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Swift Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Mar 27 11:29:02 2024 CET ModDate: Thu Mar 28 04:13:33 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 2367543 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 35 0 MyriadPro-Bold Type 1C Custom yes no yes 42 0 MyriadPro-It Type 1C Custom yes no yes 37 0 MyriadPro-Regular2 Type 1C WinAnsi yes no no 360 0 MyriadPro-Light Type 1C Custom yes no yes 36 0 MyriadPro-LightIt Type 1C WinAnsi yes no yes 39 0 MyriadPro-Semibold Type 1C Custom yes no yes 40 0 WarnockPro-It Type 1C WinAnsi yes no yes 38 0 WarnockPro-Regular Type 1C Custom yes no yes 41 0 BXCUMB+STIX-Regular Type 1C WinAnsi yes yes yes 69 0 MyriadPro-Regular3 Type 1C WinAnsi yes no yes 319 0 MyriadPro-SemiboldIt Type 1C WinAnsi yes no yes 102 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-01-31 02:46:45 CET RepresentationInformation: 305882.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-01-30 19:27:24 CET Size: 2367543 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 444 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors Children: Item: Title: Abstract Children: Item: Title: Background Item: Title: Methods Item: Title: Results Item: Title: Conclusions Item: Title: Introduction Item: Title: Methods and demographics Children: Item: Title: Data acquisition Item: Title: Statistics Item: Title: Results Children: Item: Title: PGRN concentrations in people with GRN variants Item: Title: Plasma Item: Title: Serum Item: Title: CSF (Fig. 2B) Item: Title: PGRN concentrations by clinical phenotype Children: Item: Title: Neurodegenerative disorders Item: Title: PGRN concentration differences by sex Item: Title: PGRN concentration with increasing age Item: Title: PGRN concentration by weight Item: Title: PGRN concentration in relation to the GRN rs5848 and TMEM106b rs1990622 polymorphisms Item: Title: Discussion Item: Title: Acknowledgements Item: Title: References Info: Title: A systematic review of progranulin concentrations in biofluids in over 7,000 people assessing the pathogenicity of Author: Imogen J. Swift Subject: Alzheimer's Research & Therapy, https://doi.org/10.1186/s13195-024-01420-z Keywords: Frontotemporal dementia;Progranulin Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Wed Mar 27 11:29:02 CET 2024 ModDate: Thu Mar 28 04:13:33 CET 2024 ID: 0x493dda7513ed279ad8ca574680bef9ac, 0x3961c75f78d8b2e71b0f648604e5ee99 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 115 ImageHeight: 119 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1946 ImageHeight: 2451 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1819 ImageHeight: 2481 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1946 ImageHeight: 2193 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -49, -250, 1046, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: BXCUMB+STIX-Regular FontSubset: true FirstChar: 32 LastChar: 61 FontDescriptor: FontName: BXCUMB+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: WarnockPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -221, -533, 1474, 950 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiboldIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldIt Flags: Nonsymbolic, Italic FontBBox: -193, -250, 1164, 972 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-LightIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-LightIt Flags: Nonsymbolic, Italic FontBBox: -121, -250, 1007, 863 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Regular2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular2 Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: 2024-03-27T10:29:02 Adobe InDesign 15.1 (Windows) 2024-03-28T04:13:33+01:00 2024-03-28T04:13:33+01:00 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) Frontotemporal dementia;Progranulin False application/pdf https://doi.org/10.1186/s13195-024-01420-z BioMed Central Alzheimer's Research & Therapy, https://doi.org/10.1186/s13195-024-01420-z Frontotemporal dementia Progranulin A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of Imogen J. Swift Rosa Rademakers NiCole Finch Matt Baker Roberta Ghidoni Luisa Benussi Giuliano Binetti Giacomina Rossi Matthis Synofzik Carlo Wilke David Mengel Caroline Graff Leonel T. Takada Raquel Sánchez-Valle Anna Antonell Daniela Galimberti Chiara Fenoglio Maria Serpente Marina Arcaro Stefanie Schreiber Stefan Vielhaber Philipp Arndt Isabel Santana Maria Rosario Almeida Fermín Moreno Myriam Barandiaran Alazne Gabilondo Johannes Stubert Estrella Gómez-Tortosa Pablo Agüero M. José Sainz Tomohito Gohda Maki Murakoshi Nozomu Kamei Sarah Kittel-Schneider Andreas Reif Johannes Weigl Jinlong Jian Chuanju Liu Ginette Serrero Thomas Greither Gerit Theil Ebba Lohmann Stefano Gazzina Silvia Bagnoli Giovanni Coppola Amalia Bruni Mirja Quante Wieland Kiess Andreas Hiemisch Anne Jurkutat Matthew S. Block Aaron M. Carlson Geir Bråthen Sigrid Botne Sando Gøril Rolfseng Grøntvedt Camilla Lauridsen Amanda Heslegrave Carolin Heller Emily Abel Alba Gómez-Núñez Roger Puey Andrea Arighi Enmanuela Rotondo Lize C. Jiskoot Lieke H. H. Meeter João Durães Marisa Lima Miguel Tábuas-Pereira João Lemos Bradley Boeve Ronald C. Petersen Dennis W. Dickson Neill R. Graff-Radford Isabelle LeBer Leila Sellami Foudil Lamari Fabienne Clot Barbara Borroni Valentina Cantoni Jasmine Rivolta Alberto Lleó Juan Fortea Daniel Alcolea Ignacio Illán-Gala Lucie Andres-Cerezo Philip Van Damme Jordi Clarimon Petra Steinacker Emily Feneberg Markus Otto Emma L. van der Ende John C. van Swieten Harro Seelaar Henrik Zetterberg Aitana Sogorb-Esteve Jonathan D. 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