5448ac9165688c09cbd6e78784196ef5 305877.pdf 65d33aa3f633eb5495e3440694b4ce9312b97c08 305877.pdf 3b76b77609a22056288d206817b9cac547eaffc1cfe39417415204c16124b85b 305877.pdf Title: Age of Alzheimer's disease diagnosis in people with Down syndrome and associated factors: Results from the Horizon 21 European Down syndrome consortium Subject: Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Sat May 11 09:58:33 2024 CEST ModDate: Sat May 11 09:58:56 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 291244 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NCINIJ+Lato-Regular Type 1C WinAnsi yes yes no 370 0 NCINOH+Lato-Bold Type 1C WinAnsi yes yes no 373 0 NCIOMD+Lato-Italic Type 1C WinAnsi yes yes no 376 0 NCIPDB+STIXTwoMath Type 1C Custom yes yes yes 95 0 NCIPDC+STIXTwoText-Italic Type 1C Custom yes yes yes 100 0 NCIPMA+Lato-Black Type 1C WinAnsi yes yes no 105 0 NCJAIM+Lato-BoldItalic Type 1C WinAnsi yes yes no 108 0 NCJBHI+STIXTwoText-BoldItalic Type 1C Custom yes yes yes 44 0 NCJCGD+STIX-Regular Type 1C WinAnsi yes yes no 74 0 NCJDIN+STIXTwoText Type 1C Custom yes yes yes 84 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-11 02:50:39 CET RepresentationInformation: 305877.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-10 13:44:51 CET Size: 291244 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'alz13779-supitem-0001' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz13779-supitem-0001' cannot be found ID: PDF-HUL-122 Offset: 268856 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 445 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Age of Alzheimer’s disease diagnosis in people with Down syndrome and associated factors: Results from the Horizon 21 European Down syndrome consortium Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | BACKGROUND Destination: section..1.1 Item: Title: 2 | METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Participants Destination: subsection..1.2.1 Item: Title: 2.2 | Data collection and measurements Destination: subsection..1.2.2 Children: Item: Title: 2.2.1 | Alzheimer’s disease (AD) diagnosis Destination: subsubsection..1.2.2.1 Item: Title: 2.2.2 | Clinical co-occurring conditions Destination: subsubsection..1.2.2.2 Item: Title: 2.2.3 | Apolipoprotein E status Destination: subsubsection..1.2.2.3 Item: Title: 2.3 | Statistical analysis Destination: subsection..1.2.3 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | AD status Destination: subsection..1.3.1 Item: Title: 3.2 | Co-occurring conditions and APOE status Destination: subsection..1.3.2 Item: Title: 3.3 | Factors associated with age of AD diagnosis Destination: subsection..1.3.3 Item: Title: 4 | DISCUSSION Destination: section..1.4 Children: Item: Title: 4.1 | Co-occurring conditions and association with AD Destination: subsection..1.4.1 Item: Title: 4.2 | Sex differences and association with AD Destination: subsection..1.4.2 Item: Title: 4.3 | APOE and association with AD Destination: subsection..1.4.3 Item: Title: 4.4 | Sleep problems and association with AD Destination: subsection..1.4.4 Item: Title: 4.5 | Mental health problems and association with AD Destination: subsection..1.4.5 Item: Title: 4.6 | Level of intellectual disabilities and association with AD Destination: subsection..1.4.6 Item: Title: 4.7 | Limitations Destination: subsection..1.4.7 Item: Title: 5 | CONCLUSIONS Destination: section..1.5 Item: Title: AUTHOR CONTRIBUTION Destination: section*.