185e9b94ddd3c4e2d968c59cbd9802c9 304841.pdf d64519a3b3b4e3ff42e401ff791eae53967f0a73 304841.pdf 64507722bf7fe6f4eb14e5341784927bcbf4c21a0f84bf9535929f2f4664880f 304841.pdf Title: Maintenance with 5-FU/LV-aflibercept after induction with FOLFIRI-aflibercept versus FOLFIRI-aflibercept until progression as second-line treatment in older adults with metastatic colorectal cancer: the AFEMA phase II randomized trial Subject: ESMO Open, 9 (2024) 103986. doi:10.1016/j.esmoop.2024.103986 Author: P. García-Alfonso Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Nov 22 18:07:38 2024 CET ModDate: Fri Nov 22 18:09:25 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 612.283 x 790.866 pts Page rot: 0 File size: 453396 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LMIAEF+AdvPS480274 Type 1C WinAnsi yes yes no 780 0 LMIAFG+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 783 0 LMHPMN+AdvTT2ffda40f.B Type 1C WinAnsi yes yes no 748 0 LMHPNO+AdvTT2ffda40f.B+fb Type 1C Custom yes yes yes 753 0 LMHPNP+AdvP4C4E74 Type 1C Custom yes yes yes 741 0 LMHPOA+AdvTT7b515deb Type 1C WinAnsi yes yes no 744 0 LMHPOB+AdvTT7b515deb+20 Type 1C WinAnsi yes yes no 746 0 LMHPOC+AdvTTe692faf0 Type 1C WinAnsi yes yes no 769 0 LMHPOD+AdvTT7b515deb+fb Type 1C Custom yes yes yes 762 0 LMHPPD+AdvPS4721B4 Type 1C WinAnsi yes yes no 764 0 LMHPPE+AdvTT06f3545d.I Type 1C WinAnsi yes yes no 766 0 LMHPPF+AdvTT47f7fe79.I Type 1C WinAnsi yes yes no 773 0 LMIAEE+AdvOT07517017 Type 1C WinAnsi yes yes no 778 0 LMIAGH+AdvTT26e64a0d.BI Type 1C WinAnsi yes yes no 437 0 LMIAHH+AdvPS3F4C13 Type 1C WinAnsi yes yes no 444 0 LMIAHI+AdvP4C4E51 Type 1C WinAnsi yes yes no 442 0 LMIAHJ+AdvOT46dcae81 Type 1C WinAnsi yes yes no 448 0 LMIAIK+AdvPS44A44B Type 1C WinAnsi yes yes no 454 0 LMIAJK+Arial-BoldMT Type 1C Custom yes yes yes 452 0 LMIAKL+ArialMT Type 1C WinAnsi yes yes no 463 0 LMIAKM+Arial-BoldItalicMT Type 1C WinAnsi yes yes no 466 0 Arial-ItalicMT Type 1C WinAnsi yes no no 469 0 LMIAMN+AdvTT26e64a0d.BI+fb Type 1C Custom yes yes yes 478 0 LMIBBM+AdvPS3FDD77 Type 1C WinAnsi yes yes no 479 0 LMIBBN+AdvTTad02f5c0 Type 1C WinAnsi yes yes no 491 0 LMIBBO+AdvTTad02f5c0+fb Type 1C Custom yes yes yes 480 0 LMIBCP+AdvTT181ea94d.I Type 1C WinAnsi yes yes no 481 0 LMIBJN+AdvP4C4E59 Type 1C Custom yes yes no 500 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2024-12-19 02:51:31 CET RepresentationInformation: 304841.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2024-12-18 15:20:14 CET Size: 453396 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 424074 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 861 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Maintenance with 5-FU/LV-aflibercept after induction with FOLFIRI-aflibercept versus FOLFIRI-aflibercept until progression ... Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Material and methods Destination: flink2 Children: Item: Title: Study design and patient eligibility Destination: slink1 Item: Title: Treatment Destination: slink2 Item: Title: Outcomes and statistical analysis Destination: slink3 Item: Title: Results Destination: flink3 Children: Item: Title: Efficacy Destination: slink4 Children: Item: Title: Primary endpoint Destination: thirlink1 Item: Title: Secondary endpoints Destination: thirlink2 Item: Title: Factors influencing OS and PFS Destination: