f99278f5476437757f08c615663003d2 306341.pdf 441692703b8cf390bcb2208758ef8d41e6fcd974 306341.pdf bb501c7b026be60d254afebad854272719b6f7c3218cf95170827ef65c0f6064 306341.pdf Title: Vers un diagnostic biologique sanguin de la maladie d’Alzheimer ? Subject: Med Sci (Paris) 2024 \; 40 : 351–359. DOI: 10.1051/medsci/2024037 Keywords: Author: Delaby Constance, Lehmann Sylvain Creator: Adobe InDesign 18.0 (Windows) Producer: Adobe PDF Library 17.0 CreationDate: Fri Apr 12 14:24:59 2024 CEST ModDate: Mon Apr 22 13:01:40 2024 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 9 Encrypted: no Page size: 595.416 x 765.494 pts Page rot: 0 File size: 2089455 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ROSQCP+SymbolMT CID TrueType Identity-H yes yes yes 153 0 SPCPQN+TarzanaWideOT-Bold Type 1C Custom yes yes yes 156 0 JAFTUF+TarzanaNarOT-Regular Type 1C Custom yes yes yes 159 0 WLZMVG+TarzanaNarOT-Italic Type 1C Custom yes yes yes 161 0 SKHARO+Futura-BoldOblique Type 1C WinAnsi yes yes no 163 0 ROMZCP+TarzanaNarOT-Bold Type 1C Custom yes yes yes 166 0 AWFSYX+Helvetica Type 1C WinAnsi yes yes no 168 0 PONUAT+SymbolMT CID TrueType Identity-H yes yes yes 92 0 ULCDSJ+TarzanaNarOT-Bold Type 1C Custom yes yes no 90 0 OMEYMV+TarzanaNarOT-Regular Type 1C Custom yes yes no 91 0 UKJSSJ+TarzanaNarOT-BoldItalic Type 1C Custom yes yes yes 94 0 WLZMVG+TarzanaNarOT-Italic Type 1C WinAnsi yes yes yes 96 0 JAFTUF+TarzanaNarOT-Regular Type 1C WinAnsi yes yes yes 97 0 NIPSYX+TarzanaNarOT-Bold Type 1C Custom yes yes no 100 0 OMEYMV+TarzanaNarOT-Regular Type 1C Custom yes yes no 101 0 WLZMVG+TarzanaNarOT-Italic Type 1C WinAnsi yes yes yes 103 0 OEGYMV+TarzanaWideOT-Regular Type 1C WinAnsi yes yes yes 106 0 SKHARO+Futura-BoldOblique Type 1C WinAnsi yes yes no 108 0 BQQTMV+TimesNewRomanPS-BoldMT TrueType WinAnsi yes yes yes 107 0 OUCTMV+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 109 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-01-28 02:39:59 CET RepresentationInformation: 306341.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-01-27 14:04:28 CET Size: 2089455 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 400 FreeObjects: 100 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Les biomarqueurs liés au processus pathologique : amyloïdes et tau Item: Title: Biomarqueurs de neurodégénérescence Item: Title: Les neurofilament light chain proteins Item: Title: La S100b et la NSE Item: Title: Les biomarqueurs réactionnels Item: Title: Les biomarqueurs de la neuro-inflammation Item: Title: Les autres biomarqueurs réactionnels Item: Title: Biomarqueurs métaboliques et de retour à l’homéostasie Item: Title: Les lipides Item: Title: L’apolipoprotéine E Item: Title: Les facteurs neurotrophiques Item: Title: Les biomarqueurs intestinaux et de l’obésité Item: Title: Diabètes et biomarqueurs glycémiques Item: Title: Considérations pratiques et conclusion Item: Title: SUMMARY Item: Title: LIENS D’INTÉRÊT Item: Title: RÉFÉRENCES Item: Title: RÉFÉRENCES Info: Title: Vers un diagnostic biologique sanguin de la maladie d’Alzheimer ? Author: Delaby Constance, Lehmann Sylvain Subject: Med Sci (Paris) 2024 \; 40 : 351–359. DOI: 10.1051/medsci/2024037 Keywords: Creator: Adobe InDesign 18.0 (Windows) Producer: Adobe PDF Library 17.0 CreationDate: Fri Apr 12 14:24:59 CEST 2024 ModDate: Mon Apr 22 13:01:40 CEST 2024 ID: 0xa511d40a715e060fbcfbbea30faf00c6, 0xa511d40a715e060fbcfbbea30faf00c6 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 418 ImageHeight: 371 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 592 ImageHeight: 448 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 592 ImageHeight: 448 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 592 ImageHeight: 448 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 149 ImageHeight: 894 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 592 ImageHeight: 447 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 592 ImageHeight: 447 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 592 ImageHeight: 447 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 955 ImageHeight: 730 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1146 ImageHeight: 913 