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.6 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.8 Item: Title: CONSENT STATEMENT Destination: section*.10 Item: Title: ORCID Destination: section*.12 Item: Title: REFERENCES Destination: section*.14 Item: Title: SUPPORTING INFORMATION Destination: section*.16 Info: Title: Age of Alzheimer's disease diagnosis in people with Down syndrome and associated factors: Results from the Horizon 21 European Down syndrome consortium Author: Subject: Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Sat May 11 10:28:33 CEST 2024 ModDate: Sat May 11 10:28:56 CEST 2024 ID: 0xd02e72be959764ed2d637df30421d153, 0x64dedc7e197094d1d3974eb0d6d0d55d Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: NCINIJ+Lato-Regular FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: NCINIJ+Lato-Regular Flags: Nonsymbolic FontBBox: -94, -183, 1117, 919 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NCIPDC+STIXTwoText-Italic FontSubset: true FirstChar: 2 LastChar: 4 FontDescriptor: FontName: NCIPDC+STIXTwoText-Italic Flags: Symbolic, Italic FontBBox: -893, -367, 1298, 1047 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NCJDIN+STIXTwoText FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: NCJDIN+STIXTwoText Flags: Symbolic FontBBox: -948, -373, 1297, 1047 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NCINOH+Lato-Bold FontSubset: true FirstChar: 37 LastChar: 151 FontDescriptor: FontName: NCINOH+Lato-Bold Flags: Nonsymbolic, ForceBold FontBBox: -89, -181, 1143, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NCIOMD+Lato-Italic FontSubset: true FirstChar: 38 LastChar: 146 FontDescriptor: FontName: NCIOMD+Lato-Italic Flags: Nonsymbolic, Italic FontBBox: -115, -250, 1024, 919 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NCIPMA+Lato-Black FontSubset: true FirstChar: 49 LastChar: 88 FontDescriptor: FontName: NCIPMA+Lato-Black Flags: Nonsymbolic, ForceBold FontBBox: -83, -179, 1167, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NCJCGD+STIX-Regular FontSubset: true FirstChar: 95 LastChar: 95 FontDescriptor: FontName: NCJCGD+STIX-Regular Flags: Nonsymbolic FontBBox: 0, -125, 500, -74 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NCJAIM+Lato-BoldItalic FontSubset: true FirstChar: 45 LastChar: 112 FontDescriptor: FontName: NCJAIM+Lato-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -110, -250, 1049, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NCJBHI+STIXTwoText-BoldItalic FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: NCJBHI+STIXTwoText-BoldItalic Flags: Symbolic, Italic FontBBox: -893, -427, 1451, 1047 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NCIPDB+STIXTwoMath FontSubset: true FirstChar: 2 LastChar: 62 FontDescriptor: FontName: NCIPDB+STIXTwoMath Flags: Symbolic FontBBox: 56, -25, 658, 547 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: 2024-05-11T13:28:33+05:30 2024-05-11T13:28:56+05:30 2024-05-11T13:28:56+05:30 LaTeX with hyperref package Acrobat Distiller 10.0.0 (Windows) 10.1002/alz.13779 10.1002/(ISSN)1552-5279 3 VoR 10.1002/alz.13779 application/pdf Age of Alzheimer's disease diagnosis in people with Down syndrome and associated factors: Results from the Horizon 21 European Down syndrome consortium uuid:69caa05a-b2e7-3c1d-9f23-e25e71d5bcc4 uuid:ba75c6d6-05f1-4313-988b-8dd0985a3808 Pages: Page: Label: 3270 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 