f98a936f627abda5b356f011ac435a98 305664.pdf 6283e9ccffeb5fa672cc323f06e530f9d53ee57c 305664.pdf 29892ea1667381fa3e433bf7955fd235cc49d83f0c651a29439016ba5bb2c5f3 305664.pdf Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Mon Nov 11 11:40:03 2024 CET ModDate: Mon Nov 11 11:40:05 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1625582 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XTZRQD+ArialMT CID TrueType Identity-H yes yes yes 451 0 KZWAVD+FrutigerLTPro-LightCn Type 1C Custom yes yes yes 427 0 YVNWJB+FrutigerLTPro-BoldCn Type 1C Custom yes yes yes 428 0 FWJHYN+FrutigerLTPro-Condensed Type 1C Custom yes yes yes 429 0 DTKVWR+FrutigerLTPro-CondensedIta Type 1C WinAnsi yes yes yes 430 0 JOCKHF+FrutigerLTPro-LightCnIta Type 1C Custom yes yes yes 448 0 SJMNYN+Symbol Type 1C Custom yes yes yes 458 0 KZWAVD+FrutigerLTPro-LightCn Type 1C Custom yes yes yes 551 0 JOCKHF+FrutigerLTPro-LightCnIta Type 1C Custom yes yes yes 553 0 YVNWJB+FrutigerLTPro-BoldCn Type 1C WinAnsi yes yes yes 555 0 QBJWWR+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 337 0 LRWSEB+FrutigerLTPro-BoldCnIta Type 1C WinAnsi yes yes yes 335 0 SJMNYN+ClassicalGaramondBT-Italic TrueType WinAnsi yes yes yes 334 0 BUYKUV+ClassicalGaramondBT-Roman TrueType WinAnsi yes yes yes 338 0 NGGFGX+FrutigerLTStd-BoldCn Type 1C WinAnsi yes yes yes 341 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-01-09 02:40:21 CET RepresentationInformation: 305664.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-01-08 15:32:49 CET Size: 1625582 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 596 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Evolution of the use, effectiveness and safety of bismuth-­containing quadruple therapy for Helicobacter pylori infection between 2013 and 2021: results from the European registry on H. pylori management (Hp-­EuReg) Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Methods Children: Item: Title: European registry on Helicobacter pylori management Item: Title: Participants Item: Title: Data management Item: Title: Statistical analysis Children: Item: Title: Categorisation and definition of variables Item: Title: Data analysis Item: Title: Results Children: Item: Title: Trends in the use of bismuth-based therapy in Europe Item: Title: Use and effectiveness of BQT according to treatment line, length of treatment, PPI dose, European region and year Item: Title: Multivariate analysis Item: Title: Adherence and safety Item: Title: Discussion Item: Title: References Info: Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Mon Nov 11 12:10:03 CET 2024 ModDate: Mon Nov 11 12:10:05 CET 2024 ID: 0xb6e684b451b0ef40b6aee33aa194f866, 0xcbd2a5fac7e97649af811cb29e5ed63c Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 678 ImageHeight: 414 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 720 ImageHeight: 540 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 715 ImageHeight: 540 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: QBJWWR+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: XTZRQD+ArialMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: JOCKHF+FrutigerLTPro-LightCnIta FontSubset: true FirstChar: 30 LastChar: 121 FontDescriptor: FontName: JOCKHF+FrutigerLTPro-LightCnIta Flags: Nonsymbolic FontBBox: -161, -250, 991, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NGGFGX+FrutigerLTStd-BoldCn FontSubset: true FirstChar: 67 LastChar: 83 FontDescriptor: FontName: NGGFGX+FrutigerLTStd-BoldCn Flags: Nonsymbolic FontBBox: -112, -250, 1000, 940 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: SJMNYN+Symbol FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: SJMNYN+Symbol Flags: Symbolic FontBBox: -180, -293, 1090, 1010 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KZWAVD+FrutigerLTPro-LightCn FontSubset: true FirstChar: 24 LastChar: 252 FontDescriptor: FontName: KZWAVD+FrutigerLTPro-LightCn Flags: Nonsymbolic FontBBox: -100, -250, 1000, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YVNWJB+FrutigerLTPro-BoldCn FontSubset: true FirstChar: 31 LastChar: 239 FontDescriptor: FontName: YVNWJB+FrutigerLTPro-BoldCn Flags: Nonsymbolic FontBBox: -112, -250, 1000, 940 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FWJHYN+FrutigerLTPro-Condensed FontSubset: true FirstChar: 29 LastChar: 239 FontDescriptor: FontName: FWJHYN+FrutigerLTPro-Condensed Flags: Nonsymbolic FontBBox: -105, -250, 1000, 929 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: DTKVWR+FrutigerLTPro-CondensedIta FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: DTKVWR+FrutigerLTPro-CondensedIta Flags: Nonsymbolic, Italic FontBBox: -166, -250, 992, 929 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: LRWSEB+FrutigerLTPro-BoldCnIta FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: LRWSEB+FrutigerLTPro-BoldCnIta Flags: Nonsymbolic FontBBox: -173, -250, 1012, 940 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true TrueType: Font: BaseFont: BUYKUV+ClassicalGaramondBT-Roman FontSubset: true FirstChar: 32 LastChar: 243 FontDescriptor: FontName: BUYKUV+ClassicalGaramondBT-Roman Flags: Serif, Nonsymbolic FontBBox: -166, -237, 1261, 963 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: SJMNYN+ClassicalGaramondBT-Italic FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: SJMNYN+ClassicalGaramondBT-Italic Flags: Serif, Nonsymbolic FontBBox: -167, -237, 1275, 963 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: XTZRQD+ArialMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: XTZRQD+ArialMT Flags: Symbolic FontBBox: -665, -325, 2000, 1006 FontFile2: true Font: BaseFont: QBJWWR+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: QBJWWR+TimesNewRomanPSMT Flags: Serif, Symbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true XMP: doi:gutjnl-2024-332804 application/pdf 2024-11-11T16:10:03+05:30 2024-11-11T16:10:05+05:30 2024-11-11T16:10:05+05:30 Adobe InDesign 15.1 (Windows) uuid:ec05b3aa-fcb4-44f0-a4a4-0f4cf535d32b xmp.did:F77F1174072068118083DB6ECE62542A xmp.id:42593866-a93d-3e4a-89e5-af76a0ad418a proof:pdf converted from application/x-indesign to application/pdf Adobe InDesign 15.1 (Windows) / 2024-11-11T16:10:03+05:30 xmp.iid:564fbe80-a651-2840-9a3c-a25ec186f367 xmp.did:331d13d6-3891-3c46-90e4-fa93b3f08360 xmp.did:F77F1174072068118083DB6ECE62542A default a9cd30d9-fc61-47b8-9bed-beeb369b5fac Adobe PDF Library 15.0 False Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 487, 36, 539, 18 Annotation: Subtype: Link Rect: 40, 34, 93, 19 Annotation: Subtype: Link Rect: 214, 624, 223, 608 Annotation: Subtype: Link Rect: 318, 624, 327, 608 Annotation: Subtype: Link Rect: 