0846eddee32a8523479f1b223431791c  MIN_a2024v26.pdf
13d1ef5f031322e4bbb9a52027852b7421c5ef3a  MIN_a2024v26.pdf
fb8edb6ce16574fa812f97923171ba95049a5764e273b1ea65a0369f82bfb01c  MIN_a2024v26.pdf

Title:           Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
Subject:         Microbes and Infection, 26 (2024) 105252. doi:10.1016/j.micinf.2023.105252
Author:          Jordi Rodon
Creator:         Elsevier
Producer:        Acrobat Distiller 8.1.0 (Windows)
CreationDate:    Fri Mar 15 19:40:25 2024 CET
ModDate:         Fri Mar 15 19:41:05 2024 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           6
Encrypted:       no
Page size:       595.276 x 793.701 pts
Page rot:        0
File size:       2439038 bytes
Optimized:       yes
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
CNBPIE+AdvOT863180fb                 Type 1C           WinAnsi          yes yes no     368  0
CNBPIF+AdvOT863180fb+fb              Type 1C           Custom           yes yes yes    373  0
CNBPIG+AdvP4C4E59                    Type 1C           Custom           yes yes yes    378  0
CNBPIH+AdvTT5843c571                 Type 1C           WinAnsi          yes yes no     381  0
CNBPII+AdvOTb92eb7df.I               Type 1C           WinAnsi          yes yes no     366  0
CNBPJJ+AdvOTc4d0b532                 Type 1C           WinAnsi          yes yes no     384  0
CNBPJK+AdvOTb0c9bf5d                 Type 1C           WinAnsi          yes yes no     386  0
CNBPJL+AdvP3F4C13                    Type 1C           WinAnsi          yes yes no     390  0
CNBPJM+AdvPS44A44B                   Type 1C           WinAnsi          yes yes no     392  0
CNBPMM+AdvPSA35D                     Type 1C           WinAnsi          yes yes no     398  0
CNBPON+AdvP4C4E74                    Type 1C           Custom           yes yes yes    173  0
CNBPOO+AdvP4721B4                    Type 1C           WinAnsi          yes yes no     174  0
CNBPOP+AdvOTb92eb7df.I+fb            Type 1C           Custom           yes yes yes    163  0
CNBPNM+AdvOTb83ee1dd.B               Type 1C           WinAnsi          yes yes no     164  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-02-06 03:01:49 CET
 RepresentationInformation: MIN_a2024v26.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-02-05 14:17:12 CET
  Size: 2439038
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found
   ID: PDF-HUL-122
   Offset: 2419887
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 455
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replicat ...
      Destination: titlink1
      Children: 
       Item: 
        Title: 1. Materials and methods
        Destination: flink1
        Children: 
         Item: 
          Title: 1.1. Animal welfare and ethics
          Destination: slink1
         Item: 
          Title: 1.2. Cell culture and MERS-CoV
          Destination: slink2
         Item: 
          Title: 1.3. Isolation of llama alveolar macrophages
          Destination: slink3
         Item: 
          Title: 1.4. MERS-CoV exposure assays
          Destination: slink4
         Item: 
          Title: 1.5. Virus titration in cell culture
          Destination: slink5
         Item: 
          Title: 1.6. Cellular RNA extraction
          Destination: slink6
         Item: 
          Title: 1.7. cDNA synthesis
          Destination: slink7
         Item: 
          Title: 1.8. Transcriptomic analyses by microfluidic RT-qPCR
          Destination: slink8
         Item: 
          Title: 1.9. Relative immune response gene quantification and data analysis
          Destination: slink9
         Item: 
          Title: 1.10. Transmission electron microscopy (TEM)
          Destination: slink10
       Item: 
        Title: 2. Results
        Destination: flink2
       Item: 
        Title: 3. Discussion
        Destination: flink3
       Item: 
        Title: Author contributions
        Destination: flink4
       Item: 
        Title: Declaration of competing interest
        Destination: aclink8
       Item: 
        Title: Acknowledgements
        Destination: aclink9
       Item: 
        Title: Appendix A. Supplementary data
        Destination: flink5
       Item: 
        Title: References
        Destination: blink1
   Info: 
    Title: Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
    Author: Jordi Rodon
    Subject: Microbes and Infection, 26 (2024) 105252. doi:10.1016/j.micinf.2023.105252
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Fri Mar 15 20:10:25 CET 2024
    ModDate: Fri Mar 15 20:11:05 CET 2024
   ID: 0x534bed9027aa927b26d99d11f0357b50, 0xb184ad697530ff4ba2c52697cdfe2aad
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 120
      ImageHeight: 119
      ColorSpace: palette color
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 237
      ImageHeight: 299
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 254
      ImageHeight: 278
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2104
      ImageHeight: 2681
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1895
      ImageHeight: 2112
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: CNBPJJ+AdvOTc4d0b532
      FontSubset: true
      FirstChar: 97
      LastChar: 116
