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Title:           Reversion of metabolic dysfunction-associated steatohepatitis by skeletal muscle-directed FGF21 gene therapy
Subject:         Molecular Therapy, 32 (2024) 4285-4302. doi:10.1016/j.ymthe.2024.10.023
Author:          Veronica Jimenez
Creator:         Elsevier
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      Title: Reversion of metabolic dysfunction-associated steatohepatitis by skeletal muscle-directed FGF21 gene therapy
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        Title: Introduction
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       Item: 
        Title: Results
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         Item: 
          Title: High-fat diet feeding induces MASH in mice
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          Title: Reversal of hepatic steatosis in HFD-fed mice after IM administration of AAV-FGF21
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          Title: Treatment with AAV-FGF21 reverts hepatic inflammation and fibrosis and halts development of liver tumors
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          Title: AAV-FGF21 treatment mediates reversal of WAT hypertrophy and inflammation
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         Item: 
          Title: AAV-FGF21 gene therapy increases energy expenditure
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         Item: 
          Title: Improved insulin sensitivity by AAV-FGF21 gene therapy
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         Item: 
          Title: AAV-FGF21 treatment improves neuromuscular performance and cognition in HFD-fed mice
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         Item: 
          Title: Treatment of Beagle dogs with AAV-FGF21 vectors
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         Item: 
          Title: Analysis of circulating FGF21 levels in obese, T2D, and MASH patients
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        Title: Discussion
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          Title: Recombinant AAV vectors
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          Title: AAV-FGF21 IM administration
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          Title: ITT
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          Title: Indirect calorimetry
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          Title: Open-field test
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          Title: Vector genome copy number
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          Title: Histology and immunohistochemistry
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        Title: Declaration of interests
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    Title: Reversion of metabolic dysfunction-associated steatohepatitis by skeletal muscle-directed FGF21 gene therapy
    Author: Veronica Jimenez
    Subject: Molecular Therapy, 32 (2024) 4285-4302. doi:10.1016/j.ymthe.2024.10.023
    Creator: Elsevier
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