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Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Materials and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Study cohort Destination: mk:H2_1 Item: Title: 2.2 Data collection Destination: mk:H2_2 Children: Item: Title: 2.2.1 Questionnaire-based risk factors Destination: mk:H3_3 Item: Title: 2.2.2 Pedigrees and medical information Destination: mk:H3_4 Item: Title: 2.2.3 Genotyping Destination: mk:H3_5 Item: Title: 2.3 Statistical analysis Destination: mk:H2_6 Children: Item: Title: 2.3.1 Cumulative risk score calculation Destination: mk:H3_7 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 Characteristics of the study population Destination: mk:H2_8 Item: Title: 3.2 Stepwise addition of risk factors and BC risk distribution Destination: mk:H2_9 Item: Title: 3.3 Stepwise addition of risk factors and reclassification of risk category Destination: mk:H2_10 Item: Title: 3.4 BC risk stratification using PRS313 versus PRS311 Destination: mk:H2_11 Item: Title: 3.5 Risk stratification separated by variant status and distant relatives Destination: mk:H2_12 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: Ethics approval Destination: mk:H1_5 Item: Title: Funding statement Destination: mk:H1_6 Item: Title: Data availability Destination: mk:H1_7 Item: Title: Consent to participate Destination: mk:H1_8 Item: Title: CRediT authorship contribution statement Destination: mk:H1_9 Item: Title: Declaration of competing interest Destination: mk:HH1_2 Item: Title: Acknowledgements Destination: mk:HH1_3 Item: Title: Appendix A Supplementary data Destination: mk:H1_10 Item: Title: References Destination: mk:HH2_1 Info: Title: The benefit of adding polygenic risk scores, lifestyle factors, and breast density to family history and genetic status for breast cancer risk and surveillance classification of unaffected women from germline CHEK2 c.1100delC families Author: Maartje A.C. Schreurs Subject: The Breast, 73 (2024) 103611. doi:10.1016/j.breast.2023.103611 Keywords: CHEK2 c.1100delC,Breast cancer,Risk prediction Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Feb 23 09:20:39 CET 2024 ModDate: Fri Feb 23 09:22:54 CET 2024 ID: 0x24517045e7952ef346ced20595a16237, 0x25b213e23796c2fc82fb91cd49c7fec3 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: IKQZGS+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: QIQCIK+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: DRCQFG+CharisSIL-BoldItalic Encoding: Identity-H ToUnicode: true Font: BaseFont: PKYUYH+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: ERNRUV+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: ERNRUV+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: IFDGUN+TeX_CM_Bold_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 255 FontDescriptor: FontName: IFDGUN+TeX_CM_Bold_Maths_Symbols Flags: Symbolic, ForceBold FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NJNTQE+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: NJNTQE+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: VYYUFA+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: VYYUFA+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: VVCCGG+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: VVCCGG+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: ALYIIH+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: ALYIIH+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: IKQZGS+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: IKQZGS+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: QIQCIK+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: QIQCIK+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Font: BaseFont: DRCQFG+CharisSIL-BoldItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: DRCQFG+CharisSIL-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -741, -533, 1795, 1320 FontFile2: true Font: BaseFont: PKYUYH+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: PKYUYH+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true XMP: application/pdf 10.1016/j.breast.2023.103611 Elsevier Ltd The Breast, 73 (2024) 103611. doi:10.1016/j.breast.2023.103611 CHEK2 c.1100delC Breast cancer Risk prediction The benefit of adding polygenic risk scores, lifestyle factors, and breast density to family history and genetic status for breast cancer risk and surveillance classification of unaffected women from germline CHEK2 c.1100delC families Maartje A.C. Schreurs Teresa Ramón y Cajal Muriel A. Adank J. Margriet Collée Antoinette Hollestelle Jeroen van Rooij Marjanka K. Schmidt Maartje J. Hooning journal The Breast © 2023 The Authors. Published by Elsevier Ltd. 0960-9776 73 1 February 2024 2024-02-01 103611 103611 10.1016/j.breast.2023.103611 https://doi.org/10.1016/j.breast.2023.103611 2010-04-23 true 10.1016/j.breast.2023.103611 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by/4.0/ VoR 10.1016/j.breast.2023.103611 noindex 2010-04-23 true 23rd February 2024 sciencedirect.com elsevier.com Elsevier 2024-02-23T08:22:54 2024-02-23T08:20:39 2024-02-23T08:22:54 True 23rd February 2024 Acrobat Distiller 8.1.0 (Windows) CHEK2 c.1100delC,Breast cancer,Risk prediction uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 142, 537, 257, 547 Flags: Print Destination: 600 Annotation: Subtype: Link Rect: 257, 537, 348, 547 Flags: Print Destination: 600 Annotation: Subtype: Link Rect: 348, 537, 444, 547 Flags: Print Destination: 600 Annotation: Subtype: Link Rect: 444, 537, 452, 547 Flags: Print Destination: 600 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