9a7c4afb2008ba77dde296acc6159ee2 305623.pdf e8728c1ea87f794ff2cf1aa7d5ffee3cc78b3e6e 305623.pdf 2e9cb69d20e51ec5304c4ca901c8bb188a79b47d9a2d1e7fee2d33b9d50362c6 305623.pdf Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Mar 8 01:49:28 2024 CET ModDate: Fri Mar 8 01:49:29 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 359910 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YLSDEM+ArialMT CID TrueType Identity-H yes yes yes 365 0 SLZBYY+HelveticaNeueLTStd-BdCn Type 1C Custom yes yes yes 343 0 KNVCQO+HelveticaNeueLTStd-Bd Type 1C WinAnsi yes yes yes 344 0 VWGLOS+HelveticaNeueLTStd-Roman Type 1C Custom yes yes yes 345 0 TTHZMW+HelveticaLTStd-BoldCond Type 1C WinAnsi yes yes yes 356 0 UOYNAU+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 357 0 TKOHMW+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 358 0 LPEYEM+NewBaskerville-Roman Type 1C WinAnsi yes yes yes 372 0 AWUKGI+Symbol Type 1C Custom yes yes yes 373 0 RIKSKA+BookAntiqua-Bold TrueType WinAnsi yes yes yes 351 0 UOYNAU+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 417 0 TKOHMW+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 419 0 SLZBYY+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 421 0 ZSFESK+SymbolMT CID TrueType Identity-H yes yes yes 240 0 UOYNAU+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 241 0 TKOHMW+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 244 0 SLZBYY+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 231 0 XKCNQO+NewBaskerville-Italic Type 1C WinAnsi yes yes yes 248 0 UOYNAU+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 55 0 TKOHMW+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 57 0 SLZBYY+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 59 0 UOYNAU+HelveticaNeueLTStd-Cn Type 1C Custom yes yes yes 250 0 TKOHMW+HelveticaNeueLTStd-CnO Type 1C Custom yes yes yes 253 0 SLZBYY+HelveticaNeueLTStd-BdCn Type 1C WinAnsi yes yes yes 252 0 RBADKA+HelveticaNeueLTStd-It Type 1C Custom yes yes yes 259 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-01-15 02:41:54 CET RepresentationInformation: 305623.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-01-14 09:55:32 CET Size: 359910 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 434 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Multicentre randomised trial of screening with sFlt1/PlGF and planned delivery to prevent pre-­eclampsia at term: protocol of the PE37 study Children: Item: Title: Abstract Item: Title: Introduction Children: Item: Title: Background and rationale Item: Title: Justification of the study Item: Title: Hypothesis Item: Title: Objectives Children: Item: Title: Primary Item: Title: Secondary outcomes Item: Title: Methods Children: Item: Title: Study design Item: Title: Participants Item: Title: Randomisation Item: Title: Sample size Item: Title: Study intervention Children: Item: Title: The 90th centile of sFlt1/PlGF ratio Item: Title: Outcomes and measures Children: Item: Title: Primary Item: Title: Secondary Item: Title: Exploratory outcomes Item: Title: Study timeline Item: Title: Statistical analyses Item: Title: Data collection and access Item: Title: Protocol modification Item: Title: Patient and public involvement statement Item: Title: Safety issues Item: Title: Scientific dissemination plan Item: Title: Data sharing plan Item: Title: Ethical approval Item: Title: References Info: Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Fri