thirlink3 Item: Title: Changes in VES-13 score during treatment Destination: thirlink4 Item: Title: Safety Destination: slink5 Item: Title: Discussion Destination: flink4 Item: Title: Conclusions Destination: flink5 Item: Title: Acknowledgements Destination: acklink1 Item: Title: Funding Destination: flink6 Item: Title: Disclosure Destination: flink7 Item: Title: Data sharing Destination: flink8 Item: Title: References Destination: blink2 Info: Title: Maintenance with 5-FU/LV-aflibercept after induction with FOLFIRI-aflibercept versus FOLFIRI-aflibercept until progression as second-line treatment in older adults with metastatic colorectal cancer: the AFEMA phase II randomized trial Author: P. García-Alfonso Subject: ESMO Open, 9 (2024) 103986. doi:10.1016/j.esmoop.2024.103986 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Nov 22 18:37:38 CET 2024 ModDate: Fri Nov 22 18:39:25 CET 2024 ID: 0x6c49c96e3134bb90d03de26a77e01799, 0x887c67a94d4fe0439eae3bf279619f4e Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: LMIAHJ+AdvOT46dcae81 FontSubset: true FirstChar: 45 LastChar: 237 FontDescriptor: FontName: LMIAHJ+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMHPOC+AdvTTe692faf0 FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: LMHPOC+AdvTTe692faf0 Flags: Serif, Nonsymbolic FontBBox: -72, -250, 916, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMIAJK+Arial-BoldMT FontSubset: true FirstChar: 2 LastChar: 122 FontDescriptor: FontName: LMIAJK+Arial-BoldMT Flags: Symbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMHPPF+AdvTT47f7fe79.I FontSubset: true FirstChar: 58 LastChar: 116 FontDescriptor: FontName: LMHPPF+AdvTT47f7fe79.I Flags: Nonsymbolic FontBBox: -156, -250, 1000, 979 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMIAIK+AdvPS44A44B FontSubset: true FirstChar: 101 LastChar: 101 FontDescriptor: FontName: LMIAIK+AdvPS44A44B Flags: Nonsymbolic FontBBox: 0, -197, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMIAEE+AdvOT07517017 FontSubset: true FirstChar: 46 LastChar: 117 FontDescriptor: FontName: LMIAEE+AdvOT07517017 Flags: Nonsymbolic FontBBox: -41, -250, 812, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMIAEF+AdvPS480274 FontSubset: true FirstChar: 45 LastChar: 45 FontDescriptor: FontName: LMIAEF+AdvPS480274 Flags: Nonsymbolic FontBBox: 0, -208, 1354, 791 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMIAFG+AdvOT3b30f6db.B FontSubset: true FirstChar: 49 LastChar: 57 FontDescriptor: FontName: LMIAFG+AdvOT3b30f6db.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMIAKL+ArialMT FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: LMIAKL+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMIAKM+Arial-BoldItalicMT FontSubset: true FirstChar: 32 LastChar: 110 FontDescriptor: FontName: LMIAKM+Arial-BoldItalicMT Flags: Nonsymbolic, Italic FontBBox: -560, -376, 1390, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Arial-ItalicMT FirstChar: 0 LastChar: 255 FontDescriptor: FontName: Arial-ItalicMT Flags: Nonsymbolic, Italic FontBBox: -517, -325, 1359, 998 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMIAMN+AdvTT26e64a0d.BI+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LMIAMN+AdvTT26e64a0d.BI+fb Flags: Symbolic FontBBox: -93, -187, 854, 677 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMIBBM+AdvPS3FDD77 FontSubset: true FirstChar: 