3145e2aebff8b346d2869bfcad46881b 306946.pdf 23af0eb7d7e2dc9098c9ab4e59ce166da5d65753 306946.pdf 9312d9a5e97d02b69955f455e7fe4e4987c95590d13621a45f6271d610c8b59c 306946.pdf Title: Colchicine in acute heart failure: Rationale and design of a randomized double‐blind placebo‐controlled trial (COLICA) Subject: European J of Heart Fail 2024.26:1999-2007 Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 11.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Fri Sep 6 16:00:42 2024 CEST ModDate: Tue Feb 4 19:32:42 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 704823 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- STIXMath-Italic Type 1C Custom yes no yes 39 0 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'ejhf3300-note-0004' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3300-note-0005' cannot be found ID: PDF-HUL-122 Offset: 454764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'ejhf3300-note-0004' cannot be found ID: PDF-HUL-122 Offset: 454764 MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Colchicine in acute heart failure: Rationale and design of a randomized double-blind placebo-controlled trial (COLICA) Destination: section*.1 Item: Title: Introduction Destination: section*.2 Item: Title: Methods Destination: section*.3 Item: Title: Study design Destination: section*.4 Item: Title: Study population Destination: section*.5 Item: Title: Randomization and study drug Destination: section*.6 Item: Title: Study endpoints Destination: section*.7 Item: Title: Follow-up and study procedures Destination: section*.8 Item: Title: Statistical plan Destination: section*.9 Item: Title: Ethical and administrative considerations Destination: section*.10 Item: Title: Discussion Destination: section*.11 Item: Title: Role of the interleukin-1 axis Destination: section*.12 Item: Title: Role of interleukin-1-based anti-inflammatory therapies Destination: section*.13 Item: Title: Rationale for the use of colchicine Destination: section*.14 Item: Title: Rationale for the selected population, short-duration treatment and endpoints Destination: section*.15 Item: Title: Limitations Destination: section*.16 Item: Title: Conclusion Destination: section*.17 Item: Title: Acknowledgements Destination: section*.18 Item: Title: Funding Destination: section*.19 Item: Title: Appendix Destination: section*.20 Item: Title: COLICA Investigators Destination: section*.21 Item: Title: References 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