      FontDescriptor: 
       FontName: CNBPJJ+AdvOTc4d0b532
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CNBPJK+AdvOTb0c9bf5d
      FontSubset: true
      FirstChar: 60
      LastChar: 177
      FontDescriptor: 
       FontName: CNBPJK+AdvOTb0c9bf5d
       Flags: Nonsymbolic
       FontBBox: -62, -208, 927, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CNBPOP+AdvOTb92eb7df.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: CNBPOP+AdvOTb92eb7df.I+fb
       Flags: Symbolic
       FontBBox: -114, -208, 833, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: CNBPNM+AdvOTb83ee1dd.B
      FontSubset: true
      FirstChar: 46
      LastChar: 121
      FontDescriptor: 
       FontName: CNBPNM+AdvOTb83ee1dd.B
       Flags: Serif, Nonsymbolic
       FontBBox: -93, -250, 1041, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CNBPJL+AdvP3F4C13
      FontSubset: true
      FirstChar: 68
      LastChar: 115
      FontDescriptor: 
       FontName: CNBPJL+AdvP3F4C13
       Flags: Nonsymbolic
       FontBBox: 0, -291, 875, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CNBPJM+AdvPS44A44B
      FontSubset: true
      FirstChar: 101
      LastChar: 101
      FontDescriptor: 
       FontName: CNBPJM+AdvPS44A44B
       Flags: Nonsymbolic
       FontBBox: 0, -197, 1000, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CNBPON+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 254
      FontDescriptor: 
       FontName: CNBPON+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: CNBPMM+AdvPSA35D
      FontSubset: true
      FirstChar: 46
      LastChar: 119
      FontDescriptor: 
       FontName: CNBPMM+AdvPSA35D
       Flags: Nonsymbolic
       FontBBox: -166, -239, 989, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CNBPII+AdvOTb92eb7df.I
      FontSubset: true
      FirstChar: 39
      LastChar: 237
      FontDescriptor: 
       FontName: CNBPII+AdvOTb92eb7df.I
       Flags: Serif, Nonsymbolic
       FontBBox: -135, -229, 1052, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CNBPOO+AdvP4721B4
      FontSubset: true
      FirstChar: 109
      LastChar: 109
      FontDescriptor: 
       FontName: CNBPOO+AdvP4721B4
       Flags: Nonsymbolic
       FontBBox: 0, -208, 843, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CNBPIE+AdvOT863180fb
      FontSubset: true
      FirstChar: 35
      LastChar: 250
      FontDescriptor: 
       FontName: CNBPIE+AdvOT863180fb
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 979
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: CNBPIF+AdvOT863180fb+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: CNBPIF+AdvOT863180fb+fb
       Flags: Symbolic
       FontBBox: 40, 0, 895, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: CNBPIG+AdvP4C4E59
      FontSubset: true
      FirstChar: 1
      LastChar: 160
      FontDescriptor: 
       FontName: CNBPIG+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: CNBPIH+AdvTT5843c571
      FontSubset: true
      FirstChar: 38
      LastChar: 186
      FontDescriptor: 
       FontName: CNBPIH+AdvTT5843c571
       Flags: Nonsymbolic
       FontBBox: -72, -208, 927, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.micinf.2023.105252</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Jordi Rodon</rdf:li>
               <rdf:li>Martin Sachse</rdf:li>
               <rdf:li>Nigeer Te</rdf:li>
               <rdf:li>Joaquim Segalés</rdf:li>
               <rdf:li>Albert Bensaid</rdf:li>
               <rdf:li>Cristina Risco</rdf:li>
               <rdf:li>Júlia Vergara-Alert</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Alveolar macrophages</rdf:li>
               <rdf:li>Immune responses</rdf:li>
               <rdf:li>Llama</rdf:li>
               <rdf:li>Middle East respiratory syndrome coronavirus</rdf:li>
               <rdf:li>MERS-CoV</rdf:li>
               <rdf:li>Pro-inflammatory cytokines</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Microbes and Infection, 26 (2024) 105252. doi:10.1016/j.micinf.2023.105252</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>The Authors</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Microbes and Infection</prism:publicationName>
         <prism:copyright>© 2023 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur.</prism:copyright>
         <prism:issn>1286-4579</prism:issn>
         <prism:volume>26</prism:volume>
         <prism:number>3</prism:number>
         <prism:coverDisplayDate>March-April 2024</prism:coverDisplayDate>
         <prism:pageRange>105252</prism:pageRange>
         <prism:startingPage>105252</prism:startingPage>
         <prism:doi>10.1016/j.micinf.2023.105252</prism:doi>
         <prism:url>https://doi.org/10.1016/j.micinf.2023.105252</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.micinf.2023.105252</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <eMmMVnduPowz-ztaGowqMn8NNzdeOlwf.otmGy.j7m9aNngv8zd2Jo9eQmM6PnMaQmduTma/>
         <pdfx:doi>10.1016/j.micinf.2023.105252</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:CreateDate>2024-03-16T00:10:25+05:30</xap:CreateDate>
         <xap:ModifyDate>2024-03-16T00:11:05+05:30</xap:ModifyDate>