91 LastChar: 91 FontDescriptor: FontName: LMIBBM+AdvPS3FDD77 Flags: Nonsymbolic FontBBox: 0, -208, 1145, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMIBBO+AdvTTad02f5c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LMIBBO+AdvTTad02f5c0+fb Flags: Symbolic FontBBox: 19, 0, 718, 677 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMIBCP+AdvTT181ea94d.I FontSubset: true FirstChar: 65 LastChar: 110 FontDescriptor: FontName: LMIBCP+AdvTT181ea94d.I Flags: Nonsymbolic FontBBox: -104, -187, 916, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMHPNP+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 254 FontDescriptor: FontName: LMHPNP+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMHPOA+AdvTT7b515deb FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: LMHPOA+AdvTT7b515deb Flags: Serif, Nonsymbolic FontBBox: -93, -187, 854, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMHPOB+AdvTT7b515deb+20 FontSubset: true FirstChar: 145 LastChar: 146 FontDescriptor: FontName: LMHPOB+AdvTT7b515deb+20 Flags: Nonsymbolic FontBBox: -83, -187, 1000, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMIBBN+AdvTTad02f5c0 FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: LMIBBN+AdvTTad02f5c0 Flags: Serif, Nonsymbolic FontBBox: -93, -187, 843, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMHPMN+AdvTT2ffda40f.B FontSubset: true FirstChar: 37 LastChar: 243 FontDescriptor: FontName: LMHPMN+AdvTT2ffda40f.B Flags: Serif, Nonsymbolic FontBBox: -83, -187, 875, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMHPNO+AdvTT2ffda40f.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LMHPNO+AdvTT2ffda40f.B+fb Flags: Symbolic FontBBox: 0, -187, 781, 677 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMIBJN+AdvP4C4E59 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LMIBJN+AdvP4C4E59 Flags: Symbolic FontBBox: -31, -250, 1000, 750 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: LMIAGH+AdvTT26e64a0d.BI FontSubset: true FirstChar: 69 LastChar: 121 FontDescriptor: FontName: LMIAGH+AdvTT26e64a0d.BI Flags: Serif, Nonsymbolic FontBBox: -93, -187, 958, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMHPOD+AdvTT7b515deb+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LMHPOD+AdvTT7b515deb+fb Flags: Symbolic FontBBox: 0, -187, 739, 677 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LMIAHI+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: LMIAHI+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMHPPD+AdvPS4721B4 FontSubset: true FirstChar: 97 LastChar: 98 FontDescriptor: FontName: LMHPPD+AdvPS4721B4 Flags: Nonsymbolic FontBBox: 0, -208, 843, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMIAHH+AdvPS3F4C13 FontSubset: true FirstChar: 97 LastChar: 97 FontDescriptor: FontName: LMIAHH+AdvPS3F4C13 Flags: Nonsymbolic FontBBox: 0, -291, 875, 697 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LMHPPE+AdvTT06f3545d.I FontSubset: true FirstChar: 40 LastChar: 118 FontDescriptor: FontName: LMHPPE+AdvTT06f3545d.I Flags: Nonsymbolic FontBBox: -104, -187, 937, 843 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.esmoop.2024.103986 Maintenance with 5-FU/LV-aflibercept after induction with FOLFIRI-aflibercept versus FOLFIRI-aflibercept until progression as second-line treatment in older adults with metastatic colorectal cancer: the AFEMA phase II randomized