80d249c5b91f97741df12e30b524c8b4 307618.pdf c95ab93e884be2c0ff3cdfaf51d561948636db22 307618.pdf 02d8a96f6d358ab309911b1d1ffa74987c82b2c45056c52c7c59787e894958d1 307618.pdf Title: Long-term safety of OnabotulinumtoxinA treatment in chronic migraine patients: a five-year retrospective study Subject: Background: Real-world studies have shown the sustained therapeutic effect and favourable safety profile of OnabotulinumtoxinA (BoNTA) in the long term and up to 4 years of treatment in chronic migraine (CM). Author: María Pilar Navarro-Pérez; Vicente González-Quintanilla; Albert Muñoz-Vendrell; Elisabet Madrigal; Alicia Alpuente; Germán Latorre; Francis Molina; María José Monzón; Vicente Medrano; David García-Azorín; Carmen González-Oria; Ana Gago-Veiga; Fernando Velasco; Isabel Beltrán; Noemí Morollón; Javier Viguera; Javier Casas-Limón; Jaime Rodríguez-Vico; Elisa Cuadrado; Pablo Irimia; Fernando Iglesias; Ángel Luis Guerrero-Peral; Robert Belvís; Patricia Pozo-Rosich; Julio Pascual; Sonia Santos-Lasaosa Creator: Adobe InDesign 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Mon Jun 10 19:23:02 2024 CEST ModDate: Mon Jun 10 19:23:11 2024 CEST Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 295426 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AGNKPT+MuseoSans-500 Type 1C Custom yes yes yes 8 0 YDJYNX+MuseoSans-300 Type 1C Custom yes yes yes 9 0 WVKMLB+MuseoSans-700 Type 1C Custom yes yes yes 10 0 USLAJF+MuseoSans-300Italic Type 1C WinAnsi yes yes yes 269 0 TTWUVH+MinionPro-Regular Type 1C Custom yes yes yes 11 0 QMIXFN+STIXGeneral-Regular Type 1C Custom yes yes yes 12 0 PNYRRP+MinionPro-It Type 1C Custom yes yes yes 69 0 MGKZBV+MuseoSans-500Italic Type 1C WinAnsi yes yes yes 70 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-12 02:42:56 CET RepresentationInformation: 307618.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-11 18:49:03 CET Size: 295426 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 1045 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-GB Outlines: Item: Title: Long-term safety of OnabotulinumtoxinA treatment in chronic migraine patients: a five-year retrospective study Children: Item: Title: Background Item: Title: Methods Children: Item: Title: Patients Item: Title: Data collection Item: Title: Data and statistical analysis Item: Title: Results Item: Title: Discussion Item: Title: Conclusion Item: Title: Data availability statement Item: Title: Ethics statement Item: Title: Author contributions Item: Title: References Info: Title: Long-term safety of OnabotulinumtoxinA treatment in chronic migraine patients: a five-year retrospective study Author: María Pilar Navarro-Pérez; Vicente González-Quintanilla; Albert Muñoz-Vendrell; Elisabet Madrigal; Alicia Alpuente; Germán Latorre; Francis Molina; María José Monzón; Vicente Medrano; David García-Azorín; Carmen González-Oria; Ana Gago-Veiga; Fernando Velasco; Isabel Beltrán; Noemí Morollón; Javier Viguera; Javier Casas-Limón; Jaime Rodríguez-Vico; Elisa Cuadrado; Pablo Irimia; Fernando Iglesias; Ángel Luis Guerrero-Peral; Robert Belvís; Patricia Pozo-Rosich; Julio Pascual; Sonia Santos-Lasaosa Subject: Background: Real-world studies have shown the sustained therapeutic effect and favourable safety profile of OnabotulinumtoxinA (BoNTA) in the long term and up to 4 years of treatment in chronic migraine (CM). Creator: Adobe InDesign 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Mon Jun 10 19:53:02 CEST 2024 ModDate: Mon Jun 10 19:53:11 CEST 2024 ID: 0x7670afeea1cb454e9b1028bd2fcc4dae, 0x1a14820410a051376486907381160a77 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: PNYRRP+MinionPro-It FontSubset: true FirstChar: 31 LastChar: 243 FontDescriptor: FontName: PNYRRP+MinionPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -201, -360, 1684, 1002 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MGKZBV+MuseoSans-500Italic FontSubset: true FirstChar: 112 LastChar: 112 FontDescriptor: FontName: MGKZBV+MuseoSans-500Italic