         <xap:MetadataDate>2024-03-16T00:11:05+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:411f77e7-56e2-4287-b344-4c2d49aa58e3</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:706b3c85-483e-46a4-9c9e-2a349ea8f180</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 99, 550, 103, 560
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 107, 550, 112, 560
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 116, 550, 120, 560
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 200, 550, 203, 560
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 207, 550, 212, 560
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 269, 550, 274, 560
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 277, 550, 282, 560
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 373, 550, 377, 560
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 381, 550, 386, 560
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 468, 550, 472, 560
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 476, 550, 481, 560
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 108, 537, 112, 547
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 215, 537, 219, 547
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 223, 537, 228, 547
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 232, 539, 236, 545
       Destination: 296
      Annotation: 
       Subtype: Link
       Rect: 379, 319, 553, 326
      Annotation: 
       Subtype: Link
       Rect: 378, 197, 383, 205
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 398, 155, 402, 163
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 408, 155, 413, 163
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 340, 135, 345, 142
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 346, 135, 351, 142
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 400, 114, 405, 122
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 354, 82, 359, 90
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 104, 162, 186, 169
      Annotation: 
       Subtype: Link
       Rect: 224, 162, 288, 169
      Annotation: 
       Subtype: Link
       Rect: 37, 154, 59, 160
      Annotation: 
       Subtype: Link
       Rect: 100, 154, 151, 160
      Annotation: 
       Subtype: Link
       Rect: 177, 154, 251, 160
      Annotation: 
       Subtype: Link
       Rect: 37, 145, 106, 152
      Annotation: 
       Subtype: Link
       Rect: 153, 145, 207, 152
      Annotation: 
       Subtype: Link
       Rect: 246, 145, 288, 152
      Annotation: 
       Subtype: Link
       Rect: 37, 137, 58, 143
      Annotation: 
       Subtype: Link
       Rect: 501, 586, 529, 615
      Annotation: 
       Subtype: Link
       Rect: 324, 711, 377, 719
      Annotation: 
       Subtype: Link
       Rect: 269, 655, 421, 663
      Annotation: 
       Subtype: Link
       Rect: 37, 58, 170, 65
      Annotation: 
       Subtype: Link
       Rect: 538, 50, 557, 56
      Annotation: 
       Subtype: Link
       Rect: 37, 41, 172, 48
      Annotation: 
       Subtype: Link
       Rect: 236, 739, 358, 745
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 719, 217, 727
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 218, 719, 223, 727
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 165, 708, 169, 716
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 176, 708, 180, 716
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 135, 677, 139, 685
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 146, 677, 150, 685
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 147, 645, 152, 653
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 153, 645, 157, 653
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 251, 604, 260, 612
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 222, 583, 231, 591
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 264, 562, 273, 570
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 275, 562, 283, 570
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 264, 530, 273, 538
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 275, 530, 283, 538
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 40, 499, 49, 507
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 55, 499, 63, 507
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 40, 468, 49, 475
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 55, 468, 64, 475
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 349, 566, 370, 574
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 543, 497, 552, 505
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 499, 112, 508, 120
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 492, 81, 500, 88
       Destination: 77
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 80, 677, 89, 685
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 91, 677, 99, 685
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 229, 656, 238, 664
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 212, 593, 221, 601
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 172, 551, 264, 559
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 239, 352, 249, 360
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 251, 352, 260, 360
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 179, 227, 199, 235