trial P. García-Alfonso E. Elez J. Soto-Alsar D. Páez A. Fernández-Montes B. Graña A. Salud A. Yubero M.A. Gómez-España I. Macías G. Quintero C. López-López T. Fernández-Rodríguez C. Grávalos E. González-Flores M. Guix B. García Paredes J.J. Reina J.R. Rodríguez Mowbray J. Sastre E. Aranda Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD) metastatic colorectal cancer aflibercept FOLFIRI 5-FU maintenance treatment ESMO Open, 9 (2024) 103986. doi:10.1016/j.esmoop.2024.103986 The Authors journal ESMO Open © 2024 The Authors. Published by Elsevier Ltd on behalf of European Society for Medical Oncology. 2059-7029 9 12 December 2024 103986 103986 10.1016/j.esmoop.2024.103986 https://doi.org/10.1016/j.esmoop.2024.103986 2010-04-23 true 10.1016/j.esmoop.2024.103986 elsevier.com sciencedirect.com VoR 7.0.1 10.1016/j.esmoop.2024.103986 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2024-11-22T22:37:38+05:30 2024-11-22T22:39:25+05:30 2024-11-22T22:39:25+05:30 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json Acrobat Distiller 8.1.0 (Windows) uuid:d23321ef-0e1e-40a7-aef1-1d77c39d04c9 uuid:2b43b139-3e78-429e-8366-dd001ad2ab01 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 122, 590, 122, 592 Annotation: Subtype: Link Rect: 122, 591, 125, 599 Destination: 654 Annotation: Subtype: Link Rect: 125, 591, 129, 599 Destination: 654 Annotation: Subtype: Link Rect: 129, 591, 133, 597 Destination: 654 Annotation: Subtype: Link Rect: 163, 590, 163, 592 Annotation: Subtype: Link Rect: 163, 591, 167, 599 Destination: 654 Annotation: Subtype: Link Rect: 222, 590, 222, 592 Annotation: Subtype: Link Rect: 222, 591, 226, 599 Destination: 654 Annotation: Subtype: Link Rect: 260, 590, 260, 592 Annotation: Subtype: Link Rect: 260, 591, 264, 599 Destination: 654 Annotation: Subtype: Link Rect: 354, 590, 354, 592 Annotation: Subtype: Link Rect: 354, 591, 358, 598 Destination: 654 Annotation: Subtype: Link Rect: 398, 590, 398, 592 Annotation: Subtype: Link Rect: 398, 591, 401, 598 Destination: 654 Annotation: Subtype: Link Rect: 440, 590, 440, 592 Annotation: Subtype: Link Rect: 440, 591, 443, 599 Destination: 654 Annotation: Subtype: Link Rect: 487, 590, 487, 592 Annotation: Subtype: Link Rect: 487, 591, 491, 598 Destination: 654 Annotation: Subtype: Link Rect: 137, 579, 137, 580 Annotation: Subtype: Link Rect: 137, 579, 141, 587 Destination: 654 Annotation: Subtype: Link Rect: 182, 579, 182, 580 Annotation: Subtype: Link Rect: 182, 579, 186, 587 Destination: 654 Annotation: Subtype: Link Rect: 238, 579, 238, 580 Annotation: Subtype: Link Rect: 238, 579, 245, 587 Destination: 654 Annotation: Subtype: Link Rect: 309, 579, 309, 580 Annotation: Subtype: Link Rect: 309, 579, 316, 587 Destination: 654 Annotation: Subtype: Link Rect: 413, 579, 413, 580 Annotation: Subtype: Link Rect: 413, 579, 420, 587 Destination: 654 Annotation: Subtype: Link Rect: 470, 579, 470, 580 Annotation: Subtype: Link Rect: 470, 579, 477, 587 Destination: 654 Annotation: Subtype: Link Rect: 126, 567, 126, 569 Annotation: Subtype: Link Rect: 126, 568, 133, 576 Destination: 654 Annotation: Subtype: Link Rect: 169, 567, 169, 569 Annotation: Subtype: Link Rect: 169, 568, 176, 576 Destination: 654 Annotation: Subtype: Link Rect: 250, 567, 250, 569 Annotation: Subtype: Link Rect: 250, 568, 257, 576 Destination: 654 Annotation: Subtype: Link