ddd7ce6dc57eaf265bf97c989bc285dc 304082.pdf f81f74d7a60cfab7f258594091c319286d424028 304082.pdf 4a8724cefecb00ed9eac4dccdcdfd72900e01ffdc28e964df1f7ff3bdec1cb13 304082.pdf Title: Effectiveness of Influenza Vaccination and Early Antiviral Treatment in Reducing Pneumonia Risk in Severe Influenza Cases Subject: Introduction: Influenza vaccination may be effective in preventing influenza infection and may reduce the risk of influenza-associated pneumonia. The study aim was to evaluate the effect of influenza vaccination in preventing pneumonia when it failed to prevent influenza hospitalization. Methods: This was a case–control study comparing hospitalized cases of influenza with and without pneumonia in patients aged 18 years in 16 hospitals in Catalonia over 10 influenza seasons (2010–11 to 2019–20). Data on sociodemographic, virological characteristics, comorbidities, vaccination history, and antiviral treatment were collected and analysed. The crude odds ratio (OR) and adjusted OR (aOR) with the corresponding 95% confidence interval (CI) values were calculated. Results: In total, 5080 patients hospitalized for severe influenza were included, 63.5% (3224/5080) of whom had pneumonia—mostly men (56.8%; 1830/3224) and mostly in the 75 age group (39.3%; 1267/3224)—and of whom 14.0% died (451/3224). Virus A and virus B accounted for 78.1% (2518/3224) and 21.9% (705/3224) of influenza types, respectively. Starting antiviral treatment 48 h after symptom onset (aOR = 0.69; 95%CI: 0.53–0.90) and a history of seasonal influenza vaccination (aOR = 0.85; 95%CI: 0.72–0.98) were protective factors in developing pneumonia. Conclusions: Adherence to seasonal influenza vaccination and starting antiviral treatment within 48 h of symptom onset can reduce pneumonia risk in severe influenza cases. Keywords: influenza; vaccination; pneumonia; antiviral treatment Author: Pere Godoy, Núria Soldevila, Ana Martínez, Sofia Godoy, Mireia Jané, Nuria Torner, Lesly Acosta, Cristina Rius, Àngela Domínguez and The Surveillance of Hospitalized Cases of Severe Influenza in Catalonia Working Group Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Thu Feb 8 09:34:06 2024 CET ModDate: Thu Feb 8 09:37:39 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 255282 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MLBXOW+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 XMESMT+VnURWPalladioL Type 1 Custom yes yes yes 16 0 REVMXW+URWPalladioL-Bold Type 1 Custom yes yes yes 21 0 LXNEIM+URWPalladioL-Roma Type 1 Custom yes yes yes 27 0 AWKAZZ+URWPalladioL-Ital Type 1 Custom yes yes yes 32 0 WIYEYL+CMSY10 Type 1 Builtin yes yes yes 37 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 76 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-01-13 02:35:54 CET RepresentationInformation: 304082.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-01-09 17:15:15 CET Size: 255282 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 205 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Methods Destination: section.2 Children: Item: Title: Laboratory Data Destination: subsection.2.1 Item: Title: Statistical Analysis Destination: subsection.2.2 Item: Title: Ethics Statement Destination: subsection.2.3 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: appendix.A. Info: Title: Effectiveness of Influenza Vaccination and Early Antiviral Treatment in Reducing Pneumonia Risk in Severe Influenza Cases Author: Pere Godoy, Núria Soldevila, Ana Martínez, Sofia Godoy, Mireia Jané, Nuria Torner, Lesly Acosta, Cristina Rius, Àngela Domínguez and The Surveillance of Hospitalized Cases of Severe Influenza in Catalonia Working Group Subject: Introduction: Influenza vaccination may be effective in preventing influenza infection and may reduce the risk of influenza-associated pneumonia. The study aim was to evaluate the effect of influenza vaccination in preventing pneumonia when it failed to prevent influenza hospitalization. Methods: This was a case control study comparing hospitalized cases of influenza with and without pneumonia in patients aged 18 years in 16 hospitals in Catalonia over 10 influenza seasons (2010 11 to 2019 20). Data on sociodemographic, virological characteristics, comorbidities, vaccination history, and antiviral treatment were collected and analysed. The crude odds ratio (OR) and adjusted OR (aOR) with the corresponding 95% confidence interval (CI) values were calculated. Results: In total, 5080 patients hospitalized for severe influenza were included, 63.5% (3224/5080) of whom had pneumonia mostly men (56.8%; 1830/3224) and mostly in the 75 age group (39.3%; 1267/3224) and of whom 14.0% died (451/3224). Virus A and virus B accounted for 78.1% (2518/3224) and 21.9% (705/3224) of influenza types, respectively. Starting antiviral treatment 48 h after symptom onset (aOR = 0.69; 95%CI: 0.53 0.90) and a history of seasonal influenza vaccination (aOR = 0.85; 95%CI: 0.72 0.98) were protective factors in developing pneumonia. Conclusions: Adherence to seasonal influenza vaccination and starting antiviral treatment within 48 h of symptom onset can reduce pneumonia risk in severe influenza cases. 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