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Keywords:        cestodes, Echinococcus granulosus, HLBP family, lipoprotein, antigen B, immunomodulation, macrophage
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     Item: 
      Title: Modulatory actions of Echinococcus granulosus antigen B on macrophage inflammatory activation
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        Title: 1 Introduction
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       Item: 
        Title: 2 Materials and methods
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         Item: 
          Title: 2.1 Parasite material
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         Item: 
          Title: 2.2 VHH/VHs library construction
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         Item: 
          Title: 2.3 Panning of the VHH/VHs library and screening of anti-EgAgB clones
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         Item: 
          Title: 2.4 Cloning of VHH/VHs DNAs coding sequences in a robust expression system
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          Title: 2.5 Sequencing of DNAs coding anti-EgAgB VHHs/VHs clones
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          Title: 2.6 EgAgB subunit recognition of anti-EgAgB VHHs/VHs clones
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          Title: 2.7 Expression of anti-EgAgB VHHs/VHs clones in BL21 E. coli cells
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          Title: 2.8 Preparation of anti-EgAgB immunoaffinity column
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          Title: 2.9 Purification of EgAgB from HF
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          Title: 2.10 Obtaining rEgAgB8/1 expressed in eukaryotic insect cells
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          Title: 2.11 Native and denaturing gel electrophoresis and western blot analysis
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         Item: 
          Title: 2.12 Lipid analysis
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         Item: 
          Title: 2.13 Dynamic light scattering
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         Item: 
          Title: 2.14 Mice
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          Title: 2.15 In vitro EgAgB effect on macrophage activation
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         Item: 
          Title: 2.16 In vivo EgAgB effect on mouse peritoneal cavity
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          Title: 2.17 Measurement of cell responses
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          Title: 2.18 Data analysis
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        Title: 3 Results
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          Title: 3.1 Development of a VHH specific for EgAgB8/1
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          Title: 3.2 Immunoaffinity with anti-EgAgB clone 1 allowed obtaining nEgAgB and rEgAgB8/1 preparations suitable for macrophage functional studies
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          Title: 3.3 nEgAgB and rEgAgB8/1 exhibited differences in size and lipid composition
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          Title: 3.4 Both nEgAgB and rEgAgB8/1 interfered with LPS-driven macrophage activation in vitro
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          Title: 3.5 Compared to nEgAgB, rEgAgB8/1 showed a modest modulation of LPS-induced cytokine secretion and macrophage activation in the peritoneum
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        Title: 4 Discussion
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        Title: Data availability statement
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       Item: 
        Title: Ethics statement
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       Item: 
        Title: Author contributions
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        Title: Funding
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       Item: 
        Title: Acknowledgments
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       Item: 
        Title: Conflict of interest
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       Item: 
        Title: Publisher’s note
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       Item: 
        Title: Supplementary material
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       Item: 
        Title: References
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    Keywords: cestodes, Echinococcus granulosus, HLBP family, lipoprotein, antigen B, immunomodulation, macrophage
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