d916bc1ca2453b7168d48f4ad83e395e 306965.pdf a44af522f6565de8225397906b0f92947236a937 306965.pdf 1e3c2eff2d561f2c5c6c3e14abfc4f7c87a4d400ef8facc70e8fd9fa9ba24df5 306965.pdf Title: Clinical Validation of Digital Healthcare Solutions: State of the Art, Challenges and Opportunities Subject: Digital health technologies (DHTs) at the intersection of health, medical informatics, and business aim to enhance patient care through personalised digital approaches. Ensuring the efficacy and reliability of these innovations demands rigorous clinical validation. A PubMed literature review (January 2006 to July 2023) identified 1250 papers, highlighting growing academic interest. A focused narrative review (January 2018 to July 2023) delved into challenges, highlighting issues such as diverse regulatory landscapes, adoption issues in complex healthcare systems, and a plethora of evaluation frameworks lacking pragmatic guidance. Existing frameworks often omit crucial criteria, neglect empirical evidence, and clinical effectiveness is rarely included as a criterion for DHT quality. The paper underscores the urgency of addressing challenges in accreditation, adoption, business models, and integration to safeguard the quality, efficacy, and safety of DHTs. A pivotal illustration of collaborative efforts to address these challenges is exemplified by the Digital Health Validation Center, dedicated to generating clinical evidence of innovative healthcare technologies and facilitating seamless technology transfer. In conclusion, it is necessary to harmonise evaluation approaches and frameworks, improve regulatory clarity, and commit to collaboration to integrate rigorous clinical validation and empirical evidence throughout the DHT life cycle. Keywords: digital health technologies; clinical validation; adoption challenges; evaluation frameworks; empirical evidence; technology transfer; eHealth; healthcare digitalisation; innovation; patient care Author: Mar Gomis-Pastor, Jesús Berdún, Alicia Borrás-Santos, Anna De Dios López, Beatriz Fernández-Montells Rama, Óscar García-Esquirol, Mònica Gratacòs, Gerardo D. Ontiveros Rodríguez, Rebeca Pelegrín Cruz, Jordi Real, Jordi Bachs i Ferrer and Adrià Comella Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Tue Jun 4 10:43:29 2024 CEST ModDate: Tue Jun 4 10:50:18 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 21 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 7723294 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MXMSUU+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 POEKRV+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 NIMIOG+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 KIUMRV+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 NTQZMS+VnURWPalladioL Type 1 Custom yes yes yes 32 0 XAOEUN+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 ONDMKP+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 122 0 ONDMLB+PalatinoLinotype TrueType WinAnsi yes yes no 125 0 ONDMMC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 128 0 ONDNAC+PalatinoLinotype TrueType MacRoman yes yes no 131 0 ONDMKP+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 200 0 ONDMLB+PalatinoLinotype TrueType WinAnsi yes yes no 203 0 ONDMMC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 206 0 ONDNAC+PalatinoLinotype TrueType MacRoman yes yes no 209 0 ONDMKP+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 240 0 ONDMLB+PalatinoLinotype TrueType WinAnsi yes yes no 243 0 ONDMMC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 246 0 ONDNAC+PalatinoLinotype TrueType MacRoman yes yes no 249 0 ONDMKP+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 305 0 ONDMLA+PalatinoLinotype CID TrueType Identity-H yes yes yes 308 0 ONDMLB+PalatinoLinotype TrueType WinAnsi yes yes no 314 0 ONDMMC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 317 0 ONDNAC+PalatinoLinotype TrueType MacRoman yes yes no 320 0 ONDMKP+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 342 0 ONDMLA+PalatinoLinotype CID TrueType Identity-H yes yes yes 345 0 ONDMLB+PalatinoLinotype TrueType WinAnsi yes yes no 351 0 ONDMMC+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 354 0 ONDNAC+PalatinoLinotype TrueType MacRoman yes yes no 357 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-07 02:47:12 CET RepresentationInformation: 306965.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-06 19:41:31 CET Size: 7723294 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 771 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Search Strategy Destination: subsection.2.1 Item: Title: Bibliometric and Visual Analysis Destination: subsection.2.2 Item: Title: Literature Review and Data Collection Destination: subsection.2.3 Item: Title: Results Destination: section.3 Children: Item: Title: Bibliometric and Visual Analysis Destination: subsection.3.1 Item: Title: Literature Review Destination: subsection.3.2 Children: Item: Title: Challenges Faced When Evaluating Digital Health Technologies Destination: subsubsection.3.2.1 Item: Title: Reviews of DHTs Evaluation Frameworks Destination: subsubsection.3.2.2 Item: Title: Articles Proposing a Multidimensional Evaluation Framework or Model Destination: subsubsection.3.2.3 Item: Title: Articles Proposing or Reviewing Specific Evaluation Dimensions Destination: subsubsection.3.2.4 Item: Title: Discussion Destination: section.4 Children: Item: Title: New Opportunities Destination: subsection.4.1 Item: Title: Limitations Destination: subsection.4.2 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: appendix.A. Info: Title: Clinical Validation of Digital Healthcare Solutions: State of the Art, Challenges and Opportunities Author: Mar Gomis-Pastor, Jesús Berdún, Alicia Borrás-Santos, Anna De Dios López, Beatriz Fernández-Montells Rama, Óscar García-Esquirol, Mònica Gratacòs, Gerardo D. Ontiveros Rodríguez, Rebeca Pelegrín Cruz, Jordi Real, Jordi Bachs i Ferrer and Adrià Comella Subject: Digital health technologies (DHTs) at the intersection of health, medical informatics, and business aim to enhance patient care through personalised digital approaches. Ensuring the efficacy and reliability of these innovations demands rigorous clinical validation. A PubMed literature review (January 2006 to July 2023) identified 1250 papers, highlighting growing academic interest. A focused narrative review (January 2018 to July 2023) delved into challenges, highlighting issues such as diverse regulatory landscapes, adoption issues in complex healthcare systems, and a plethora of evaluation frameworks lacking pragmatic guidance. Existing frameworks often omit crucial criteria, neglect empirical evidence, and clinical effectiveness is rarely included as a criterion for DHT quality. The paper underscores the urgency of addressing challenges in accreditation, adoption, business models, and integration to safeguard the quality, efficacy, and safety of DHTs. A pivotal illustration of collaborative efforts to address these challenges is exemplified by the Digital Health Validation Center, dedicated to generating clinical evidence of innovative healthcare technologies and facilitating seamless technology transfer. In conclusion, it is necessary to harmonise evaluation approaches and frameworks, improve regulatory clarity, and commit to collaboration to integrate rigorous clinical validation and empirical evidence throughout the DHT life cycle. 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