404, 624, 413, 608 Annotation: Subtype: Link Rect: 519, 624, 528, 608 Annotation: Subtype: Link Rect: 464, 608, 473, 593 Annotation: Subtype: Link Rect: 343, 592, 352, 577 Annotation: Subtype: Link Rect: 470, 592, 479, 577 Annotation: Subtype: Link Rect: 405, 577, 414, 562 Annotation: Subtype: Link Rect: 377, 546, 386, 531 Annotation: Subtype: Link Rect: 224, 531, 233, 515 Annotation: Subtype: Link Rect: 335, 531, 344, 515 Annotation: Subtype: Link Rect: 454, 531, 463, 515 Annotation: Subtype: Link Rect: 314, 515, 323, 500 Annotation: Subtype: Link Rect: 402, 515, 411, 500 Annotation: Subtype: Link Rect: 526, 515, 535, 500 Annotation: Subtype: Link Rect: 253, 499, 262, 484 Annotation: Subtype: Link Rect: 362, 499, 371, 484 Annotation: Subtype: Link Rect: 471, 499, 480, 484 Annotation: Subtype: Link Rect: 295, 484, 304, 469 Annotation: Subtype: Link Rect: 231, 468, 240, 453 Annotation: Subtype: Link Rect: 359, 468, 368, 453 Annotation: Subtype: Link Rect: 466, 468, 475, 453 Annotation: Subtype: Link Rect: 243, 453, 252, 437 Annotation: Subtype: Link Rect: 350, 453, 359, 437 Annotation: Subtype: Link Rect: 489, 453, 498, 437 Annotation: Subtype: Link Rect: 268, 437, 277, 422 Annotation: Subtype: Link Rect: 471, 437, 480, 422 Annotation: Subtype: Link Rect: 203, 421, 212, 406 Annotation: Subtype: Link Rect: 313, 421, 322, 406 Annotation: Subtype: Link Rect: 426, 421, 435, 406 Annotation: Subtype: Link Rect: 219, 406, 228, 391 Annotation: Subtype: Link Rect: 224, 390, 233, 375 Annotation: Subtype: Link Rect: 85, 320, 128, 311 Annotation: Subtype: Link Rect: 42, 311, 128, 302 Annotation: Subtype: Link Rect: 40, 189, 136, 166 Annotation: Subtype: Link Rect: 459, 64, 510, 53 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 85, 428, 89, 417 ActionDest: 180 Annotation: Subtype: Link Rect: 234, 395, 237, 384 ActionDest: 180 Annotation: Subtype: Link Rect: 106, 373, 109, 362 ActionDest: 180 Annotation: Subtype: Link Rect: 250, 340, 260, 329 ActionDest: 180 Annotation: Subtype: Link Rect: 117, 307, 125, 296 ActionDest: 262 Annotation: Subtype: Link Rect: 220, 186, 223, 175 ActionDest: 180 Annotation: Subtype: Link Rect: 167, 153, 180, 142 ActionDest: 262 Annotation: Subtype: Link Rect: 159, 120, 178, 109 ActionDest: 180 Annotation: Subtype: Link Rect: 160, 76, 166, 65 ActionDest: 262 Annotation: Subtype: Link Rect: 92, 54, 98, 43 ActionDest: 262 Annotation: Subtype: Link Rect: 378, 703, 390, 692 ActionDest: 180 Annotation: Subtype: Link Rect: 471, 637, 474, 626 ActionDest: 180 Annotation: Subtype: Link Rect: 344, 560, 351, 549 ActionDest: 262 Annotation: Subtype: Link Rect: 466, 461, 550, 450 Annotation: Subtype: Link Rect: 409, 428, 415, 417 ActionDest: 262 Annotation: Subtype: Link Rect: 537, 384, 544, 373 ActionDest: 262 Annotation: Subtype: Link Rect: 546, 384, 553, 373 ActionDest: 262 Annotation: Subtype: Link Rect: 340, 296, 347, 285 ActionDest: 262 Annotation: Subtype: Link Rect: 309, 285, 372, 274 Annotation: Subtype: Link Rect: 442, 230, 448, 219 ActionDest: 262 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 70, 395, 198, 384 Annotation: Subtype: Link Rect: 213, 131, 220, 120 ActionDest: 262 Annotation: Subtype: Link Rect: 62, 120, 68, 109 ActionDest: 262 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 529, 152, 553, 141 Annotation: Subtype: Link