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SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1106 FreeObjects: 3 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Therapeutic implications for sphingolipid metabolism in metabolic dysfunction-associated steatohepatitis Destination: bmark_-1608613395 Children: Item: Title: 1 Introduction Destination: s1 Item: Title: 2 Intracellular metabolism and cellular actions of sphingolipids Destination: s2 Children: Item: Title: 2.1 Intracellular metabolism of sphingolipids Destination: s2_1 Item: Title: 2.2 Cellular actions of sphingolipids Destination: s2_2 Item: Title: 3 Alterations of sphingolipid metabolism in MASH pathogenesis Destination: s3 Item: Title: 4 Experimental/clinical evidence of therapies targeting sphingolipid metabolism and its impact on MASLD/MASH Destination: s4 Children: Item: Title: 4.1 Drugs known to act on different molecular targets involved in sphingolipid metabolism Destination: s4_1 Children: Item: Title: 4.1.1 Myriocin Destination: s4_1_1 Item: Title: 4.1.2 Fingolimod Destination: s4_1_2 Item: Title: 4.1.3 Ceramide synthase inhibitors Destination: s4_1_3 Item: Title: 4.1.4 Specific inhibitors of acid sphingomyelinase Destination: s4_1_4 Item: Title: 4.1.5 Specific inhibitors of dihydroceramide desaturase 1 Destination: s4_1_5 Item: Title: 4.1.6 Intestinal farnesoid X receptor antagonists Destination: s4_1_6 Item: Title: 4.1.7 Other approaches Destination: s4_1_7 Item: Title: 4.2 Anti-diabetics Destination: s4_2 Children: Item: Title: 4.2.1 Metformin Destination: s4_2_1 Item: Title: 4.2.2 Thiazolidinediones Destination: s4_2_2 Item: Title: 4.2.3 Glucagon-like peptide-1 receptor agonists Destination: s4_2_3 Item: Title: 4.2.4 Sodium-glucose cotransporter 2 inhibitors Destination: s4_2_4 Item: Title: 4.2.5 New antidiabetic drugs Destination: s4_2_5 Item: Title: 5 Conclusions and perspectives Destination: s5 Item: Title: Author contributions Destination: s6 Item: 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Rojo-López María Teresa Julián Núria Alonso Josep Julve Didac Mauricio Ramos-Molina B, Rossell J, Pérez-Montes de Oca A, Pardina E, Genua I, Rojo-López MI, Julián MT, Alonso N, Julve J and Mauricio D (2024) Therapeutic implications for sphingolipid metabolism in metabolic dysfunction-associated steatohepatitis. Front. Endocrinol. 15:1400961 Copyright © 2024 Ramos-Molina, Rossell, Pérez-Montes de Oca, Pardina, Genua, Rojo-López, Julián, Alonso, Julve and Mauricio. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. steatotic liver hepatic fibrosis steatohepatitis sphingolipids inflammation lipotoxicity mitochondrial dysfunction Therapeutic implications for sphingolipid metabolism in metabolic dysfunction-associated steatohepatitis steatotic liver, hepatic fibrosis, steatohepatitis, sphingolipids, inflammation, lipotoxicity, mitochondrial dysfunction True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 221, 685, 494, 706 Annotation: Subtype: Link Rect: 221, 660, 482, 681 Annotation: Subtype: Link Rect: 221, 635, 447, 656 Annotation: Subtype: Link Rect: 221, 610, 471, 631 Annotation: Subtype: Link Rect: 49, 33, 135, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 690, 125, 705 Annotation: Subtype: Link Rect: 60, 537, 118, 544 Annotation: Subtype: Link Rect: 60, 517, 144, 524 Annotation: Subtype: 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