54d520e92c11d16a6a55b049e5df711f 304068.pdf 2b2b486640b8e3dfefb7a6d3ba7cf25fc00fef00 304068.pdf 1d5310c859f4d077998f1ee8556db34f63560cf31711cefcfc6778363d1822af 304068.pdf Title: Peripartum Takotsubo Cardiomyopathy: A Review and Insights from a National Registry Subject: Takotsubo syndrome (TTS) during the peripartum period is a relevant cause of morbidity in this population; its clinical course and prognosis, compared to the general TTS population, is yet to be elucidated. Our aim was to analyze the clinical features and prognosis of peripartum TTS in a nationwide prospective specifically oriented registry database and consider the published literature. Peripartum TTS patients from the prospective nationwide RETAKO registry—as well as peripartum TTS patients from the published literature—were included, and multiple comparisons between groups were performed in order to assess for statistically and clinically relevant prognostic differences between the groups. Patients with peripartum TTS exhibit a higher prevalence of secondary forms, dyspnea, atypical symptoms, and echocardiographic patterns, as well as less ST-segment elevation than the general TTS population. In the literature, patients with peripartum TTS had a higher Killip status on admission. TTS during the peripartum period has a higher prevalence of angina and dyspnea, as well as physical triggers, neither of which are related to a worse prognosis. Killip status on admission was higher in the literature for patients with TTS but with excellent mid- and long-term prognoses after the acute phase, despite mostly being secondary forms. Keywords: takotsubo syndrome; prognosis; registry; women; peripartum; pregnancy; cardiomyopathy Author: Ravi Vazirani, Emilia Blanco-Ponce, Manuel Almendro Delia, Agustín C. Martín-Garcia, Clara Fernández-Cordón, Aitor Uribarri, Oscar Vedia, Alessandro Sionis, Jorge Salamanca, Miguel Corbí-Pascual, Alberto Pérez-Castellanos, Manuel Martínez-Selles, Víctor Manuel-Becerra, Sergio Raposeiras-Roubín, David Aritza-Conty, Javier Lopez-País, Marta Guillén-Marzo, Carmen Lluch-Requerey and Iván J. Núñez-Gil Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Fri Jan 26 10:27:06 2024 CET ModDate: Fri Jan 26 10:35:29 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 698321 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DGBDNV+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 YWQWLZ+VnURWPalladioL Type 1 Custom yes yes yes 16 0 MFWGFQ+URWPalladioL-Bold Type 1 Custom yes yes yes 21 0 RQJFBY+URWPalladioL-Roma Type 1 Custom yes yes yes 27 0 AVTEZZ+URWPalladioL-Ital Type 1 Custom yes yes yes 32 0 VGVAWT+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 49 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 52 0 LGTZLE+CMSY10 Type 1 Builtin yes yes yes 72 0 CIDFont+F3 CID TrueType Identity-H yes no yes 79 0 CIDFont+F1 CID TrueType Identity-H yes no yes 87 0 CIDFont+F2 CID TrueType Identity-H yes no yes 95 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 107 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-01-13 02:36:22 CET RepresentationInformation: 304068.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-01-08 17:37:12 CET Size: 698321 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 246 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Material and Methods Destination: section.2 Children: Item: Title: Review Methods Destination: subsection.2.1 Item: Title: Registry Data and Study Definitions Destination: subsection.2.2 Item: Title: Statistical Analysis Destination: subsection.2.3 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Limitations Destination: section.5 Item: Title: Conclusions Destination: section.6 Item: Title: References Destination: appendix.A. Info: Title: Peripartum Takotsubo Cardiomyopathy: A Review and Insights from a National Registry Author: Ravi Vazirani, Emilia Blanco-Ponce, Manuel Almendro Delia, Agustín C. Martín-Garcia, Clara Fernández-Cordón, Aitor Uribarri, Oscar Vedia, Alessandro Sionis, Jorge Salamanca, Miguel Corbí-Pascual, Alberto Pérez-Castellanos, Manuel Martínez-Selles, Víctor Manuel-Becerra, Sergio Raposeiras-Roubín, David Aritza-Conty, Javier Lopez-País, Marta Guillén-Marzo, Carmen Lluch-Requerey and Iván J. Núñez-Gil Subject: Takotsubo syndrome (TTS) during the peripartum period is a relevant cause of morbidity in this population; its clinical course and prognosis, compared to the general TTS population, is yet to be elucidated. Our aim was to analyze the clinical features and prognosis of peripartum TTS in a nationwide prospective specifically oriented registry database and consider the published literature. Peripartum TTS patients from the prospective nationwide RETAKO registry as well as peripartum TTS patients from the published literature were included, and multiple comparisons between groups were performed in order to assess for statistically and clinically relevant prognostic differences between the groups. Patients with peripartum TTS exhibit a higher prevalence of secondary forms, dyspnea, atypical symptoms, and echocardiographic patterns, as well as less ST-segment elevation than the general TTS population. In the literature, patients with peripartum TTS had a higher Killip status on admission. TTS during the peripartum period has a higher prevalence of angina and dyspnea, as well as physical triggers, neither of which are related to a worse prognosis. Killip status on admission was higher in the literature for patients with TTS but with excellent mid- and long-term prognoses after the acute phase, despite mostly being secondary forms. 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