0.3. Conclusions: Quantitative evaluation of capillary density and morphology through OCTA and semi-automated software represents a valuable tool for clinical assessment and managing the disease comprehensively. Keywords: rhegmatogenous retinal detachment; microvascular changes; OCTA; macula off Author: Pablo Díaz-Aljaro, Javier Zarranz-Ventura, Laura Broc-Iturralde, Nevena Romanic-Bubalo, Ignacio Díaz-Aljaro, Zhongdi Chu, Ruikang K. Wang and Xavier Valldeperas Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Sat May 11 10:46:57 2024 CEST ModDate: Sat May 11 10:50:57 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2137334 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 BHFDIE+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 ILWVJL+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 KWMQCR+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 CZMDWU+CMSY10 Type 1 Builtin yes yes yes 32 0 PNJMNO+VnURWPalladioL Type 1 Custom yes yes yes 37 0 XPUSBJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 53 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 56 0 NHCIJE+Arial,Italic TrueType WinAnsi yes yes no 89 0 NHCHIC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 92 0 NHCHJD+PalatinoLinotype CID TrueType Identity-H yes yes yes 95 0 NHCHJE+PalatinoLinotype TrueType WinAnsi yes yes no 101 0 NHCHJG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 104 0 NHCHPE+PalatinoLinotype TrueType MacRoman yes yes no 107 0 OVNEXW+EURM10 Type 1 Builtin yes yes yes 116 0 NHCJIP+YuGothic CID TrueType Identity-H yes yes yes 128 0 NHCHIC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 134 0 NHCHJD+PalatinoLinotype CID TrueType Identity-H yes yes yes 137 0 NHCHJE+PalatinoLinotype TrueType WinAnsi yes yes no 143 0 NHCHJG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 146 0 NHCHPE+PalatinoLinotype TrueType MacRoman yes yes no 149 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes yes 156 0 BHCMFK+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 169 0 BHCMKJ+TimesNewRoman CID TrueType Identity-H yes yes yes 172 0 BHCILF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 178 0 BHCILG+PalatinoLinotype CID TrueType Identity-H yes yes yes 181 0 BHCILH+PalatinoLinotype TrueType WinAnsi yes yes no 187 0 BHCILJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 190 0 BHCJDH+PalatinoLinotype TrueType MacRoman yes yes no 193 0 NHCLOE+Arial CID TrueType Identity-H yes yes yes 212 0 NHCHIC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 218 0 NHCHJD+PalatinoLinotype CID TrueType Identity-H yes yes yes 221 0 NHCHJE+PalatinoLinotype TrueType WinAnsi yes yes no 227 0 NHCHJG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 230 0 NHCHPE+PalatinoLinotype TrueType MacRoman yes yes no 233 0 NHCLOE+Arial CID TrueType Identity-H yes yes yes 255 0 NHCHIC+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 261 0 NHCHJD+PalatinoLinotype CID TrueType Identity-H yes yes yes 264 0 NHCHJE+PalatinoLinotype TrueType WinAnsi yes yes no 270 0 NHCHJG+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 273 0 NHCHPE+PalatinoLinotype TrueType MacRoman yes yes no 276 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-18 02:45:46 CEST RepresentationInformation: jcm-13-02835.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-10-17 16:57:23 CEST Size: 2137334 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 463 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Study Participants Destination: subsection.2.2 Children: Item: Title: Surgical Technique Destination: subsubsection.2.2.1 Item: Title: Optical Coherence Tomography Angiography Destination: subsubsection.2.2.2 Item: Title: Main Outcomes Destination: subsection.2.3 Item: Title: Statistical Analysis Destination: subsection.2.4 Item: Title: Results Destination: section.3 Children: Item: Title: Preoperative Demographic and Clinical Characteristics Destination: subsection.3.1 Item: Title: Semi-Automated Software Parameters Destination: subsection.3.2 Item: Title: OCTA Built-In Software Parameters Destination: subsection.3.3 Item: Title: Best Corrected Visual Acuity Destination: subsection.3.4 Item: Title: Predictive Factors for Functional Outcome Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: References Destination: appendix.A. Info: Title: Quantitative Microvascular Change Analysis Using a Semi-Automated Software in Macula-off Rhegmatogenous Retinal Detachment Assessed by Swept-Source Optical Coherence Tomography Angiography Author: Pablo Díaz-Aljaro, Javier Zarranz-Ventura, Laura Broc-Iturralde, Nevena Romanic-Bubalo, Ignacio Díaz-Aljaro, Zhongdi Chu, Ruikang K. Wang and Xavier Valldeperas Subject: Objective: To analyze the performance of custom semi-automated software for quantitative analysis of retinal capillaries in eyes with macula-off rhegmatogenous retinal detachment (RRD) and the role of these microvascular measures as potential biomarkers of postoperative visual outcomes. Methods: A prospective, observational, and single-center study was conducted on consecutive patients who underwent 25G pars-plana vitrectomy for primary uncomplicated macula-off RRD. Optical coherence tomography angiography (OCTA) was performed in the fellow and RRD eyes before surgery and in months 1, 3, and 6 after surgery. The preoperative values of the fellow eyes were used as surrogates of macula-off ones. The primary endpoints were the mean vessel diameter index (VDI); vessel area density (VAD); and vessel skeleton density (VSD) at month 6. Results: Forty-four eyes (44 patients) were included in the study. Considering the fellow eyes as a surrogate of preoperative values of macula-off eyes, VDI in superficial (SCP) and deep (DCP) capillary plexuses was significantly reduced at month 6 (p = 0.0087 and p = 0.0402, respectively); whereas VSD in SCP increased significantly from preoperative values (p = 0.0278). OCTA built-in software parameters were significantly reduced from month 1 to month 6 in both SCP and DCP (p values ranged between 0.0235 and <0.0001). At month 6, 25 (56.8%) eyes achieved a best-corrected visual acuity BCVA 0.3 (LogMAR). The greater the preoperative BCVA, the greater the probability of achieving good visual outcomes (Odds ratio: 11.06; p = 0.0037). However, none of the OCTA parameters were associated with the probability of achieving a BCVA improvement 0.3. Conclusions: Quantitative evaluation of capillary density and morphology through OCTA and semi-automated software represents a valuable tool for clinical assessment and managing the disease comprehensively. 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