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Study protocol Subject: International Journal of Bipolar Disorders, https://doi.org/10.1186/s40345-024-00337-8 Keywords: Bipolar disorder; Metabolic syndrome; Medical comorbidities; Quality of life; Precision medicine Author: Giovanni de Girolamo Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri May 3 12:59:17 2024 CEST ModDate: Sat May 4 12:50:08 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1084190 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 70 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 71 0 MyriadPro-It Type 1C Custom yes no yes 72 0 MyriadPro-Regular2 Type 1C WinAnsi yes no no 413 0 MyriadPro-Light Type 1C Custom yes no yes 73 0 MyriadPro-LightIt Type 1C WinAnsi yes no yes 414 0 MyriadPro-Semibold Type 1C Custom yes no yes 75 0 WarnockPro-Regular Type 1C Custom yes no yes 74 0 MyriadPro-SemiboldIt Type 1C Custom yes no yes 88 0 MyriadPro-Regular3 Type 1C WinAnsi yes no yes 308 0 WarnockPro-It Type 1C Custom yes no yes 109 0 YWFMOX+STIX-Regular Type 1C Custom yes yes yes 187 0 WarnockPro-Light Type 1C Custom yes no yes 192 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-01-24 02:42:45 CET RepresentationInformation: 306330.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-01-23 13:37:31 CET Size: 1084190 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 521 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Medical comorbidities in bipolar disorder (BIPCOM): clinical validation of risk factors and biomarkers to improve prevention and treatment. Study protocol Children: Item: Title: Abstract Children: Item: Title: Background Item: Title: Methods Item: Title: Discussion Item: Title: Background Item: Title: Methods Children: Item: Title: Aims Item: Title: The general architecture of the project Item: Title: Study design Children: Item: Title: Study 1: the registry study Item: Title: Study 2: the study of medical records Item: Title: Study 3: the Exploratory Clinical Study (ECS) Children: Item: Title: Participants Item: Title: Recruitment strategy Item: Title: Participant retention strategies in study 3 Item: Title: Clinical measures Item: Title: Biological measures Item: Title: Digital measures Item: Title: Data analyses Children: Item: Title: Data quality management Item: Title: Study 1: the registry study Item: Title: Study 2: the study of medical records Item: Title: Study 3: the exploratory clinical study Item: Title: Power and sample size Children: Item: Title: Study 1: the registry study Item: Title: Study 2: the study of medical records Item: Title: Study 3: the exploratory clinical study Item: Title: Discussion Children: Item: Title: The final output of the project: the clinical support tool Item: Title: Patient and public involvement: the qualitative study and focus groups Item: Title: Data transfer Item: Title: Data storage Item: Title: Data access and quality assurance Item: Title: Strength and limitations of the proposal Item: Title: Conclusions Item: Title: Acknowledgements Item: Title: References Info: Title: Medical comorbidities in bipolar disorder (BIPCOM): clinical validation of risk factors and biomarkers to improve prevention and treatment. Study protocol Author: Giovanni de Girolamo Subject: International Journal of Bipolar Disorders, https://doi.org/10.1186/s40345-024-00337-8 Keywords: Bipolar disorder; Metabolic syndrome; Medical comorbidities; Quality of life; Precision medicine Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri May 03 13:29:17 CEST 2024 ModDate: Sat May 04 12:50:08 CEST 2024 ID: 0xaf9650d6e55a209ffea02a36387cce41, 0x35621a05b0ffe786f97a0709dd327d30 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: WarnockPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Light Flags: Serif, Nonsymbolic FontBBox: -175, -515, 1437, 929 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-SemiboldIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldIt Flags: Nonsymbolic, Italic FontBBox: -193, -250, 1164, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -49, -250, 1046, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YWFMOX+STIX-Regular FontSubset: true FirstChar: 31 LastChar: 45 FontDescriptor: FontName: YWFMOX+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Regular2 FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular2 Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: WarnockPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -221, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-LightIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-LightIt Flags: Nonsymbolic, Italic FontBBox: -121, -250, 1007, 863 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true XMP: 2024-05-03T16:29:17+05:30 Springer 2024-05-04T12:50:08+02:00 2024-05-04T12:50:08+02:00 Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) Bipolar disorder; Metabolic syndrome; Medical comorbidities; Quality of life; Precision medicine False application/pdf https://doi.org/10.1186/s40345-024-00337-8 Springer Berlin Heidelberg International Journal of Bipolar Disorders, https://doi.org/10.1186/s40345-024-00337-8 Bipolar disorder Metabolic syndrome Medical comorbidities Quality of life Precision medicine Medical comorbidities in bipolar disorder (BIPCOM): clinical validation of risk factors and biomarkers to improve prevention and treatment. Study protocol Giovanni de Girolamo Ole A. Andreassen Michael Bauer Paolo Brambilla Stefano Calza Nicholas Citerà Rosa Corcoy Andrea Fagiolini Miguel Garcia-Argibay Ophélia Godin Florian Klingler Nene F. Kobayashi Henrik Larsson Marion Leboyer Silke Matura Alessandra Martinelli Víctor De la Peña-Arteaga Roberto Poli Andreas Reif Philipp Ritter Linn N. Rødevand Marta Magno Elisa Caselani Maximilian Bayas Frank Bellivier Narcís Cardoner Álvarez Pietro Carmellini Federico Cevoli Julia Clemens Philippe Courtet Lorena Consoli Giuseppe Delvecchio Maja Dobrosavljevic Bruno Etain Hendrik Friedrichsen Adrienne Kelemen Despoina Koukouna Eugenia Mato Dídac Mauricio Romina Miranda-Olivos Lisa Möbius Chiara Moltrasio Caroline Mohn-Haugen Isabelle Nuss Emilie Olie Agnes Pelletier Zillur Rahman Davide Rampi Jonathan Repple Eugenia Resmini Julia Schneider Elena Toffol 10.1186/s40345-024-00337-8 2010-04-23 true springer.com springerlink.com https://doi.org/10.1186/s40345-024-00337-8 10.1186/s40345-024-00337-8 2194-7511 journal International Journal of Bipolar Disorders The Author(s) 2010-04-23 true 10.1186/s40345-024-00337-8 noindex springer.com springerlink.com VoR uuid:d5d9b764-abf2-489b-9057-e400ae68533c uuid:9560819f-d831-43a3-a733-e46ac4d0353e default 1 converted uuid:d5d9b764-abf2-489b-9057-e400ae68533c converted to PDF/A-2b pdfToolbox 2024-05-03T16:30:27+05:30 converted uuid:cac1a1f7-35ae-4cfe-8598-549d1347b07b converted to PDF/A-2b pdfToolbox 2024-05-03T16:30:56+05:30 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. 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