006effe28498f0341840a1eab1af12cc 305616.pdf a4e8e7354d2ca0610a6680b782dacade63114d21 305616.pdf 9c38326d8de317d3812c1ec4c4a85160386fa93e26ae53f0176adaa91d6a2e22 305616.pdf Title: Factors Associated with Non-Adherence to Tuberculosis Preventive Treatment among Adult Contacts of Pulmonary Tuberculosis Cases with Latent Tuberculosis Infection in Catalonia, Spain, in 2019-2021 Subject: The aim of this study was to identify factors associated with non-adherence to tuberculosis (TB) preventive treatment among contacts with latent TB infection for new cases of pulmonary TB cases reported in Catalonia in 2019–2021. All contacts aged 18 years or older with a latent TB infection who received a TB preventive treatment were included in the study. The Chi square test and the odds ratios (OR) were used to assess the association between non-adherence to TB preventive treatment and the study variables; a p < 0.05 was considered statistically significant. Multiple logistic regression analysis was used to detect the independent factors associated with TB preventive treatment non-adherence; a p < 0.05 was considered statistically significant. The percentage of non-adherence to TB preventive treatment found in this study was 23.7%. A multivariable logistic regression analysis determined that the following factors were significantly associated with TB preventive treatment non-adherence among adult contacts: “exposure at school or workplace” (aOR = 3.34), “exposure to an index case without laboratory confirmation of TB” (aOR = 2.07), “immigrant contact” (aOR = 1.81), “male gender” (aOR = 1.75) and “exposure duration < 6 h per week or sporadic” (aOR = 1.60. By contrast, the factor “short-term TB preventive treatment regimen” (aOR = 0.38) was significantly associated with a lower treatment non-adherence. Adherence to TB preventive treatment should be improved among adult contacts of TB pulmonary cases with latent TB infection by recommending short-term treatment regimens and by developing health education activities, with a greater focus on contacts with factors associated with treatment non-adherence. Keywords: latent tuberculosis infection; tuberculosis; non-adherence to LTBI treatment; factors of treatment non-adherence; community health Author: Pedro Plans-Rubió, Sofia Godoy, Diana Toledo, Angela Domínguez, Joan Caylà, Ignasi Parron, Joan Pau Millet and Pere Godoy Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Tue Feb 27 12:50:11 2024 CET ModDate: Tue Feb 27 12:54:10 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 610662 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- RSYDPD+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 RXEGVR+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 YJABHH+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 CNXSVA+CMSY10 Type 1 Builtin yes yes yes 27 0 OMHXGB+URWPalladioL-Ital Type 1 Custom yes yes yes 32 0 HYYHEA+CMBSY10 Type 1 Builtin yes yes yes 37 0 EUNBMT+VnURWPalladioL Type 1 Custom yes yes yes 42 0 ZMZZBL+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 58 0 AEBBVM+EURM10 Type 1 Builtin yes yes yes 81 0 ACIEDM+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 93 0 ACIEDN+PalatinoLinotype CID TrueType Identity-H yes yes yes 96 0 ACIEDO+PalatinoLinotype TrueType WinAnsi yes yes no 102 0 ACIEEA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 105 0 ACIEJA+PalatinoLinotype TrueType MacRoman yes yes no 108 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 121 0 FHDTYR+VnURWPalladioL-Italic Type 1 Custom yes yes yes 142 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-01-15 02:42:04 CET RepresentationInformation: 305616.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-01-14 09:18:30 CET Size: 610662 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 367 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Data Collection Destination: subsection.2.2 Item: Title: Data Analysis Destination: subsection.2.3 Item: Title: Bivariate Correlation among Study Variables Destination: subsection.2.4 Item: Title: Multivariate Logistic Regression Analysis Destination: subsection.2.5 Item: Title: Results Destination: section.3 Children: Item: Title: Population Studied Destination: subsection.3.1 Item: Title: Non-Adherence to TB Preventive Treatement Destination: subsection.3.2 Item: Title: Bivariate Correlation among Study Variables Destination: subsection.3.3 Item: Title: Multivariate Logistic Regression Analysis Destination: subsection.3.4 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: appendix.A. Info: Title: Factors Associated with Non-Adherence to Tuberculosis Preventive Treatment among Adult Contacts of Pulmonary Tuberculosis Cases with Latent Tuberculosis Infection in Catalonia, Spain, in 2019-2021 Author: Pedro Plans-Rubió, Sofia Godoy, Diana Toledo, Angela Domínguez, Joan Caylà, Ignasi Parron, Joan Pau Millet and Pere Godoy Subject: The aim of this study was to identify factors associated with non-adherence to tuberculosis (TB) preventive treatment among contacts with latent TB infection for new cases of pulmonary TB cases reported in Catalonia in 2019 2021. All contacts aged 18 years or older with a latent TB infection who received a TB preventive treatment were included in the study. The Chi square test and the odds ratios (OR) were used to assess the association between non-adherence to TB preventive treatment and the study variables; a p < 0.05 was considered statistically significant. Multiple logistic regression analysis was used to detect the independent factors associated with TB preventive treatment non-adherence; a p < 0.05 was considered statistically significant. The percentage of non-adherence to TB preventive treatment found in this study was 23.7%. A multivariable logistic regression analysis determined that the following factors were significantly associated with TB preventive treatment non-adherence among adult contacts: “exposure at school or workplace” (aOR = 3.34), “exposure to an index case without laboratory confirmation of TB” (aOR = 2.07), “immigrant contact” (aOR = 1.81), “male gender” (aOR = 1.75) and “exposure duration < 6 h per week or sporadic” (aOR = 1.60. By contrast, the factor “short-term TB preventive treatment regimen” (aOR = 0.38) was significantly associated with a lower treatment non-adherence. Adherence to TB preventive treatment should be improved among adult contacts of TB pulmonary cases with latent TB infection by recommending short-term treatment regimens and by developing health education activities, with a greater focus on contacts with factors associated with treatment non-adherence. 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