Flags: Nonsymbolic FontBBox: -249, -210, 1047, 892 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: AGNKPT+MuseoSans-500 FontSubset: true FirstChar: 28 LastChar: 243 FontDescriptor: FontName: AGNKPT+MuseoSans-500 Flags: Nonsymbolic FontBBox: -121, -210, 1088, 892 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YDJYNX+MuseoSans-300 FontSubset: true FirstChar: 26 LastChar: 243 FontDescriptor: FontName: YDJYNX+MuseoSans-300 Flags: Nonsymbolic FontBBox: -118, -210, 1088, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WVKMLB+MuseoSans-700 FontSubset: true FirstChar: 29 LastChar: 121 FontDescriptor: FontName: WVKMLB+MuseoSans-700 Flags: Nonsymbolic FontBBox: -125, -210, 1126, 902 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: TTWUVH+MinionPro-Regular FontSubset: true FirstChar: 25 LastChar: 248 FontDescriptor: FontName: TTWUVH+MinionPro-Regular Flags: Serif, Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QMIXFN+STIXGeneral-Regular FontSubset: true FirstChar: 30 LastChar: 31 FontDescriptor: FontName: QMIXFN+STIXGeneral-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -443, 2000, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: USLAJF+MuseoSans-300Italic FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: USLAJF+MuseoSans-300Italic Flags: Nonsymbolic FontBBox: -245, -210, 1030, 883 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true XMP: Long-term safety of OnabotulinumtoxinA treatment in chronic migraine patients: a five-year retrospective study María Pilar Navarro-Pérez Vicente González-Quintanilla Albert Muñoz-Vendrell Elisabet Madrigal Alicia Alpuente Germán Latorre Francis Molina María José Monzón Vicente Medrano David García-Azorín Carmen González-Oria Ana Gago-Veiga Fernando Velasco Isabel Beltrán Noemí Morollón Javier Viguera Javier Casas-Limón Jaime Rodríguez-Vico Elisa Cuadrado Pablo Irimia Fernando Iglesias Ángel Luis Guerrero-Peral Robert Belvís Patricia Pozo-Rosich Julio Pascual Sonia Santos-Lasaosa Background: Real-world studies have shown the sustained therapeutic effect and favourable safety profile of OnabotulinumtoxinA (BoNTA) in the long term and up to 4 years of treatment in chronic migraine (CM). chronic migraine migraine OnabotulinumtoxinA prevention prophylaxis treatment Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 47, 808, 225, 790 Annotation: Subtype: Link Rect: 49, 41, 122, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 47, 717, 223, 699 Annotation: Subtype: Link Rect: 221, 720, 416, 696 Annotation: Subtype: Link Rect: 221, 695, 545, 671 Annotation: Subtype: Link Rect: 221, 670, 491, 646 Annotation: Subtype: Link Rect: 221, 645, 493, 621 Annotation: Subtype: Link Rect: 56, 567, 107, 560 Annotation: Subtype: Link Rect: 49, 386, 153, 378 Annotation: Subtype: Link Rect: 49, 282, 175, 274 Annotation: Subtype: Link Rect: 49, 273, 74, 265 Annotation: Subtype: Link Rect: 440, 807, 524, 800 Annotation: Subtype: Link Rect: 440, 798, 517, 791 Annotation: Subtype: Link Rect: 440, 789, 544, 782 Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 456, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 122, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 248, 534, 252, 522 ActionDest: 34 Annotation: Subtype: Link Rect: 193, 498, 197, 486 ActionDest: 34 Annotation: Subtype: Link Rect: 211, 474, 216, 462 ActionDest: 34 Annotation: Subtype: Link Rect: 246, 426, 250, 414 ActionDest: 34 Annotation: Subtype: Link Rect: 256, 426, 260, 414 ActionDest: 34 Annotation: Subtype: Link Rect: 146, 414, 151, 402 ActionDest: 34 Annotation: Subtype: Link Rect: 155, 414, 164, 402 ActionDest: 34 Annotation: Subtype: Link Rect: 128, 378, 137, 366 ActionDest: 34 Annotation: Subtype: Link Rect: 141, 378, 150, 366 ActionDest: 34 Annotation: Subtype: Link Rect: 507, 534, 512, 522 ActionDest: 34 Annotation: Subtype: Link Rect: 444, 486, 453, 474 ActionDest: 34 Annotation: Subtype: Link Rect: 453, 438, 462, 426 ActionDest: 34 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 456, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 122, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 171, 462, 195, 450 ActionDest: 30 Annotation: Subtype: Link Rect: 401, 642, 426, 630 ActionDest: 30 Annotation: Subtype: Link Rect: 462, 606, 487, 594 ActionDest: 30 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 456, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 122, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 133, 162, 142, 155 ActionDest: 34 Annotation: Subtype: Link Rect: 195, 125, 205, 118 ActionDest: 34 Annotation: Subtype: Link Rect: 276, 146, 285, 140 ActionDest: 34 Annotation: Subtype: Link Rect: 339, 141, 348, 134 ActionDest: 34 Annotation: Subtype: Link Rect: 389, 133, 399, 126 ActionDest: 34 Annotation: Subtype: Link Rect: 440, 129, 450, 123 ActionDest: 34 Annotation: Subtype: Link Rect: 467, 128, 476, 122 ActionDest: 34 Rotate: 90 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 456, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 122, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 453, 558, 461, 546 ActionDest: 34 Annotation: Subtype: Link Rect: 357, 510, 381, 498 ActionDest: 31 Annotation: Subtype: Link Rect: 307, 474, 316, 462 ActionDest: 34 Annotation: Subtype: Link Rect: 437, 414, 446, 402 ActionDest: 34 Annotation: Subtype: Link Rect: 481, 342, 490, 330 ActionDest: 34 Annotation: Subtype: Link Rect: 369, 234, 377, 222 ActionDest: 34 Annotation: Subtype: Link Rect: 457, 150, 466, 138 ActionDest: 34 Annotation: Subtype: Link Rect: 403, 126, 411, 114 ActionDest: 34 Annotation: Subtype: Link Rect: 307, 78, 316, 66 ActionDest: 34 Annotation: Subtype: Link Rect: 117, 127, 126, 120 ActionDest: 34 Annotation: Subtype: Link Rect: 180, 129, 189, 123 ActionDest: 34 Annotation: Subtype: Link Rect: 212, 129, 222, 122 ActionDest: 34 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 456, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 122, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 105, 750, 113, 738 ActionDest: 34 Annotation: Subtype: Link Rect: 71, 702, 79, 690 ActionDest: 34 Annotation: Subtype: Link Rect: 125, 630, 134, 618 ActionDest: 34 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 456, 807, 545, 800 Annotation: Subtype: Link Rect: 49, 41, 122, 33 Annotation: Subtype: Link Rect: 499, 41, 545, 33 Annotation: Subtype: Link Rect: 266, 726, 290, 717 Annotation: Subtype: Link Rect: 49, 718, 116, 709 Annotation: Subtype: Link Rect: 90, 691, 168, 682 Annotation: Subtype: Link Rect: 164, 672, 220, 663 Annotation: Subtype: Link Rect: 97, 637, 174, 628 Annotation: Subtype: Link Rect: 93, 602, 171, 593 Annotation: Subtype: Link Rect: 171, 567, 266, 558 Annotation: Subtype: Link Rect: 49, 532, 144, 523 Annotation: Subtype: Link Rect: 175, 505, 228, 496 Annotation: Subtype: Link Rect: 133, 470, 185, 461 Annotation: Subtype: Link Rect: 213, 443, 290, 434 Annotation: Subtype: Link Rect: 61, 408, 139, 399 Annotation: Subtype: Link Rect: 212, 380, 290, 371 Annotation: Subtype: Link Rect: 521, 726, 545, 717 Annotation: Subtype: Link Rect: 304, 718, 358, 709 Annotation: Subtype: Link Rect: 393, 681, 465, 672 Annotation: Subtype: Link Rect: 521, 652, 545, 643 Annotation: Subtype: Link Rect: 304, 644, 333, 635 Annotation: Subtype: Link Rect: 453, 607, 530, 598 Annotation: Subtype: Link Rect: 521, 578, 545, 569 Annotation: Subtype: Link Rect: 304, 570, 361, 561 Annotation: Subtype: Link Rect: 520, 541, 545, 532 Annotation: Subtype: Link Rect: 304, 533, 359, 524 Annotation: Subtype: Link Rect: 355, 504, 432, 495 Annotation: Subtype: Link Rect: 418, 475, 499, 466 Annotation: Subtype: Link Rect: 345, 409, 428, 400 Annotation: Subtype: Link Rect: 521, 388, 545, 379 Annotation: Subtype: Link Rect: 304, 380, 361, 371 Thumb: true Checksum: 713df1ec Type: CRC32 Checksum: 80d249c5b91f97741df12e30b524c8b4 Type: MD5 Checksum: c95ab93e884be2c0ff3cdfaf51d561948636db22 Type: SHA-1 Checksum: 02d8a96f6d358ab309911b1d1ffa74987c82b2c45056c52c7c59787e894958d1 Type: SHA-256