Rect: 300, 567, 300, 569 Annotation: Subtype: Link Rect: 300, 568, 307, 576 Destination: 654 Annotation: Subtype: Link Rect: 410, 567, 410, 569 Annotation: Subtype: Link Rect: 410, 568, 417, 576 Destination: 654 Annotation: Subtype: Link Rect: 454, 567, 454, 569 Annotation: Subtype: Link Rect: 454, 568, 461, 576 Destination: 654 Annotation: Subtype: Link Rect: 461, 568, 464, 576 Destination: 654 Annotation: Subtype: Link Rect: 514, 567, 514, 569 Annotation: Subtype: Link Rect: 514, 568, 518, 576 Destination: 654 Annotation: Subtype: Link Rect: 86, 69, 167, 76 Annotation: Subtype: Link Rect: 80, 37, 238, 43 Annotation: Subtype: Link Rect: 55, 392, 71, 414 Annotation: Subtype: Link Rect: 426, 15, 552, 24 Annotation: Subtype: Link Rect: 426, 15, 557, 24 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 191, 694, 195, 704 Destination: 199 Annotation: Subtype: Link Rect: 196, 694, 200, 704 Destination: 199 Annotation: Subtype: Link Rect: 189, 670, 193, 680 Destination: 199 Annotation: Subtype: Link Rect: 117, 634, 120, 644 Destination: 199 Annotation: Subtype: Link Rect: 123, 562, 127, 572 Destination: 199 Annotation: Subtype: Link Rect: 168, 526, 182, 536 Destination: 199 Annotation: Subtype: Link Rect: 147, 490, 154, 500 Destination: 199 Annotation: Subtype: Link Rect: 88, 455, 95, 465 Destination: 199 Annotation: Subtype: Link Rect: 108, 431, 115, 441 Destination: 199 Annotation: Subtype: Link Rect: 117, 431, 124, 441 Destination: 199 Annotation: Subtype: Link Rect: 236, 244, 297, 254 Destination: null Annotation: Subtype: Link Rect: 55, 232, 89, 242 Destination: null Annotation: Subtype: Link Rect: 157, 232, 297, 242 Annotation: Subtype: Link Rect: 55, 220, 107, 230 Annotation: Subtype: Link Rect: 234, 107, 297, 117 Destination: null Annotation: Subtype: Link Rect: 55, 95, 92, 105 Destination: null Annotation: Subtype: Link Rect: 154, 95, 297, 105 Annotation: Subtype: Link Rect: 55, 84, 108, 93 Annotation: Subtype: Link Rect: 403, 641, 437, 651 Destination: 53 Annotation: Subtype: Link Rect: 494, 510, 557, 520 Destination: null Annotation: Subtype: Link Rect: 315, 498, 349, 508 Destination: null Annotation: Subtype: Link Rect: 414, 498, 557, 508 Annotation: Subtype: Link Rect: 315, 486, 368, 496 Annotation: Subtype: Link Rect: 529, 148, 537, 158 Destination: 199 Annotation: Subtype: Link Rect: 131, 15, 482, 24 Annotation: Subtype: Link Rect: 131, 15, 482, 24 Annotation: Subtype: Link Rect: 482, 16, 489, 22 Annotation: Subtype: Link Rect: 489, 15, 494, 24 Annotation: Subtype: Link Rect: 489, 15, 528, 24 Annotation: Subtype: Link Rect: 489, 15, 528, 24 Annotation: Subtype: Link Rect: 528, 16, 534, 22 Annotation: Subtype: Link Rect: 534, 15, 539, 24 Annotation: Subtype: Link Rect: 534, 15, 557, 24 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 58, 36, 90, 46 Destination: 75 Annotation: Subtype: Link Rect: 517, 311, 551, 321 Destination: 75 Annotation: Subtype: Link Rect: 358, 287, 387, 297 Destination: 118 Annotation: Subtype: Link Rect: 502, 227, 534, 237 Destination: 75 Annotation: Subtype: Link Rect: 315, 167, 418, 177 Destination: null Annotation: Subtype: Link Rect: 480, 167, 557, 177 Annotation: Subtype: Link Rect: 315, 155, 430, 165 Annotation: Subtype: Link Rect: 426, 15, 552, 24 Annotation: Subtype: Link Rect: 426, 15, 557, 24 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 