Rect: 306, 141, 380, 130 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 164, 287, 195, 276 ActionDest: 54 Annotation: Subtype: Link Rect: 68, 232, 98, 221 ActionDest: 54 Annotation: Subtype: Link Rect: 181, 199, 283, 188 Annotation: Subtype: Link Rect: 264, 188, 288, 177 Annotation: Subtype: Link Rect: 42, 177, 120, 166 Annotation: Subtype: Link Rect: 162, 144, 225, 133 ActionDest: 64 Annotation: Subtype: Link Rect: 232, 144, 288, 133 Annotation: Subtype: Link Rect: 42, 133, 90, 122 Annotation: Subtype: Link Rect: 380, 263, 406, 252 ActionDest: 104 Annotation: Subtype: Link Rect: 309, 205, 336, 194 ActionDest: 104 Annotation: Subtype: Link Rect: 429, 124, 455, 113 ActionDest: 113 Annotation: Subtype: Link Rect: 529, 112, 553, 101 Annotation: Subtype: Link Rect: 306, 101, 378, 90 Annotation: Subtype: Link Rect: 315, 77, 416, 67 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 77, 54, 103, 43 ActionDest: 113 Annotation: Subtype: Link Rect: 449, 210, 543, 199 Annotation: Subtype: Link Rect: 431, 177, 547, 166 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 136, 109, 142, 98 ActionDest: 262 Annotation: Subtype: Link Rect: 132, 65, 135, 54 ActionDest: 180 Annotation: Subtype: Link Rect: 379, 197, 394, 186 ActionDest: 262 Annotation: Subtype: Link Rect: 467, 197, 474, 186 ActionDest: 262 Annotation: Subtype: Link Rect: 422, 120, 438, 109 ActionDest: 262 Annotation: Subtype: Link Rect: 420, 54, 426, 43 ActionDest: 262 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 212, 747, 218, 736 ActionDest: 262 Annotation: Subtype: Link Rect: 224, 560, 230, 549 ActionDest: 262 Annotation: Subtype: Link Rect: 265, 450, 272, 439 ActionDest: 262 Annotation: Subtype: Link Rect: 205, 428, 228, 417 ActionDest: 262 Annotation: Subtype: Link Rect: 172, 373, 179, 362 ActionDest: 262 Annotation: Subtype: Link Rect: 243, 285, 249, 274 ActionDest: 262 Annotation: Subtype: Link Rect: 281, 208, 288, 197 ActionDest: 262 Annotation: Subtype: Link Rect: 144, 109, 151, 98 ActionDest: 262 Annotation: Subtype: Link Rect: 398, 736, 406, 725 ActionDest: 262 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 88, 242, 127, 232 Annotation: Subtype: Link Rect: 187, 242, 223, 232 Annotation: Subtype: Link Rect: 76, 231, 129, 222 Annotation: Subtype: Link Rect: 179, 231, 224, 222 Annotation: Subtype: Link Rect: 42, 221, 68, 212 Annotation: Subtype: Link Rect: 126, 221, 158, 212 Annotation: Subtype: Link Rect: 209, 221, 259, 212 Annotation: Subtype: Link Rect: 80, 211, 121, 202 Annotation: Subtype: Link Rect: 159, 211, 198, 202 Annotation: Subtype: Link Rect: 246, 211, 283, 202 Annotation: Subtype: Link Rect: 42, 201, 51, 192 Annotation: Subtype: Link Rect: 98, 201, 132, 192 Annotation: Subtype: Link Rect: 182, 201, 217, 192 Annotation: Subtype: Link Rect: 84, 191, 114, 182 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 376, 476, 511, 466 Annotation: Subtype: Link Rect: 347, 450, 461, 440 Annotation: Subtype: Link Rect: 346, 441, 461, 431 Annotation: Subtype: Link Rect: 339, 432, 454, 422 Annotation: Subtype: Link Rect: 353, 423, 468, 413 Annotation: Subtype: Link Rect: 378, 414, 492, 404 Annotation: Subtype: Link Rect: 363, 405, 478, 395 Annotation: Subtype: Link Rect: 360, 396, 474, 386 Annotation: Subtype: Link Rect: 349, 387, 463, 377 Annotation: Subtype: Link Rect: 