170, 578, 176, 586 Destination: 359 Annotation: Subtype: Link Rect: 176, 578, 183, 586 Destination: 359 Annotation: Subtype: Link Rect: 184, 574, 195, 585 Annotation: Subtype: Link Rect: 298, 578, 304, 586 Destination: 359 Annotation: Subtype: Link Rect: 305, 578, 311, 586 Destination: 359 Annotation: Subtype: Link Rect: 312, 574, 323, 585 Annotation: Subtype: Link Rect: 449, 578, 456, 586 Destination: 359 Annotation: Subtype: Link Rect: 456, 578, 463, 586 Destination: 359 Annotation: Subtype: Link Rect: 166, 560, 173, 568 Destination: 359 Annotation: Subtype: Link Rect: 173, 560, 180, 568 Destination: 359 Annotation: Subtype: Link Rect: 283, 560, 290, 568 Destination: 359 Annotation: Subtype: Link Rect: 442, 560, 448, 568 Destination: 359 Annotation: Subtype: Link Rect: 449, 560, 460, 568 Destination: 359 Annotation: Subtype: Link Rect: 129, 542, 136, 550 Destination: 359 Annotation: Subtype: Link Rect: 245, 542, 256, 550 Destination: 359 Annotation: Subtype: Link Rect: 377, 542, 389, 550 Destination: 359 Annotation: Subtype: Link Rect: 474, 542, 481, 550 Destination: 359 Annotation: Subtype: Link Rect: 481, 542, 492, 550 Destination: 359 Annotation: Subtype: Link Rect: 493, 542, 504, 550 Destination: 359 Annotation: Subtype: Link Rect: 125, 524, 136, 532 Destination: 359 Annotation: Subtype: Link Rect: 137, 524, 148, 532 Destination: 359 Annotation: Subtype: Link Rect: 148, 524, 159, 532 Destination: 359 Annotation: Subtype: Link Rect: 265, 524, 277, 532 Destination: 359 Annotation: Subtype: Link Rect: 277, 524, 288, 532 Destination: 359 Annotation: Subtype: Link Rect: 368, 524, 380, 532 Destination: 359 Annotation: Subtype: Link Rect: 516, 524, 527, 532 Destination: 359 Annotation: Subtype: Link Rect: 119, 507, 126, 514 Destination: 359 Annotation: Subtype: Link Rect: 126, 506, 138, 514 Destination: 359 Annotation: Subtype: Link Rect: 244, 506, 251, 514 Destination: 359 Annotation: Subtype: Link Rect: 251, 507, 258, 514 Destination: 359 Annotation: Subtype: Link Rect: 258, 506, 269, 514 Destination: 359 Annotation: Subtype: Link Rect: 64, 149, 164, 158 Annotation: Subtype: Link Rect: 210, 72, 393, 79 Annotation: Subtype: Link Rect: 78, 29, 183, 37 Thumb: true Page: Label: 3271 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 113, 283, 123, 290 Destination: 72 Annotation: Subtype: Link Rect: 106, 232, 112, 239 Destination: 82 Annotation: Subtype: Link Rect: 283, 232, 288, 239 Destination: 82 Annotation: Subtype: Link Rect: 157, 206, 172, 213 Destination: 82 Annotation: Subtype: Link Rect: 82, 193, 87, 200 Destination: 82 Annotation: Subtype: Link Rect: 216, 167, 231, 174 Destination: 82 Annotation: Subtype: Link Rect: 226, 129, 235, 135 Destination: 82 Annotation: Subtype: Link Rect: 85, 116, 94, 122 Destination: 82 Annotation: Subtype: Link Rect: 180, 90, 189, 96 Destination: 82 Annotation: Subtype: Link Rect: 521, 336, 540, 342 Destination: 82 Annotation: Subtype: Link Rect: 452, 310, 458, 316 Destination: 82 Annotation: Subtype: Link Rect: 510, 257, 527, 264 Destination: 82 Annotation: Subtype: Link Rect: 409, 193, 428, 200 Destination: 82 Annotation: Subtype: Link Rect: 347, 167, 356, 174 Destination: 82 Annotation: Subtype: Link Rect: 377, 154, 402, 161 Destination: 82 Annotation: Subtype: Link Rect: 539, 116, 547, 122 Destination: 82 Thumb: true Page: Label: 3272 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 156, 729, 175, 735 Destination: 82 Annotation: