cb9a2e1662cffa0a390d7aa44a35a634 toxics-12-00689.pdf 8207dafdcc3842c8ac2a7d07e28f3d4de46ad1bc toxics-12-00689.pdf f69c28f7f9310eaa37b4612e08220aca15c7175c462fdd72429e514f49867488 toxics-12-00689.pdf Title: Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population Subject: Self-reported occupational exposure was previously associated with COPD in the Spanish population. This study aimed to analyse the relationship between occupational exposure to various chemical and biological agents, COPD, emphysema, and the bronchial wall area, which was determined by lung computed tomography (CT) in 226 individuals with COPD and 300 individuals without COPD. Lifetime occupational exposures were assessed using the ALOHA(+) job exposure matrix, and CT and spirometry were also performed. COPD was associated with high exposure to vapours, gases, dust and fumes (VGDF) (OR 2.25 95% CI 1.19–4.22), biological dust (OR 3.01 95% CI 1.22–7.45), gases/fumes (OR 2.49 95% CI 1.20–5.17) and with exposure to various types of solvents. High exposure to gases/fumes, chlorinated solvents and metals (coefficient 8.65 95% CI 1.21–16.09, 11.91 95%CI 0.46- 23.36, 14.45 95% CI 4.42–24.49, respectively) and low exposure to aromatic solvents (coefficient 8.43 95% CI 1.16–15.70) were associated with a low 15th percentile of lung density indicating emphysema. We conclude that occupational exposure to several specific agents is associated with COPD and emphysema in the Spanish population. Keywords: chronic obstructive pulmonary disease; COPD; occupational exposures; job exposure matrix; JEM; computed tomography; emphysema Author: Eduardo Loeb, Jan-Paul Zock, Marc Miravitlles, Esther Rodríguez, Hans Kromhout, Roel Vermeulen, Juan José Soler-Cataluña, Joan B. Soriano, Francisco García-Río, Pilar de Lucas, Inmaculada Alfageme, Ciro Casanova, José Rodríguez González-Moro, Julio Ancochea, Borja G. Cosío and Jaume Ferrer Sancho Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Tue Sep 24 08:52:09 2024 CEST ModDate: Tue Sep 24 08:54:20 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 299126 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IOJCNK+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 YZKDCA+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 KCTXJR+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 FEEKTC+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 WASDUU+VnURWPalladioL Type 1 Custom yes yes yes 32 0 MPBHTC+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 SSJMKU+CMSY10 Type 1 Builtin yes yes yes 71 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 76 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-10-31 02:39:35 CET RepresentationInformation: toxics-12-00689.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-10-30 17:01:57 CET Size: 299126 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 285 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Design Destination: subsection.2.1 Item: Title: Study Subjects Destination: subsection.2.2 Item: Title: Procedures and Measurements Destination: subsection.2.3 Children: Item: Title: Study Variables Destination: subsubsection.2.3.1 Item: Title: Statistical Analysis Destination: subsubsection.2.3.2 Item: Title: Results Destination: section.3 Children: Item: Title: Population Destination: subsection.3.1 Item: Title: Occupational Exposures and COPD Destination: subsection.3.2 Item: Title: Relationship between COPD and Radiological Variables Destination: subsection.3.3 Item: Title: Radiological Variables According to Occupational Exposure Destination: subsection.3.4 Item: Title: Relationship between Occupational Exposure and Radiological Variables with Respiratory Symptoms Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: appendix.A. Info: Title: Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population Author: Eduardo Loeb, Jan-Paul Zock, Marc Miravitlles, Esther Rodríguez, Hans Kromhout, Roel Vermeulen, Juan José Soler-Cataluña, Joan B. Soriano, Francisco García-Río, Pilar de Lucas, Inmaculada Alfageme, Ciro Casanova, José Rodríguez González-Moro, Julio Ancochea, Borja G. Cosío and Jaume Ferrer Sancho Subject: Self-reported occupational exposure was previously associated with COPD in the Spanish population. This study aimed to analyse the relationship between occupational exposure to various chemical and biological agents, COPD, emphysema, and the bronchial wall area, which was determined by lung computed tomography (CT) in 226 individuals with COPD and 300 individuals without COPD. Lifetime occupational exposures were assessed using the ALOHA(+) job exposure matrix, and CT and spirometry were also performed. COPD was associated with high exposure to vapours, gases, dust and fumes (VGDF) (OR 2.25 95% CI 1.19 4.22), biological dust (OR 3.01 95% CI 1.22 7.45), gases/fumes (OR 2.49 95% CI 1.20 5.17) and with exposure to various types of solvents. High exposure to gases/fumes, chlorinated solvents and metals (coefficient 8.65 95% CI 1.21 16.09, 11.91 95%CI 0.46- 23.36, 14.45 95% CI 4.42 24.49, respectively) and low exposure to aromatic solvents (coefficient 8.43 95% CI 1.16 15.70) were associated with a low 15th percentile of lung density indicating emphysema. We conclude that occupational exposure to several specific agents is associated with COPD and emphysema in the Spanish population. 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