563747d45e4206b42e238ce5165e732e 305827.pdf 203e8586a1ec4dab49c17be6220012955716f614 305827.pdf a0738772084b6e8b66c4b70a63c54259b784de26e83a56abb6f4ef61842dbe33 305827.pdf Title: Survival Outcomes in Sinonasal Mucosal Melanoma: Systematic Review and Meta-Analysis Subject: Background/Objectives: Sinonasal mucosal melanomas (SNMMs) are rare and aggressive malignancies with poor survival outcomes. Our systematic review and meta-analysis aim to evaluate overall survival (OS) rates in patients with SNMM; Methods: We conducted a systematic search, following PRISMA guidelines across PubMed, Web of Science (WOS), and citation searching for studies reporting survival and prognosis outcomes for SNMMs. Inclusion criteria included studies with 5-year OS rates. Studies were excluded if they included tumor sites other than the paranasal sinuses or nasal cavity, were published in languages other than English and Spanish, or had a sample size of fewer than 15 patients. Two reviewers independently screened studies, extracted data, and assessed study quality using the Joanna Briggs Institute (JBI) critical appraisal checklist. Analyses of survival probabilities were conducted. Meta-analyses were performed using a random-effects model. PROSPERO ID CRD42024565137; Results: A total of 515 articles were identified after removing duplicates, and 99 reports were assessed for eligibility. Of these, 35 studies were included in the meta-analysis, encompassing a total of 2383 SNMM patients, of whom 1192 (50%) were female, with a weighted mean age of 65.4 years (SD = 5.4). Fifteen studies were from Europe (42.9%), six (17.1%) were from America, eleven (31.4%) were from Asia, two (5.7%) were from Australia, and one (2.9%) combined European, United Kingdom, and American populations. The 5-year OS was 34.8 [95% CI = 30.6–39.5], with the highest OS in America at 40.5 [95% CI = 34.1–48.1], followed by Europe at 36.6 [95% CI = 30.6–43.7], Australia at 32.3 [95% CI = 12.5–83.8], and Asia at 28.1 [95% CI = 19.5–40.7]. The age-standardized incidence rate (ASIR) for SNMM ranges was between 0.07 and 0.14 per 100,000 persons/year, with a slightly higher incidence in women than in men; Conclusions: This meta-analysis, one of the largest to date on SNMM, confirms the aggressive nature of this melanoma subtype with poor survival outcomes. Despite geographic differences in survival rates, the overall 5-year survival remains low, highlighting the urgent need for improved treatment strategies and more research to improve patient outcomes. Keywords: sinonasal mucosal melanoma; survival; prognosis; overall survival Author: María Jesús Rojas-Lechuga, Sara Jubés, Manuel Molina-García, Rui Milton Patricio da Silva-Júnior, Claudio Sampieri, Cristóbal Langdon, Juan Ramón Gras-Cabrerizo, Manuel Bernal-Sprekelsen, Susana Puig and Isam Alobid Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Thu Nov 28 10:12:22 2024 CET ModDate: Thu Nov 28 10:25:06 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2338606 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DIMMOC+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 BJFQQF+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 PODIDO+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 IHOZOR+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 AWHDWW+VnURWPalladioL Type 1 Custom yes yes yes 32 0 JAXHOM+EURM10 Type 1 Builtin yes yes yes 68 0 JPNNDO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 80 0 JPNNEA+PalatinoLinotype TrueType WinAnsi yes yes no 83 0 JPNNEC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 86 0 JPNOPK+TimesNewRoman CID TrueType Identity-H yes yes yes 89 0 JPNNDO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 107 0 JPNNEA+PalatinoLinotype TrueType WinAnsi yes yes no 110 0 JPNNEC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 113 0 FXXUVH+CMSY10 Type 1 Builtin yes yes yes 120 0 JPNNDO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 132 0 JPNNDP+PalatinoLinotype CID TrueType Identity-H yes yes yes 135 0 JPNNEA+PalatinoLinotype TrueType WinAnsi yes yes no 141 0 JPNNEC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 144 0 JPNNDO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 170 0 JPNNDP+PalatinoLinotype CID TrueType Identity-H yes yes yes 173 0 JPNNEA+PalatinoLinotype TrueType WinAnsi yes yes no 179 0 JPNNEC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 182 0 JPNNDO+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 198 0 JPNNEA+PalatinoLinotype TrueType WinAnsi yes yes no 201 0 JPNNEC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 204 0 JPNOPK+TimesNewRoman CID TrueType Identity-H yes yes yes 207 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-04-11 02:42:46 CEST RepresentationInformation: 305827.