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Title:           Overexpression of the transcriptional activators Mxr1 and Mit1 enhances lactic acid production on methanol in Komagataella phaffii
Subject:         Metabolic Engineering, 85 (2024) 133-144. doi:10.1016/j.ymben.2024.07.013
Keywords:        Lactic acid,Komagataella phaffii,Transcriptional regulation,Methanol,Synthetic biology,Circular biotechnology
Author:          Simone Bachleitner
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      Title: Overexpression of the transcriptional activators Mxr1 and Mit1 enhances lactic acid production on methanol in Komagataella  ...
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        Title: 1 Introduction
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        Title: 2 Materials and methods
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        Title: 3 Results
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         Item: 
          Title: 3.1 K. phaffii consumes lactic acid when methanol is used as a carbon source
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          Title: 3.2 Bioreactor cultivation of ldhL cyb2Δ results in low titers and high biomass formation on methanol
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          Title: 3.3 The presence of lactic acid represses MeOH-utilizing genes
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          Title: 3.4 Overexpression of transcription factors leads to higher lactic acid productivity
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          Title: 3.5 Upscaling of transcriptional activator strains resulted in higher lactic acid concentrations in bioreactor cultivations
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          Title: 3.6 Elevated MeOH levels enhance lactic acid production in bioreactor cultures of transcriptionally overexpressed strains
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        Title: 4 Discussion
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        Title: Funding
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        Title: Declaration of competing interest
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        Title: Appendix A Supplementary data
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    Author: Simone Bachleitner
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    Keywords: Lactic acid,Komagataella phaffii,Transcriptional regulation,Methanol,Synthetic biology,Circular biotechnology
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