bec3f9f4ea174ac2300e43888bedee50 306952.pdf e261bf99b2429ea2687e9f7ad3da2f5b137aaf49 306952.pdf 225d03c8687dcd7eb5e0b1cefbb3087f554b3db0c9e4227ab6367f165a4d669b 306952.pdf Title: Healthcare and Epidemiological Surveillance Costs of Hepatitis A Outbreaks in Spain in Regions with and without Universal Hepatitis A Vaccination of Children during 2010-2018 Subject: The aim of this study was to evaluate and compare hepatitis A outbreak-associated healthcare and epidemiological surveillance costs in Spain in two types of autonomous regions during 2010–2018: (1) regions with a prevention strategy based on universal hepatitis A vaccination of children and vaccination of high-risk population groups (Catalonia) and (2) regions with a prevention strategy based on vaccinating high-risk population groups (Castile and Leon, Murcia, Navarra, Community of Madrid, Community of Valencia). Healthcare costs were determined based on the resources used to treat hepatitis A outbreak-associated cases and hospitalizations. Epidemiological surveillance costs were calculated from the resources used during surveillance activities. The ratios for total, healthcare and epidemiological surveillance costs (regions without universal hepatitis A vaccination of children vs. Catalonia) were used to compare the two hepatitis A prevention strategies. From 2010 to 2018, the total, healthcare and epidemiological surveillance costs per million population were 1.75 times (EUR 101,671 vs. EUR 58,032), 1.96 times (EUR 75,500 vs. EUR 38,516) and 1.34 times greater (EUR 26,171 vs. EUR 19,515) in regions without universal hepatitis A vaccination of children than in Catalonia, respectively. The ratios tended to increase over time during 2010–2018. In 2015–2018, total, healthcare and epidemiological surveillance costs per million population were 2.68 times (EUR 69,993 vs. EUR 26,158), 2.86 times (EUR 53,807 vs. EUR 18,825) and 2.21 times greater (EUR 16,186 vs. EUR 7333) in regions without universal hepatitis A vaccination of children than in Catalonia, respectively. These findings suggest that universal hepatitis A vaccination of children could reduce hepatitis A outbreak-associated costs. Keywords: hepatitis A vaccine; hepatitis A prevention; hepatitis A outbreak-associated costs;epidemiological surveillance costs; healthcare costs; hepatitis A outbreaks Author: Pedro Plans-Rubió, Carles Pericas, Ana Maria Avellon, Concepción Izquierdo, Ana Martínez, Núria Torner, Alejandro Martínez, Eva Borrás, Francisco Roig, Pere Godoy and Cristina Rius Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Tue Jun 11 10:36:24 2024 CEST ModDate: Tue Jun 11 10:47:35 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 288402 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JCYIDT+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 HOOFHR+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 NSHEGG+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 UTAYBE+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 ACKGZT+VnURWPalladioL Type 1 Custom yes yes yes 32 0 JDUPKS+CMSY10 Type 1 Builtin yes yes yes 68 0 NMTXOM+VnURWPalladioL-Italic Type 1 Custom yes yes yes 94 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-05 02:42:03 CET RepresentationInformation: 306952.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-04 20:04:39 CET Size: 288402 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 303 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design Destination: subsection.2.1 Item: Title: Healthcare Costs of Hepatitis A Outbreaks Destination: subsection.2.2 Item: Title: Epidemiological Surveillance Costs of Hepatitis A Outbreaks Destination: subsection.2.3 Item: Title: Total Costs of Hepatitis A Outbreaks Destination: subsection.2.4 Item: Title: Statistical Analysis Destination: subsection.2.5 Item: Title: Results Destination: section.3 Children: Item: Title: Healthcare and Epidemiological Surveillance Costs of Hepatitis A Outbreaks Destination: subsection.3.1 Item: Title: Healthcare Costs per Million Population of Hepatitis A Outbreaks Destination: subsection.3.2 Item: Title: Epidemiological Surveillance Costs per Million Population of Hepatitis A Outbreaks Destination: subsection.3.3 Item: Title: Total Health Costs per Million Population of Hepatitis A Outbreaks Destination: subsection.3.4 Item: Title: Tendencies for Study Outcome over Time during 2010 2018 Destination: subsection.3.5 Item: Title: Sensitivity Analysis Destination: subsection.3.6 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: appendix.A. Info: Title: Healthcare and Epidemiological Surveillance Costs of Hepatitis A Outbreaks in Spain in Regions with and without Universal Hepatitis A Vaccination of Children during 2010-2018 Author: Pedro Plans-Rubió, Carles Pericas, Ana Maria Avellon, Concepción Izquierdo, Ana Martínez, Núria Torner, Alejandro Martínez, Eva Borrás, Francisco Roig, Pere Godoy and Cristina Rius Subject: The aim of this study was to evaluate and compare hepatitis A outbreak-associated healthcare and epidemiological surveillance costs in Spain in two types of autonomous regions during 2010 2018: (1) regions with a prevention strategy based on universal hepatitis A vaccination of children and vaccination of high-risk population groups (Catalonia) and (2) regions with a prevention strategy based on vaccinating high-risk population groups (Castile and Leon, Murcia, Navarra, Community of Madrid, Community of Valencia). Healthcare costs were determined based on the resources used to treat hepatitis A outbreak-associated cases and hospitalizations. Epidemiological surveillance costs were calculated from the resources used during surveillance activities. The ratios for total, healthcare and epidemiological surveillance costs (regions without universal hepatitis A vaccination of children vs. Catalonia) were used to compare the two hepatitis A prevention strategies. From 2010 to 2018, the total, healthcare and epidemiological surveillance costs per million population were 1.75 times (EUR 101,671 vs. EUR 58,032), 1.96 times (EUR 75,500 vs. EUR 38,516) and 1.34 times greater (EUR 26,171 vs. EUR 19,515) in regions without universal hepatitis A vaccination of children than in Catalonia, respectively. The ratios tended to increase over time during 2010 2018. In 2015 2018, total, healthcare and epidemiological surveillance costs per million population were 2.68 times (EUR 69,993 vs. EUR 26,158), 2.86 times (EUR 53,807 vs. EUR 18,825) and 2.21 times greater (EUR 16,186 vs. EUR 7333) in regions without universal hepatitis A vaccination of children than in Catalonia, respectively. These findings suggest that universal hepatitis A vaccination of children could reduce hepatitis A outbreak-associated costs. 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