345, 378, 459, 368 Annotation: Subtype: Link Rect: 352, 369, 467, 359 Annotation: Subtype: Link Rect: 356, 360, 470, 350 Annotation: Subtype: Link Rect: 361, 351, 475, 341 Annotation: Subtype: Link Rect: 345, 342, 459, 332 Annotation: Subtype: Link Rect: 336, 333, 450, 323 Annotation: Subtype: Link Rect: 364, 324, 478, 314 Annotation: Subtype: Link Rect: 370, 315, 485, 305 Annotation: Subtype: Link Rect: 342, 306, 457, 296 Annotation: Subtype: Link Rect: 355, 297, 469, 287 Annotation: Subtype: Link Rect: 346, 288, 460, 278 Annotation: Subtype: Link Rect: 357, 279, 471, 269 Annotation: Subtype: Link Rect: 360, 270, 474, 260 Annotation: Subtype: Link Rect: 354, 261, 468, 251 Annotation: Subtype: Link Rect: 364, 252, 479, 242 Annotation: Subtype: Link Rect: 353, 243, 468, 233 Annotation: Subtype: Link Rect: 361, 234, 476, 224 Annotation: Subtype: Link Rect: 380, 225, 494, 215 Annotation: Subtype: Link Rect: 362, 216, 476, 206 Annotation: Subtype: Link Rect: 340, 207, 454, 197 Annotation: Subtype: Link Rect: 351, 198, 465, 188 Annotation: Subtype: Link Rect: 341, 189, 455, 179 Annotation: Subtype: Link Rect: 350, 180, 464, 170 Annotation: Subtype: Link Rect: 353, 171, 467, 161 Annotation: Subtype: Link Rect: 424, 124, 471, 116 Annotation: Subtype: Link Rect: 427, 115, 463, 107 Annotation: Subtype: Link Rect: 468, 97, 478, 89 Annotation: Subtype: Link Rect: 473, 79, 483, 71 Annotation: Subtype: Link Rect: 380, 52, 427, 44 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 54, 728, 119, 720 Annotation: Subtype: Link Rect: 54, 710, 88, 702 Annotation: Subtype: Link Rect: 201, 692, 274, 684 Annotation: Subtype: Link Rect: 110, 656, 139, 648 Annotation: Subtype: Link Rect: 76, 638, 86, 630 Annotation: Subtype: Link Rect: 254, 620, 276, 612 Annotation: Subtype: Link Rect: 54, 611, 96, 603 Annotation: Subtype: Link Rect: 158, 593, 205, 585 Annotation: Subtype: Link Rect: 203, 575, 213, 567 Annotation: Subtype: Link Rect: 131, 557, 164, 549 Annotation: Subtype: Link Rect: 211, 548, 257, 540 Annotation: Subtype: Link Rect: 221, 521, 254, 513 Annotation: Subtype: Link Rect: 230, 494, 264, 486 Annotation: Subtype: Link Rect: 235, 467, 251, 459 Annotation: Subtype: Link Rect: 200, 449, 287, 441 Annotation: Subtype: Link Rect: 54, 440, 284, 432 Annotation: Subtype: Link Rect: 54, 431, 63, 423 Annotation: Subtype: Link Rect: 135, 404, 179, 396 Annotation: Subtype: Link Rect: 215, 386, 248, 378 Annotation: Subtype: Link Rect: 166, 359, 221, 351 Annotation: Subtype: Link Rect: 479, 728, 489, 720 Annotation: Subtype: Link Rect: 429, 692, 458, 684 Annotation: Subtype: Link Rect: 377, 647, 429, 639 Annotation: Subtype: Link Rect: 319, 620, 352, 612 Annotation: Subtype: Link Rect: 450, 602, 519, 594 Annotation: Subtype: Link Rect: 346, 566, 411, 558 Annotation: Subtype: Link Rect: 346, 548, 386, 540 Annotation: Subtype: Link Rect: 475, 494, 527, 486 Annotation: Subtype: Link Rect: 424, 458, 482, 450 Annotation: Subtype: Link Rect: 319, 431, 391, 423 Annotation: Subtype: Link Rect: 391, 395, 401, 387 Annotation: Subtype: Link Rect: 525, 368, 535, 360 Checksum: b3316315 Type: CRC32 Checksum: f98a936f627abda5b356f011ac435a98 Type: MD5 Checksum: 6283e9ccffeb5fa672cc323f06e530f9d53ee57c Type: SHA-1 Checksum: 29892ea1667381fa3e433bf7955fd235cc49d83f0c651a29439016ba5bb2c5f3 Type: SHA-256