994a9460b5e8b4f6cc33555c7d96b643 305883.pdf 9a45dd3030753b944e440abd5bee6fa622760aa9 305883.pdf d143b189c17c8f92d88d8b711d5857271590ced9353adc4a2609be46e41cd12d 305883.pdf Title: Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference Subject: DOI: 10.1093/europace/euae070; Europace, 26, 4, 2024-4-9.; Abstract: Aims: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results: Eighty-three international experts met in Münster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF. Conclusions: Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF. Keywords: Atrial fibrillation; Artificial intelligence; Biomarkers; Heart failure; Atrial cardiomyopathy; Cognitive function; Dementia; Outcomes; Quality of care; Cost; Research; Rhythm management; Catheter ablation; Anticoagulation; Bleeding; Research priorities; Technology; Stroke; Integrated care; Screening; AFNET; EHRA; Guidelines; Consensus statement Author: Dominik Linz Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64 Producer: PDFlib+PDI 9.0.7p3 (C++/Win64) CreationDate: Mon Apr 8 17:06:22 2024 CEST ModDate: Mon Apr 8 17:48:31 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 2548598 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NUXMRP+GillSansNova-Bold CID TrueType Identity-H yes 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2528277 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: OneColumn PageMode: UseOutlines Language: en Outlines: Item: Title: Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference Destination: head1 Children: Item: Title: Introduction Destination: seceuae070-s0 Item: Title: Methods Destination: seceuae070-s1 Item: Title: Active rhythm management: from symptom control to outcome reduction Destination: seceuae070-s1.1 Children: Item: Title: Identification of patients suitable for rhythm control Destination: seceuae070-s1.1.1 Item: Title: Role of atrial fibrillation ablation for delivering early rhythm control Destination: seceuae070-s1.1.2 Item: Title: Improving atrial fibrillation ablation Destination: seceuae070-s1.1.3 Item: Title: New antiarrhythmic drugs Destination: seceuae070-s1.1.4 Item: Title: Rate control drugs and ablate and pace Destination: seceuae070-s1.1.5 Children: Item: Title: Practical considerations and summary Destination: seceuae070-s1.1.5.1 Item: Title: Knowledge gaps and opportunities Destination: seceuae070-s1.1.5.2 Item: Title: Atrial fibrillation burden in patients with electrocardiogram-diagnosed atrial fibrillation and in patients with device-detected atrial fibrillation Destination: seceuae070-s1.2 Children: Item: Title: Device-detected atrial fibrillation and electrocardiogram-documented atrial fibrillation Destination: seceuae070-s1.2.1 Children: Item: Title: Practical considerations and summary Destination: seceuae070-s1.2.1.1 Item: Title: Knowledge gaps and hurdles Destination: seceuae070-s1.2.1.2 Item: Title: Improved stroke prevention Destination: seceuae070-s1.3 Children: Item: Title: Clinical risk factors Destination: seceuae070-s1.3.1 Item: Title: Genetic risk Destination: seceuae070-s1.3.2 Item: Title: Atrial fibrillation burden Destination: seceuae070-s1.3.3 Item: Title: Biomolecules Destination: seceuae070-s1.3.4 Item: Title: Imaging Destination: seceuae070-s1.3.5 Item: Title: Longitudinal reassessment of risk and adjustment of therapy Destination: seceuae070-s1.3.6 Children: Item: Title: Practical considerations and summary Destination: seceuae070-s1.3.6.1 Item: Title: Knowledge gaps and research opportunities Destination: seceuae070-s1.3.6.2 Item: Title: Risk factor and comorbidity management for secondary prevention of atrial fibrillation Destination: seceuae070-s1.4 Children: Item: Title: Practical considerations and summary Destination: seceuae070-s1.4.1 Children: Item: Title: Knowledge gaps and hurdles Destination: seceuae070-s1.4.2 Item: Title: Artificial intelligence in the detection and management of 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University Press Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference Dominik Linz Jason G. Andrade Elena Arbelo Giuseppe Boriani Guenter Breithardt A. John Camm Valeria Caso Jens Cosedis Nielsen Mirko De Melis Tom De Potter Wolfgang Dichtl Søren Zoega Diederichsen Dobromir Dobrev Nicolas Doll David Duncker Elke Dworatzek Lars Eckardt Christoph Eisert Larissa Fabritz Michal Farkowski David Filgueiras-Rama Andreas Goette Eduard Guasch Guido Hack Stéphane Hatem Karl Georg Haeusler Jeff S. Healey Hein Heidbuechel Ziad Hijazi Lucas H. Hofmeister Leif Hove-Madsen Thomas Huebner Stefan Kääb Dipak Kotecha Katarzyna Malaczynska-Rajpold José Luis Merino Andreas Metzner Lluís Mont Ghulam Andre Ng Michael Oeff Abdul Shokor Parwani Helmut Puererfellner Ursula Ravens Michiel Rienstra Prashanthan Sanders Daniel Scherr Renate Schnabel Ulrich Schotten Christian Sohns Gerhard Steinbeck Daniel Steven Tobias Toennis Stylianos Tzeis Isabelle C. van Gelder Roderick H. van Leerdam Kevin Vernooy Manish Wadhwa Reza Wakili Stephan Willems Henning Witt Stef Zeemering Paulus Kirchhof DOI: 10.1093/europace/euae070; Europace, 26, 4, 2024-4-9.; Abstract: Aims: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results: Eighty-three international experts met in Münster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF. Conclusions: Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF. © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. Atrial fibrillation Artificial intelligence Biomarkers Heart failure Atrial cardiomyopathy Cognitive function Dementia Outcomes Quality of care Cost Research Rhythm management Catheter ablation Anticoagulation Bleeding Research priorities Technology Stroke Integrated care Screening AFNET EHRA Guidelines Consensus statement Journal Europace © The Author(s) 2024. 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