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 63, 206, 82, 214
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 40, 175, 61, 183
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 228, 143, 248, 151
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 120, 70, 138, 78
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 258, 70, 277, 78
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 214, 49, 235, 57
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 374, 708, 395, 716
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 514, 698, 536, 706
       Destination: 62
      Annotation: 
       Subtype: Link
       Rect: 467, 687, 476, 695
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 462, 666, 471, 674
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 473, 666, 483, 674
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 415, 583, 424, 591
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 524, 520, 547, 528
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 450, 436, 470, 444
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 309, 405, 332, 413
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 309, 384, 329, 392
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 488, 300, 497, 308
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 510, 258, 519, 266
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 525, 258, 534, 266
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 524, 216, 533, 224
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 478, 164, 487, 172
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 489, 164, 497, 172
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 395, 143, 404, 151
       Destination: 77
    Page: 
     Label: 4
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 172, 131, 177, 139
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 178, 131, 183, 139
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 525, 131, 534, 139
       Destination: 77
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 64, 719, 73, 727
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 75, 719, 83, 727
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 37, 352, 204, 360
      Annotation: 
       Subtype: Link
       Rect: 79, 282, 209, 288
      Annotation: 
       Subtype: Link
       Rect: 198, 258, 288, 264
      Annotation: 
       Subtype: Link
       Rect: 53, 250, 90, 256
      Annotation: 
       Subtype: Link
       Rect: 73, 218, 178, 225
      Annotation: 
       Subtype: Link
       Rect: 112, 178, 248, 185
      Annotation: 
       Subtype: Link
       Rect: 112, 147, 222, 153
      Annotation: 
       Subtype: Link
       Rect: 84, 115, 195, 121
      Annotation: 
       Subtype: Link
       Rect: 535, 696, 557, 703
      Annotation: 
       Subtype: Link
       Rect: 322, 688, 411, 695
      Annotation: 
       Subtype: Link
       Rect: 511, 664, 557, 671
      Annotation: 
       Subtype: Link
       Rect: 322, 656, 415, 663
      Annotation: 
       Subtype: Link
       Rect: 353, 625, 482, 631
      Annotation: 
       Subtype: Link
       Rect: 447, 601, 557, 607
      Annotation: 
       Subtype: Link
       Rect: 322, 593, 349, 599
      Annotation: 
       Subtype: Link
       Rect: 511, 569, 557, 575
      Annotation: 
       Subtype: Link
       Rect: 322, 561, 398, 567
      Annotation: 
       Subtype: Link
       Rect: 436, 529, 557, 535
      Annotation: 
       Subtype: Link
       Rect: 322, 521, 349, 527
      Annotation: 
       Subtype: Link
       Rect: 322, 489, 460, 495
      Annotation: 
       Subtype: Link
       Rect: 535, 457, 557, 464
      Annotation: 
       Subtype: Link
       Rect: 322, 449, 448, 456
      Annotation: 
       Subtype: Link
       Rect: 381, 417, 529, 424
      Annotation: 
       Subtype: Link
       Rect: 485, 393, 557, 400
      Annotation: 
       Subtype: Link
       Rect: 322, 385, 380, 392
      Annotation: 
       Subtype: Link
       Rect: 425, 369, 557, 376
      Annotation: 
       Subtype: Link
       Rect: 322, 362, 352, 368
      Annotation: 
       Subtype: Link
       Rect: 445, 338, 557, 344
      Annotation: 
       Subtype: Link
       Rect: 322, 330, 349, 336
      Annotation: 
       Subtype: Link
       Rect: 322, 306, 444, 312
      Annotation: 
       Subtype: Link
       Rect: 485, 282, 557, 288
      Annotation: 
       Subtype: Link
       Rect: 322, 274, 369, 280
      Annotation: 
       Subtype: Link
       Rect: 511, 250, 557, 256
      Annotation: 
       Subtype: Link
       Rect: 322, 242, 413, 248
      Annotation: 
       Subtype: Link
       Rect: 349, 210, 491, 216
      Annotation: 
       Subtype: Link
       Rect: 535, 194, 557, 201
      Annotation: 
       Subtype: Link
       Rect: 322, 186, 425, 193
      Annotation: 
       Subtype: Link
       Rect: 363, 162, 500, 169
      Annotation: 
       Subtype: Link
       Rect: 416, 138, 512, 145
  Checksum: 0fa8237a
   Type: CRC32
  Checksum: 0846eddee32a8523479f1b223431791c
   Type: MD5
  Checksum: 13d1ef5f031322e4bbb9a52027852b7421c5ef3a
   Type: SHA-1
  Checksum: fb8edb6ce16574fa812f97923171ba95049a5764e273b1ea65a0369f82bfb01c
   Type: SHA-256