224, 173, 256, 183 Destination: 118 Annotation: Subtype: Link Rect: 102, 114, 200, 124 Destination: null Annotation: Subtype: Link Rect: 253, 114, 297, 124 Annotation: Subtype: Link Rect: 55, 102, 194, 112 Annotation: Subtype: Link Rect: 445, 225, 477, 235 Destination: 118 Annotation: Subtype: Link Rect: 417, 189, 449, 199 Destination: 118 Annotation: Subtype: Link Rect: 406, 154, 504, 164 Destination: null Annotation: Subtype: Link Rect: 315, 142, 498, 152 Annotation: Subtype: Link Rect: 365, 118, 460, 128 Destination: null Annotation: Subtype: Link Rect: 512, 118, 557, 128 Annotation: Subtype: Link Rect: 315, 106, 454, 116 Annotation: Subtype: Link Rect: 131, 15, 482, 24 Annotation: Subtype: Link Rect: 131, 15, 482, 24 Annotation: Subtype: Link Rect: 482, 16, 489, 22 Annotation: Subtype: Link Rect: 489, 15, 494, 24 Annotation: Subtype: Link Rect: 489, 15, 528, 24 Annotation: Subtype: Link Rect: 489, 15, 528, 24 Annotation: Subtype: Link Rect: 528, 16, 534, 22 Annotation: Subtype: Link Rect: 534, 15, 539, 24 Annotation: Subtype: Link Rect: 534, 15, 557, 24 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 318, 494, 348, 504 Destination: 118 Annotation: Subtype: Link Rect: 133, 620, 135, 628 Destination: 118 Annotation: Subtype: Link Rect: 159, 556, 162, 563 Destination: 118 Annotation: Subtype: Link Rect: 92, 546, 95, 554 Destination: 118 Annotation: Subtype: Link Rect: 83, 537, 86, 545 Destination: 118 Annotation: Subtype: Link Rect: 137, 445, 140, 453 Destination: 118 Annotation: Subtype: Link Rect: 426, 15, 552, 24 Annotation: Subtype: Link Rect: 426, 15, 557, 24 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 261, 407, 291, 417 Destination: 137 Annotation: Subtype: Link Rect: 58, 192, 88, 202 Destination: 137 Annotation: Subtype: Link Rect: 236, 84, 297, 94 Destination: null Annotation: Subtype: Link Rect: 55, 73, 92, 82 Destination: null Annotation: Subtype: Link Rect: 157, 73, 297, 82 Annotation: Subtype: Link Rect: 55, 61, 107, 71 Annotation: Subtype: Link Rect: 495, 431, 557, 441 Destination: null Annotation: Subtype: Link Rect: 315, 419, 352, 429 Destination: null Annotation: Subtype: Link Rect: 417, 419, 557, 429 Annotation: Subtype: Link Rect: 315, 407, 367, 417 Annotation: Subtype: Link Rect: 529, 624, 532, 631 Destination: 137 Annotation: Subtype: Link Rect: 75, 569, 78, 576 Destination: 137 Annotation: Subtype: Link Rect: 529, 569, 532, 576 Destination: 137 Annotation: Subtype: Link Rect: 529, 550, 532, 558 Destination: 137 Annotation: Subtype: Link Rect: 131, 15, 482, 24 Annotation: Subtype: Link Rect: 131, 15, 482, 24 Annotation: Subtype: Link Rect: 482, 16, 489, 22 Annotation: Subtype: Link Rect: 489, 15, 494, 24 Annotation: Subtype: Link Rect: 489, 15, 528, 24 Annotation: Subtype: Link Rect: 489, 15, 528, 24 Annotation: Subtype: Link Rect: 528, 16, 534, 22 Annotation: Subtype: Link Rect: 534, 15, 539, 24 Annotation: Subtype: Link Rect: 534, 15, 557, 24 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 213, 650, 221, 660 Destination: 199 Annotation: Subtype: Link Rect: 78, 638, 86, 648 Destination: 199 Annotation: Subtype: Link Rect: 139, 506, 146, 516 Destination: 199 Annotation: Subtype: Link Rect: 86, 375, 94, 385 Destination: 199 Annotation: Subtype: Link Rect: 280, 375, 287, 385 Destination: 199 Annotation: Subtype: Link Rect: 289, 375, 297, 385 Destination: 