Mar 08 02:19:28 CET 2024 ModDate: Fri Mar 08 02:19:29 CET 2024 ID: 0x9c1a3e46c0260448bd5ebbfd42fd1073, 0x5153d383b425204bbc37596ed4035ab8 Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: ZSFESK+SymbolMT Encoding: Identity-H ToUnicode: true Font: BaseFont: YLSDEM+ArialMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: RBADKA+HelveticaNeueLTStd-It FontSubset: true FirstChar: 31 LastChar: 121 FontDescriptor: FontName: RBADKA+HelveticaNeueLTStd-It Flags: Nonsymbolic, Italic FontBBox: -166, -214, 1106, 957 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: LPEYEM+NewBaskerville-Roman FontSubset: true FirstChar: 32 LastChar: 215 FontDescriptor: FontName: LPEYEM+NewBaskerville-Roman Flags: Serif, Nonsymbolic FontBBox: -205, -272, 1207, 906 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: TTHZMW+HelveticaLTStd-BoldCond FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: TTHZMW+HelveticaLTStd-BoldCond Flags: Nonsymbolic FontBBox: -169, -250, 1091, 991 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: AWUKGI+Symbol FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: AWUKGI+Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UOYNAU+HelveticaNeueLTStd-Cn FontSubset: true FirstChar: 30 LastChar: 237 FontDescriptor: FontName: UOYNAU+HelveticaNeueLTStd-Cn Flags: Nonsymbolic FontBBox: -164, -212, 1000, 932 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TKOHMW+HelveticaNeueLTStd-CnO FontSubset: true FirstChar: 31 LastChar: 116 FontDescriptor: FontName: TKOHMW+HelveticaNeueLTStd-CnO Flags: Nonsymbolic, Italic FontBBox: -171, -272, 1068, 932 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SLZBYY+HelveticaNeueLTStd-BdCn FontSubset: true FirstChar: 31 LastChar: 122 FontDescriptor: FontName: SLZBYY+HelveticaNeueLTStd-BdCn Flags: Nonsymbolic FontBBox: -164, -224, 1066, 961 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KNVCQO+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: KNVCQO+HelveticaNeueLTStd-Bd Flags: Nonsymbolic FontBBox: -166, -218, 1078, 975 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: XKCNQO+NewBaskerville-Italic FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: XKCNQO+NewBaskerville-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -138, -274, 1347, 906 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: VWGLOS+HelveticaNeueLTStd-Roman FontSubset: true FirstChar: 31 LastChar: 246 FontDescriptor: FontName: VWGLOS+HelveticaNeueLTStd-Roman Flags: Nonsymbolic FontBBox: -166, -214, 1076, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: RIKSKA+BookAntiqua-Bold FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: RIKSKA+BookAntiqua-Bold Flags: Serif, Nonsymbolic FontBBox: -134, -337, 1193, 1021 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: ZSFESK+SymbolMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ZSFESK+SymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile2: true Font: BaseFont: YLSDEM+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: YLSDEM+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1006 FontFile2: true XMP: doi:bmjopen-2023-076201 application/pdf 2024-03-08T06:19:28+05:30 2024-03-08T06:19:29+05:30 2024-03-08T06:19:29+05:30 Adobe InDesign 15.1 (Windows) uuid:6202ba77-7dbb-4e07-9c79-44d76d49384f xmp.did:B2C59A163194E611BD009A7CB80B8EC7 xmp.id:3a6ff773-2556-e147-9505-dea860c996a0 proof:pdf xmp.iid:6c6b3f44-dc2d-264d-b352-76b5eb43dd51 