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-04-10 13:55:25 CEST Size: 2338606 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 628 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Eligibility Criteria Destination: subsection.2.1 Item: Title: Information Sources Destination: subsection.2.2 Item: Title: Study Selection Destination: subsection.2.3 Item: Title: Data Collection Process Destination: subsection.2.4 Item: Title: Risk of Bias in Individual Studies and Pooled Evidence Destination: subsection.2.5 Item: Title: Summary Measures, Synthesis of Results, and Additional Analyses Destination: subsection.2.6 Item: Title: Risk of Bias Across Studies Destination: subsection.2.7 Item: Title: SNMM Incidence Rate Destination: subsection.2.8 Item: Title: Data Synthesis and Statistical Analysis Destination: subsection.2.9 Item: Title: Results Destination: section.3 Children: Item: Title: Literature Search Results Destination: subsection.3.1 Item: Title: Methodological Quality and Risk of Bias of Included Studies Destination: subsection.3.2 Item: Title: Publication Bias Destination: subsection.3.3 Item: Title: Patients’ Characteristics Destination: subsection.3.4 Item: Title: Overall Survival Destination: subsection.3.5 Item: Title: Histopathologic, Genetic Mutations and Biomarkers in SNMM Destination: subsection.3.6 Item: Title: Incidence Destination: subsection.3.7 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: appendix.A. Info: Title: Survival Outcomes in Sinonasal Mucosal Melanoma: Systematic Review and Meta-Analysis Author: María Jesús Rojas-Lechuga, Sara Jubés, Manuel Molina-García, Rui Milton Patricio da Silva-Júnior, Claudio Sampieri, Cristóbal Langdon, Juan Ramón Gras-Cabrerizo, Manuel Bernal-Sprekelsen, Susana Puig and Isam Alobid Subject: Background/Objectives: Sinonasal mucosal melanomas (SNMMs) are rare and aggressive malignancies with poor survival outcomes. Our systematic review and meta-analysis aim to evaluate overall survival (OS) rates in patients with SNMM; Methods: We conducted a systematic search, following PRISMA guidelines across PubMed, Web of Science (WOS), and citation searching for studies reporting survival and prognosis outcomes for SNMMs. Inclusion criteria included studies with 5-year OS rates. Studies were excluded if they included tumor sites other than the paranasal sinuses or nasal cavity, were published in languages other than English and Spanish, or had a sample size of fewer than 15 patients. Two reviewers independently screened studies, extracted data, and assessed study quality using the Joanna Briggs Institute (JBI) critical appraisal checklist. Analyses of survival probabilities were conducted. Meta-analyses were performed using a random-effects model. PROSPERO ID CRD42024565137; Results: A total of 515 articles were identified after removing duplicates, and 99 reports were assessed for eligibility. Of these, 35 studies were included in the meta-analysis, encompassing a total of 2383 SNMM patients, of whom 1192 (50%) were female, with a weighted mean age of 65.4 years (SD = 5.4). Fifteen studies were from Europe (42.9%), six (17.1%) were from America, eleven (31.4%) were from Asia, two (5.7%) were from Australia, and one (2.9%) combined European, United Kingdom, and American populations. The 5-year OS was 34.8 [95% CI = 30.6 39.5], with the highest OS in America at 40.5 [95% CI = 34.1 48.1], followed by Europe at 36.6 [95% CI = 30.6 43.7], Australia at 32.3 [95% CI = 12.5 83.8], and Asia at 28.1 [95% CI = 19.5 40.7]. The age-standardized incidence rate (ASIR) for SNMM ranges was between 0.07 and 0.14 per 100,000 persons/year, with a slightly higher incidence in women than in men; Conclusions: This meta-analysis, one of the largest to date on SNMM, confirms the aggressive nature of this melanoma subtype with poor survival outcomes. Despite geographic differences in survival rates, the overall 5-year survival remains low, highlighting the urgent need for improved treatment strategies and more research to improve patient outcomes. 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203e8586a1ec4dab49c17be6220012955716f614 Type: SHA-1 Checksum: a0738772084b6e8b66c4b70a63c54259b784de26e83a56abb6f4ef61842dbe33 Type: SHA-256