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1146 ImageHeight: 913 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1337 ImageHeight: 730 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 383 ImageHeight: 1641 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1068 ImageHeight: 908 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 930 ImageHeight: 772 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: ROSQCP+SymbolMT Encoding: Identity-H ToUnicode: true Font: BaseFont: PONUAT+SymbolMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: WLZMVG+TarzanaNarOT-Italic FontSubset: true FirstChar: 31 LastChar: 252 FontDescriptor: FontName: WLZMVG+TarzanaNarOT-Italic Flags: Nonsymbolic, Italic FontBBox: -157, -216, 829, 904 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SKHARO+Futura-BoldOblique FontSubset: true FirstChar: 47 LastChar: 233 FontDescriptor: FontName: SKHARO+Futura-BoldOblique Flags: Nonsymbolic, Italic FontBBox: -213, -264, 1606, 1040 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NIPSYX+TarzanaNarOT-Bold FontSubset: true FirstChar: 20 LastChar: 31 FontDescriptor: FontName: NIPSYX+TarzanaNarOT-Bold Flags: Symbolic FontBBox: -40, -228, 844, 927 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OMEYMV+TarzanaNarOT-Regular FontSubset: true FirstChar: 5 LastChar: 31 FontDescriptor: FontName: OMEYMV+TarzanaNarOT-Regular Flags: Symbolic FontBBox: -39, -216, 854, 904 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ROMZCP+TarzanaNarOT-Bold FontSubset: true FirstChar: 30 LastChar: 244 FontDescriptor: FontName: ROMZCP+TarzanaNarOT-Bold Flags: Nonsymbolic FontBBox: -40, -228, 844, 927 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: AWFSYX+Helvetica FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: AWFSYX+Helvetica Flags: Nonsymbolic FontBBox: -951, -481, 1446, 1122 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OEGYMV+TarzanaWideOT-Regular FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: OEGYMV+TarzanaWideOT-Regular Flags: Nonsymbolic FontBBox: -69, -232, 1182, 944 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: SKHARO+Futura-BoldOblique FontSubset: true FirstChar: 47 LastChar: 233 FontDescriptor: FontName: SKHARO+Futura-BoldOblique Flags: Nonsymbolic, Italic FontBBox: -213, -264, 1606, 1040 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ULCDSJ+TarzanaNarOT-Bold FontSubset: true FirstChar: 4 LastChar: 31 FontDescriptor: FontName: ULCDSJ+TarzanaNarOT-Bold Flags: Symbolic FontBBox: -40, -228, 844, 927 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: OMEYMV+TarzanaNarOT-Regular FontSubset: true FirstChar: 1 LastChar: 173 FontDescriptor: FontName: OMEYMV+TarzanaNarOT-Regular Flags: Symbolic FontBBox: -39, -216, 854, 904 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: SPCPQN+TarzanaWideOT-Bold FontSubset: true FirstChar: 31 LastChar: 244 FontDescriptor: FontName: SPCPQN+TarzanaWideOT-Bold Flags: Nonsymbolic FontBBox: -90, -234, 1223, 964 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: UKJSSJ+TarzanaNarOT-BoldItalic FontSubset: true FirstChar: 31 LastChar: 244 FontDescriptor: FontName: UKJSSJ+TarzanaNarOT-BoldItalic Flags: Nonsymbolic, Italic FontBBox: -154, -228, 820, 927 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: JAFTUF+TarzanaNarOT-Regular FontSubset: true FirstChar: 28 LastChar: 252 FontDescriptor: FontName: JAFTUF+TarzanaNarOT-Regular Flags: Nonsymbolic FontBBox: -39, -216, 854, 904 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true TrueType: Font: BaseFont: BQQTMV+TimesNewRomanPS-BoldMT FontSubset: true FirstChar: 32 LastChar: 224 FontDescriptor: FontName: BQQTMV+TimesNewRomanPS-BoldMT Flags: Serif, Nonsymbolic FontBBox: -558, -328, 2000, 1056 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: OUCTMV+TimesNewRomanPSMT FontSubset: true FirstChar: 32 LastChar: 244 FontDescriptor: FontName: OUCTMV+TimesNewRomanPSMT Flags: Serif, Nonsymbolic FontBBox: -568, -307, 2046, 1040 FontFile2: true Encoding: WinAnsiEncoding ToUnicode: true CIDFontType2: Font: BaseFont: ROSQCP+SymbolMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ROSQCP+SymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile2: true