xmp.did:934cc50e-cd72-c749-ab6a-350be46d6b3d xmp.did:B2C59A163194E611BD009A7CB80B8EC7 default converted from application/x-indesign to application/pdf Adobe InDesign 15.1 (Windows) / 2024-03-08T06:19:28+05:30 5af65549-d22f-4d3f-b896-884b882a3323 Adobe PDF Library 15.0 False Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 38, 34, 63, 18 Annotation: Subtype: Link Rect: 391, 622, 400, 609 Annotation: Subtype: Link Rect: 426, 596, 435, 583 Annotation: Subtype: Link Rect: 476, 570, 485, 557 Annotation: Subtype: Link Rect: 62, 363, 133, 354 Annotation: Subtype: Link Rect: 40, 353, 110, 344 Annotation: Subtype: Link Rect: 38, 197, 134, 174 Annotation: Subtype: Link Rect: 451, 209, 499, 199 Annotation: Subtype: Link Rect: 441, 111, 444, 99 ActionDest: 103 Annotation: Subtype: Link Rect: 551, 99, 554, 87 ActionDest: 103 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 117, 747, 120, 735 ActionDest: 103 Annotation: Subtype: Link Rect: 119, 735, 123, 723 ActionDest: 103 Annotation: Subtype: Link Rect: 95, 711, 99, 699 ActionDest: 103 Annotation: Subtype: Link Rect: 148, 699, 152, 687 ActionDest: 103 Annotation: Subtype: Link Rect: 159, 639, 169, 627 ActionDest: 103 Annotation: Subtype: Link Rect: 82, 591, 89, 579 ActionDest: 103 Annotation: Subtype: Link Rect: 147, 579, 154, 567 ActionDest: 103 Annotation: Subtype: Link Rect: 94, 531, 101, 519 ActionDest: 103 Annotation: Subtype: Link Rect: 194, 507, 200, 495 ActionDest: 103 Annotation: Subtype: Link Rect: 60, 471, 76, 459 ActionDest: 103 Annotation: Subtype: Link Rect: 142, 435, 149, 423 ActionDest: 103 Annotation: Subtype: Link Rect: 207, 303, 214, 291 ActionDest: 160 Annotation: Subtype: Link Rect: 149, 291, 155, 279 ActionDest: 160 Annotation: Subtype: Link Rect: 272, 267, 288, 255 ActionDest: 160 Annotation: Subtype: Link Rect: 243, 183, 259, 171 ActionDest: 160 Annotation: Subtype: Link Rect: 55, 147, 72, 135 ActionDest: 160 Annotation: Subtype: Link Rect: 242, 99, 249, 87 ActionDest: 160 Annotation: Subtype: Link Rect: 521, 723, 528, 711 ActionDest: 160 Annotation: Subtype: Link Rect: 491, 592, 498, 581 ActionDest: 160 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 121, 477, 233, 465 Annotation: Subtype: Link Rect: 281, 216, 288, 204 ActionDest: 160 Annotation: Subtype: Link Rect: 203, 108, 210, 96 ActionDest: 160 Annotation: Subtype: Link Rect: 498, 243, 505, 231 ActionDest: 160 Annotation: Subtype: Link Rect: 543, 231, 550, 219 ActionDest: 160 Annotation: Subtype: Link Rect: 524, 219, 531, 207 ActionDest: 160 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 176, 687, 183, 675 ActionDest: 160 Annotation: Subtype: Link Rect: 281, 638, 288, 627 ActionDest: 160 Annotation: Subtype: Link Rect: 281, 325, 288, 313 ActionDest: 160 Annotation: Subtype: Link Rect: 82, 241, 89, 229 ActionDest: 160 Annotation: Subtype: Link Rect: 77, 160, 84, 148 ActionDest: 160 Annotation: Subtype: Link Rect: 255, 160, 262, 148 ActionDest: 160 Annotation: Subtype: Link Rect: 148, 99, 155, 88 ActionDest: 160 Annotation: Subtype: Link Rect: 481, 339, 488, 327 ActionDest: 160 Annotation: Subtype: Link Rect: 306, 306, 436, 294 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 121, 623, 128, 611 ActionDest: 160 Annotation: Subtype: Link Rect: 257, 611, 263, 599 ActionDest: 160 Annotation: Subtype: Link Rect: 252, 399, 288, 387 Annotation: Subtype: Link Rect: 40, 387, 125, 375 Annotation: Subtype: Link Rect: 63, 300, 175, 288 Annotation: Subtype: Link Rect: 393, 175, 514, 163 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 122, 294, 173, 285 Annotation: Subtype: Link Rect: 215, 294, 264, 285 Annotation: Subtype: Link Rect: 105, 285, 139, 275 Annotation: Subtype: Link Rect: 380, 505, 521, 496 Annotation: Subtype: Link Rect: 365, 478, 481, 469 Annotation: Subtype: Link Rect: 345, 468, 462, 459 Annotation: Subtype: Link Rect: 362, 459, 478, 450 Annotation: Subtype: Link Rect: 525, 401, 548, 392 Annotation: Subtype: Link Rect: 322, 393, 352, 384 Annotation: Subtype: Link Rect: 412, 376, 476, 367 Annotation: Subtype: Link Rect: 322, 350, 338, 341 Annotation: Subtype: Link Rect: 498, 333, 547, 324 Annotation: Subtype: Link Rect: 322, 325, 354, 316 Annotation: Subtype: Link Rect: 505, 316, 529, 307 Annotation: Subtype: Link Rect: 322, 308, 349, 299 Annotation: Subtype: Link Rect: 437, 282, 470, 273 Annotation: Subtype: Link Rect: 521, 265, 540, 256 Annotation: Subtype: Link Rect: 322, 257, 374, 248 Annotation: Subtype: Link Rect: 356, 231, 453, 222 Annotation: Subtype: Link Rect: 322, 214, 345, 205 Annotation: Subtype: Link Rect: 322, 197, 409, 188 Annotation: Subtype: Link Rect: 371, 172, 383, 163 Annotation: Subtype: Link Rect: 523, 155, 542, 146 Annotation: Subtype: Link Rect: 322, 146, 374, 137 Annotation: Subtype: Link Rect: 493, 129, 538, 120 Annotation: Subtype: Link Rect: 487, 104, 523, 95 Annotation: Subtype: Link Rect: 435, 70, 532, 61 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 241, 738, 286, 729 Annotation: Subtype: Link Rect: 163, 713, 261, 704 Annotation: Subtype: Link Rect: 56, 695, 226, 687 Annotation: Subtype: Link Rect: 56, 670, 147, 661 Annotation: Subtype: Link Rect: 138, 645, 210, 636 Annotation: Subtype: Link Rect: 187, 628, 261, 619 Annotation: Subtype: Link Rect: 94, 602, 138, 593 Annotation: Subtype: Link Rect: 231, 585, 276, 576 Annotation: Subtype: Link Rect: 159, 551, 195, 542 Annotation: Subtype: Link Rect: 56, 526, 92, 517 Annotation: Subtype: Link Rect: 121, 500, 211, 491 Annotation: Subtype: Link Rect: 183, 475, 274, 466 Annotation: Subtype: Link Rect: 142, 432, 255, 423 Annotation: Subtype: Link Rect: 322, 730, 413, 721 Annotation: Subtype: Link Rect: 515, 713, 547, 704 Annotation: Subtype: Link Rect: 322, 704, 337, 695 Annotation: Subtype: Link Rect: 479, 687, 517, 678 Annotation: Subtype: Link Rect: 427, 670, 474, 661 Annotation: Subtype: Link Rect: 349, 636, 392, 627 Annotation: Subtype: Link Rect: 367, 611, 473, 602 Annotation: Subtype: Link Rect: 484, 602, 524, 593 Annotation: Subtype: Link Rect: 322, 594, 416, 585 Annotation: Subtype: Link Rect: 522, 568, 538, 559 Annotation: Subtype: Link Rect: 322, 560, 399, 551 Annotation: Subtype: Link Rect: 358, 534, 412, 525 Annotation: Subtype: Link Rect: 397, 509, 487, 500 Annotation: Subtype: Link Rect: 424, 500, 536, 491 Annotation: Subtype: Link Rect: 322, 491, 358, 483 Annotation: Subtype: Link Rect: 512, 474, 536, 466 Annotation: Subtype: Link Rect: 322, 466, 543, 457 Annotation: Subtype: Link Rect: 322, 457, 385, 449 Annotation: Subtype: Link Rect: 477, 440, 537, 432 Annotation: Subtype: Link Rect: 322, 432, 538, 423 Annotation: Subtype: Link Rect: 322, 423, 352, 415 Checksum: 7a649f3b Type: CRC32 Checksum: 9a7c4afb2008ba77dde296acc6159ee2 Type: MD5 Checksum: e8728c1ea87f794ff2cf1aa7d5ffee3cc78b3e6e Type: SHA-1 Checksum: 2e9cb69d20e51ec5304c4ca901c8bb188a79b47d9a2d1e7fee2d33b9d50362c6 Type: SHA-256