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e56c321654fe1ec4c974cbbfb7c090055e1c499576d887600ca138b0394c7e73  306343.pdf

Title:           Sex- and Gender-Based Analysis on Norepinephrine Use in Septic Shock: Why Is It Still a Male World?
Subject:         Sex and gender are fundamental health determinants and their role as modifiers of treatment response is increasingly recognized. Norepinephrine is a cornerstone of septic shock management and its use is based on the highest level of evidence compared to dopamine. The related 2021 Surviving Sepsis Campaign (SCC) recommendation is presumably applicable to both females and males; however, a sex- and gender-based analysis is lacking, thus not allowing generalizable conclusions. This paper was aimed at exploring whether sex- and gender-disaggregated data are available in the evidence supporting this recommendation. For all the studies underpinning it, four pairs of authors, including a woman and a man, extracted data concerning sex and gender, according to the Sex and Gender Equity in Research guidelines. Nine manuscripts were included with an overall population of 2126 patients, of which 43.2% were females. No sex analysis was performed and gender was never reported. In conclusion, the present manuscript highlighted that the clinical studies underlying the SCC recommendation of NE administration in septic shock have neglected the likely role of sex and gender as modifiers of treatment response, thus missing the opportunity of sex- and gender-specific guidelines.
Keywords:        sex; gender; septic shock; norepinephrine; vasoactive agents; precision medicine
Author:          Benedetta Perna, Valeria Raparelli, Federica Tordo Caprioli, Oana Teodora Blanaru, Cecilia Malacarne, Cecilia Crosetti, Andrea Portoraro, Alex Zanotto, Francesco Maria Strocchi, Alessandro Rapino, Anna Costanzini, Martina Maritati, Roberto Lazzari, Michele Domenico Spampinato, Carlo Contini, Roberto De Giorgio and Matteo Guarino
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    Title: Sex- and Gender-Based Analysis on Norepinephrine Use in Septic Shock: Why Is It Still a Male World?
    Author: Benedetta Perna, Valeria Raparelli, Federica Tordo Caprioli, Oana Teodora Blanaru, Cecilia Malacarne, Cecilia Crosetti, Andrea Portoraro, Alex Zanotto, Francesco Maria Strocchi, Alessandro Rapino, Anna Costanzini, Martina Maritati, Roberto Lazzari, Michele Domenico Spampinato, Carlo Contini, Roberto De Giorgio and Matteo Guarino
    Subject: Sex and gender are fundamental health determinants and their role as modifiers of treatment response is increasingly recognized. Norepinephrine is a cornerstone of septic shock management and its use is based on the highest level of evidence compared to dopamine. The related 2021 Surviving Sepsis Campaign (SCC) recommendation is presumably applicable to both females and males; however, a sex- and gender-based analysis is lacking, thus not allowing generalizable conclusions. This paper was aimed at exploring whether sex- and gender-disaggregated data are available in the evidence supporting this recommendation. For all the studies underpinning it, four pairs of authors, including a woman and a man, extracted data concerning sex and gender, according to the Sex and Gender Equity in Research guidelines. Nine manuscripts were included with an overall population of 2126 patients, of which 43.2% were females. No sex analysis was performed and gender was never reported. In conclusion, the present manuscript highlighted that the clinical studies underlying the SCC recommendation of NE administration in septic shock have neglected the likely role of sex and gender as modifiers of treatment response, thus missing the opportunity of sex- and gender-specific guidelines.
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  Checksum: aa0cba5c
   Type: CRC32
  Checksum: ecb660071756f0f52f06c330ddf8109f
   Type: MD5
  Checksum: 8be350daeabe83222e8747de769754c279feaadd
   Type: SHA-1
  Checksum: e56c321654fe1ec4c974cbbfb7c090055e1c499576d887600ca138b0394c7e73
   Type: SHA-256