2023116851a957be911f7868e1624edd  JouCliEndMet_a2024.pdf
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Title:           Personalized Medicine in Acromegaly: The ACROFAST Study
Subject:         DOI: 10.1210/clinem/dgae444; The Journal of Clinical Endocrinology & Metabolism, 00, 0, 2024-06-29.; Abstract:  Context: Medical treatment of acromegaly is currently performed through a trial-and-error approach using first-generation somatostatin receptor ligands (fgSRLs) as first-line drugs, with an effectiveness of about 50%, and subsequent drugs are indicated through clinical judgment. Some biomarkers can predict fgSRLs response. Objective: Here we report the results of the ACROFAST study, a clinical trial in which a protocol based on predictive biomarkers of fgSRLs was evaluated. Methods: This was a prospective trial (21 university hospitals) comparing the effectiveness and time-to-control of 2 treatment protocols during 12 months: (A) a personalized protocol in which the first options were fgSRLs as monotherapy or in combination with pegvisomant, or pegvisomant as monotherapy depending on the short acute octreotide test (sAOT) results, tumor T2 magnetic resonance (MRI) signal or
Keywords:        acromegaly; medical treatment; personalized therapy; first-generation somatostatin receptor ligands; therapeutic response prediction; clinical trial
Author:          Montserrat Marques-Pamies
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  Checksum: 0ff3c80d
   Type: CRC32
  Checksum: 2023116851a957be911f7868e1624edd
   Type: MD5
  Checksum: c7b656a1ebb881b384ad2a1cb2cf9f88732d5cd1
   Type: SHA-1
  Checksum: 6e35f6fb733e04c72a3764f4beee3e0bc83aba1fb0b3a9ca35f33a83e658dc31
   Type: SHA-256