Subtype: Link Rect: 126, 560, 140, 567 Destination: 82 Annotation: Subtype: Link Rect: 180, 483, 185, 489 Destination: 82 Annotation: Subtype: Link Rect: 263, 185, 272, 191 Destination: 82 Annotation: Subtype: Link Rect: 525, 392, 534, 398 Destination: 82 Thumb: true Page: Label: 3273 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 108, 130, 115, 138 Destination: 31 Annotation: Subtype: Link Rect: 335, 431, 343, 437 Destination: 82 Annotation: Subtype: Link Rect: 419, 337, 426, 345 Destination: 31 Thumb: true Page: Label: 3274 Sequence: 5 Thumb: true Page: Label: 3275 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 64, 441, 70, 449 Destination: 42 Annotation: Subtype: Link Rect: 383, 512, 389, 519 Destination: 82 Annotation: Subtype: Link Rect: 375, 224, 384, 231 Destination: 82 Annotation: Subtype: Link Rect: 365, 199, 374, 205 Destination: 82 Annotation: Subtype: Link Rect: 339, 172, 356, 179 Destination: 82 Annotation: Subtype: Link Rect: 360, 147, 369, 153 Destination: 82 Annotation: Subtype: Link Rect: 366, 121, 375, 127 Destination: 82 Thumb: true Page: Label: 3276 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 73, 236, 78, 242 Destination: 42 Annotation: Subtype: Link Rect: 73, 371, 78, 380 Destination: 42 Annotation: Subtype: Link Rect: 73, 506, 78, 517 Destination: 42 Annotation: Subtype: Link Rect: 73, 641, 78, 655 Destination: 42 Thumb: true Page: Label: 3277 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 164, 676, 173, 682 Destination: 82 Annotation: Subtype: Link Rect: 279, 637, 288, 643 Destination: 82 Annotation: Subtype: Link Rect: 130, 611, 139, 617 Destination: 82 Annotation: Subtype: Link Rect: 241, 611, 250, 617 Destination: 82 Annotation: Subtype: Link Rect: 147, 598, 156, 604 Destination: 82 Annotation: Subtype: Link Rect: 279, 598, 288, 604 Destination: 82 Annotation: Subtype: Link Rect: 56, 437, 75, 443 Destination: 82 Annotation: Subtype: Link Rect: 230, 424, 239, 430 Destination: 92 Annotation: Subtype: Link Rect: 177, 333, 186, 339 Destination: 92 Annotation: Subtype: Link Rect: 279, 333, 288, 339 Destination: 92 Annotation: Subtype: Link Rect: 355, 690, 360, 696 Destination: 82 Annotation: Subtype: Link Rect: 394, 651, 403, 657 Destination: 92 Annotation: Subtype: Link Rect: 351, 504, 360, 511 Destination: 92 Annotation: Subtype: Link Rect: 375, 453, 384, 459 Destination: 92 Annotation: Subtype: Link Rect: 407, 440, 416, 446 Destination: 92 Annotation: Subtype: Link Rect: 516, 426, 533, 433 Destination: 92 Annotation: Subtype: Link Rect: 388, 348, 420, 355 Destination: 82 Thumb: true Page: Label: 3278 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 412, 232, 495, 241 Destination: null Annotation: Subtype: Link Rect: 382, 139, 393, 141 Annotation: Subtype: Link Rect: 392, 138, 537, 146 Annotation: Subtype: Link Rect: 355, 126, 366, 128 Annotation: Subtype: Link Rect: 366, 125, 511, 133 Thumb: true Page: Label: 3279 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 111, 526, 229, 534 Annotation: Subtype: Link Rect: 73, 129, 175, 136 Annotation: Subtype: Link Rect: 363, 464, 453, 471 Thumb: true Page: Label: 3280 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 395, 482, 517, 489 Thumb: true Checksum: df364016 Type: CRC32 Checksum: 5448ac9165688c09cbd6e78784196ef5 Type: MD5 Checksum: 65d33aa3f633eb5495e3440694b4ce9312b97c08 Type: SHA-1 Checksum: 3b76b77609a22056288d206817b9cac547eaffc1cfe39417415204c16124b85b Type: SHA-256