Font: BaseFont: WOBPUF+SymbolMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WOBPUF+SymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile2: true Pages: Page: Label: 351 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 138, 42, 243, 50 Annotation: Subtype: Link Rect: 181, 748, 229, 755 Annotation: Subtype: Link Rect: 490, 107, 503, 119 ActionDest: 1 Annotation: Subtype: Link Rect: 240, 333, 252, 345 ActionDest: 1 Annotation: Subtype: Link Rect: 525, 372, 565, 383 ActionDest: 1 Page: Label: 352 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 196, 407, 209, 419 ActionDest: 1 Annotation: Subtype: Link Rect: 207, 408, 220, 419 ActionDest: 1 Annotation: Subtype: Link Rect: 306, 371, 319, 382 ActionDest: 1 Annotation: Subtype: Link Rect: 315, 371, 328, 382 ActionDest: 1 Annotation: Subtype: Link Rect: 409, 407, 422, 419 ActionDest: 1 Annotation: Subtype: Link Rect: 269, 294, 282, 306 ActionDest: 1 Annotation: Subtype: Link Rect: 274, 246, 287, 258 ActionDest: 1 Annotation: Subtype: Link Rect: 157, 183, 170, 194 ActionDest: 1 Annotation: Subtype: Link Rect: 433, 208, 445, 220 ActionDest: 1 Annotation: Subtype: Link Rect: 450, 208, 462, 220 ActionDest: 1 Annotation: Subtype: Link Rect: 372, 118, 384, 129 ActionDest: 1 Page: Label: 353 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 266, 585, 278, 597 ActionDest: 1 Annotation: Subtype: Link Rect: 161, 496, 173, 508 ActionDest: 1 Annotation: Subtype: Link Rect: 538, 611, 551, 623 ActionDest: 1 Annotation: Subtype: Link Rect: 359, 498, 371, 510 ActionDest: 1 Annotation: Subtype: Link Rect: 443, 458, 455, 470 ActionDest: 1 Annotation: Subtype: Link Rect: 192, 446, 204, 458 ActionDest: 1 Annotation: Subtype: Link Rect: 231, 409, 243, 421 ActionDest: 1 Annotation: Subtype: Link Rect: 170, 359, 182, 370 ActionDest: 1 Annotation: Subtype: Link Rect: 85, 383, 97, 394 ActionDest: 1 Annotation: Subtype: Link Rect: 275, 246, 286, 257 ActionDest: 1 Annotation: Subtype: Link Rect: 532, 336, 544, 347 ActionDest: 1 Annotation: Subtype: Link Rect: 450, 143, 461, 155 ActionDest: 1 Annotation: Subtype: Link Rect: 438, 81, 450, 93 ActionDest: 1 Page: Label: 354 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 457, 309, 469, 320 ActionDest: 1 Annotation: Subtype: Link Rect: 187, 106, 199, 118 ActionDest: 1 Annotation: Subtype: Link Rect: 522, 82, 533, 94 ActionDest: 1 Annotation: Subtype: Link Rect: 127, 321, 138, 332 ActionDest: 1 Annotation: Subtype: Link Rect: 122, 259, 133, 271 ActionDest: 1 Annotation: Subtype: Link Rect: 105, 258, 117, 270 ActionDest: 1 Annotation: Subtype: Link Rect: 439, 209, 451, 221 ActionDest: 1 Annotation: Subtype: Link Rect: 464, 271, 503, 283 ActionDest: 1 Annotation: Subtype: Link Rect: 83, 321, 120, 333 ActionDest: 1 Page: Label: 355 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 279, 622, 291, 633 ActionDest: 1 Annotation: Subtype: Link Rect: 469, 624, 481, 635 ActionDest: 1 Annotation: Subtype: Link Rect: 185, 535, 197, 547 ActionDest: 1 Annotation: Subtype: Link Rect: 509, 523, 520, 535 ActionDest: 1 Annotation: Subtype: Link Rect: 462, 397, 473, 409 ActionDest: 1 Annotation: Subtype: Link Rect: 169, 385, 180, 397 ActionDest: 1 Annotation: Subtype: Link Rect: 272, 220, 283, 232 ActionDest: 1 Annotation: Subtype: Link Rect: 435, 296, 447, 308 ActionDest: 1 Annotation: Subtype: Link Rect: 492, 134, 504, 145 ActionDest: 1 Annotation: Subtype: Link Rect: 268, 81, 279, 93 ActionDest: 1 Page: Label: 356 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 101, 411, 112, 423 ActionDest: 1 Annotation: Subtype: Link Rect: 121, 219, 133, 231 ActionDest: 1 Annotation: Subtype: Link Rect: 527, 82, 539, 93 ActionDest: 1 Annotation: Subtype: Link Rect: 411, 561, 459, 572 ActionDest: 1 Annotation: Subtype: Link Rect: 358, 296, 399, 308 ActionDest: 1 Annotation: Subtype: Link Rect: 445, 220, 483, 232 ActionDest: 1 Page: Label: 357 Sequence: 7 Page: Label: 358 Sequence: 8 Page: Label: 359 Sequence: 9 Checksum: cab7acf1 Type: CRC32 Checksum: f99278f5476437757f08c615663003d2 Type: MD5 Checksum: 441692703b8cf390bcb2208758ef8d41e6fcd974 Type: SHA-1 Checksum: bb501c7b026be60d254afebad854272719b6f7c3218cf95170827ef65c0f6064 Type: SHA-256