199 Annotation: Subtype: Link Rect: 199, 327, 207, 337 Destination: 199 Annotation: Subtype: Link Rect: 279, 303, 286, 313 Destination: 385 Annotation: Subtype: Link Rect: 84, 208, 92, 217 Destination: 199 Annotation: Subtype: Link Rect: 221, 136, 229, 146 Destination: 385 Annotation: Subtype: Link Rect: 144, 112, 152, 122 Destination: 385 Annotation: Subtype: Link Rect: 154, 112, 161, 122 Destination: 385 Annotation: Subtype: Link Rect: 82, 40, 89, 50 Destination: 385 Annotation: Subtype: Link Rect: 91, 40, 99, 50 Destination: 385 Annotation: Subtype: Link Rect: 426, 15, 552, 24 Annotation: Subtype: Link Rect: 426, 15, 557, 24 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 70, 171, 297, 179 Annotation: Subtype: Link Rect: 70, 161, 210, 169 Annotation: Subtype: Link Rect: 70, 151, 297, 159 Annotation: Subtype: Link Rect: 70, 141, 217, 149 Annotation: Subtype: Link Rect: 239, 131, 297, 139 Annotation: Subtype: Link Rect: 70, 121, 152, 129 Annotation: Subtype: Link Rect: 70, 111, 297, 119 Annotation: Subtype: Link Rect: 70, 101, 211, 109 Annotation: Subtype: Link Rect: 70, 91, 297, 99 Annotation: Subtype: Link Rect: 70, 81, 297, 89 Annotation: Subtype: Link Rect: 70, 71, 163, 79 Annotation: Subtype: Link Rect: 70, 61, 297, 69 Annotation: Subtype: Link Rect: 70, 51, 297, 59 Annotation: Subtype: Link Rect: 329, 719, 557, 727 Annotation: Subtype: Link Rect: 329, 709, 390, 717 Annotation: Subtype: Link Rect: 329, 699, 557, 707 Annotation: Subtype: Link Rect: 329, 689, 557, 697 Annotation: Subtype: Link Rect: 329, 679, 557, 687 Annotation: Subtype: Link Rect: 329, 669, 392, 677 Annotation: Subtype: Link Rect: 329, 659, 557, 667 Annotation: Subtype: Link Rect: 329, 649, 497, 657 Annotation: Subtype: Link Rect: 329, 639, 557, 647 Annotation: Subtype: Link Rect: 329, 629, 557, 637 Annotation: Subtype: Link Rect: 329, 619, 557, 627 Annotation: Subtype: Link Rect: 329, 609, 546, 617 Annotation: Subtype: Link Rect: 329, 599, 557, 607 Annotation: Subtype: Link Rect: 329, 589, 557, 597 Annotation: Subtype: Link Rect: 329, 579, 557, 587 Annotation: Subtype: Link Rect: 329, 569, 557, 577 Annotation: Subtype: Link Rect: 329, 560, 384, 567 Annotation: Subtype: Link Rect: 329, 550, 557, 558 Annotation: Subtype: Link Rect: 329, 540, 557, 548 Annotation: Subtype: Link Rect: 329, 530, 557, 538 Annotation: Subtype: Link Rect: 329, 520, 557, 528 Annotation: Subtype: Link Rect: 329, 510, 404, 518 Annotation: Subtype: Link Rect: 329, 500, 557, 508 Annotation: Subtype: Link Rect: 329, 490, 557, 498 Annotation: Subtype: Link Rect: 329, 480, 557, 488 Annotation: Subtype: Link Rect: 329, 470, 423, 478 Annotation: Subtype: Link Rect: 329, 460, 557, 468 Annotation: Subtype: Link Rect: 329, 450, 557, 458 Annotation: Subtype: Link Rect: 329, 440, 557, 448 Annotation: Subtype: Link Rect: 329, 430, 557, 438 Annotation: Subtype: Link Rect: 329, 420, 404, 428 Annotation: Subtype: Link Rect: 329, 410, 557, 418 Annotation: Subtype: Link Rect: 329, 400, 557, 408 Annotation: Subtype: Link Rect: 329, 390, 557, 398 Annotation: Subtype: Link Rect: 329, 380, 479, 388 Annotation: Subtype: Link Rect: 329, 370, 557, 378 Annotation: Subtype: Link Rect: 329, 360, 557, 368 Annotation: Subtype: Link Rect: 329, 350, 363, 358 Annotation: Subtype: Link Rect: 329, 340, 557, 348 Annotation: Subtype: Link Rect: 329, 330, 557, 338 Annotation: Subtype: Link Rect: 329, 320, 406, 328 Annotation: Subtype: Link Rect: 329, 310, 557, 318 Annotation: Subtype: Link Rect: 329, 300, 557, 308 Annotation: Subtype: Link Rect: 329, 291, 444, 298 Annotation: Subtype: Link Rect: 329, 281, 557, 289 Annotation: Subtype: Link Rect: 329, 271, 557, 279 Annotation: Subtype: Link Rect: 329, 261, 557, 269 Annotation: Subtype: Link Rect: 329, 251, 557, 259 Annotation: Subtype: Link Rect: 329, 241, 443, 249 Annotation: Subtype: Link Rect: 329, 231, 557, 239 Annotation: Subtype: Link Rect: 329, 221, 557, 229 Annotation: Subtype: Link Rect: 329, 211, 557, 219 Annotation: Subtype: Link Rect: 329, 201, 416, 209 Annotation: Subtype: Link Rect: 329, 191, 557, 199 Annotation: Subtype: Link Rect: 329, 181, 557, 189 Annotation: Subtype: Link Rect: 329, 171, 557, 179 Annotation: Subtype: Link Rect: 329, 161, 496, 169 Annotation: Subtype: Link Rect: 329, 151, 557, 159 Annotation: Subtype: Link Rect: 329, 141, 557, 149 Annotation: Subtype: Link Rect: 329, 131, 557, 139 Annotation: Subtype: Link Rect: 329, 121, 355, 129 Annotation: Subtype: Link Rect: 329, 111, 557, 119 Annotation: Subtype: Link Rect: 329, 101, 557, 109 Annotation: Subtype: Link Rect: 329, 91, 557, 99 Annotation: Subtype: Link Rect: 329, 81, 363, 89 Annotation: Subtype: Link Rect: 329, 71, 437, 79 Annotation: Subtype: Link Rect: 441, 71, 557, 79 Annotation: Subtype: Link Rect: 329, 61, 557, 69 Annotation: Subtype: Link Rect: 329, 51, 517, 59 Annotation: Subtype: Link Rect: 131, 15, 482, 24 Annotation: Subtype: Link Rect: 131, 15, 482, 24 Annotation: Subtype: Link Rect: 482, 16, 489, 22 Annotation: Subtype: Link Rect: 489, 15, 494, 24 Annotation: Subtype: Link Rect: 489, 15, 528, 24 Annotation: Subtype: Link Rect: 489, 15, 528, 24 Annotation: Subtype: Link Rect: 528, 16, 534, 22 Annotation: Subtype: Link Rect: 534, 15, 539, 24 Annotation: Subtype: Link Rect: 534, 15, 557, 24 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 69, 719, 297, 727 Annotation: Subtype: Link Rect: 69, 709, 297, 717 Annotation: Subtype: Link Rect: 69, 699, 219, 707 Annotation: Subtype: Link Rect: 69, 689, 297, 697 Annotation: Subtype: Link Rect: 69, 679, 297, 687 Annotation: Subtype: Link Rect: 69, 669, 297, 677 Annotation: Subtype: Link Rect: 69, 659, 173, 667 Annotation: Subtype: Link Rect: 69, 649, 297, 657 Annotation: Subtype: Link Rect: 69, 639, 297, 647 Annotation: Subtype: Link Rect: 69, 629, 297, 637 Annotation: Subtype: Link Rect: 69, 619, 236, 627 Annotation: Subtype: Link Rect: 329, 719, 557, 727 Annotation: Subtype: Link Rect: 329, 709, 557, 717 Annotation: Subtype: Link Rect: 329, 699, 496, 707 Annotation: Subtype: Link Rect: 329, 689, 557, 697 Annotation: Subtype: Link Rect: 329, 679, 557, 687 Annotation: Subtype: Link Rect: 329, 669, 557, 677 Annotation: Subtype: Link Rect: 329, 659, 496, 667 Annotation: Subtype: Link Rect: 329, 649, 557, 657 Annotation: Subtype: Link Rect: 329, 639, 557, 647 Annotation: Subtype: Link Rect: 329, 629, 557, 637 Annotation: Subtype: Link Rect: 329, 619, 443, 627 Annotation: Subtype: Link Rect: 426, 15, 552, 24 Annotation: Subtype: Link Rect: 426, 15, 557, 24 Checksum: 5299de3a Type: CRC32 Checksum: 185e9b94ddd3c4e2d968c59cbd9802c9 Type: MD5 Checksum: d64519a3b3b4e3ff42e401ff791eae53967f0a73 Type: SHA-1 Checksum: 64507722bf7fe6f4eb14e5341784927bcbf4c21a0f84bf9535929f2f4664880f Type: SHA-256