aa24e9e7bf1fc1ce8427e07d997c7499  307640.pdf
ac44c6f44534424d2f6612df52c8af5db090366f  307640.pdf
db36117e0b74964c157698a349da5bedb68c4f1fae027687f06813eb17e00038  307640.pdf

Creator:         Adobe InDesign 18.3 (Windows)
Producer:        Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Fri Jun 28 16:49:44 2024 CEST
ModDate:         Tue Jul  2 03:41:34 2024 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           7
Encrypted:       no
Page size:       595.276 x 793.701 pts
Page rot:        0
File size:       1826290 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Light                      Type 1C           Custom           yes no  yes     70  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes     34  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     37  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     36  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes    646  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes     35  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes    701  0
WarnockPro-It                        Type 1C           WinAnsi          yes no  yes     38  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes     41  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes     44  0
RDEISA+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes yes     68  0
WarnockPro-Semibold                  Type 1C           Custom           yes no  yes     69  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes    188  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes    189  0
BAHQCG+STIX-Regular                  Type 1C           Custom           yes yes yes    104  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-02-18 02:44:56 CET
 RepresentationInformation: 307640.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-02-17 13:54:17 CET
  Size: 1826290
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Tagged PDF
  PDFMetadata: 
   Objects: 723
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: APP dyshomeostasis in the pathogenesis of Alzheimer’s disease: implications for current drug targets
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Genetics of APP in AD
        Children: 
         Item: 
          Title: APP dysfunction in AD
         Item: 
          Title: APP-derived metabolites other than Aβ
       Item: 
        Title: Therapeutic implications
       Item: 
        Title: Future perspectives
       Item: 
        Title: Conclusions
       Item: 
        Title: References
   Info: 
    Creator: Adobe InDesign 18.3 (Windows)
    Producer: Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Fri Jun 28 16:49:44 CEST 2024
    ModDate: Tue Jul 02 03:41:34 CEST 2024
   ID: 0x780b58a842b13162bf7a7721952dbbfd, 0xb34581aac25c631bdc23cfd9e0ec2878
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1489
      ImageHeight: 1003
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 969
      ImageHeight: 1192
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     ImageMask: true
     Decode: 0, 1
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Semibold
       Flags: Serif, Nonsymbolic
       FontBBox: -181, -579, 1573, 1006
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -153, -250, 1046, 935
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -222, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: BAHQCG+STIX-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 31
      FontDescriptor: 
       FontName: BAHQCG+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: RDEISA+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 32
      FontDescriptor: 
       FontName: RDEISA+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2019/10/10-02:41:22        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:InstanceID>uuid:0d723833-37c7-4699-bb4f-96f60225d658</xmpMM:InstanceID>
         <xmpMM:OriginalDocumentID>adobe:docid:indd:aca9e6a3-b7bc-11dd-9b31-8d92eded7c31</xmpMM:OriginalDocumentID>
         <xmpMM:DocumentID>xmp.id:b3f16e4d-a8bc-ea4d-b2e6-a376bc52e2e8</xmpMM:DocumentID>
         <xmpMM:RenditionClass>proof:pdf</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:DerivedFrom rdf:parseType="Resource">
            <stRef:instanceID>xmp.iid:c6f69c12-334f-0f4e-9dba-29dc8d6603f4</stRef:instanceID>
            <stRef:documentID>xmp.did:3d9332a6-f51d-5a41-be46-ea07a84fb996</stRef:documentID>
            <stRef:renditionClass>default</stRef:renditionClass>
         </xmpMM:DerivedFrom>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:parameters>from application/x-indesign to application/pdf</stEvt:parameters>
                  <stEvt:softwareAgent>Adobe InDesign 18.3 (Windows)</stEvt:softwareAgent>
                  <stEvt:when>2024-06-28T16:49:44+02:00</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:d402abad-e4c3-4527-a2f4-51212f46fda2</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-06-28T20:30:28+02:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <xmp:CreateDate>2024-06-28T16:49:44+02:00</xmp:CreateDate>
         <xmp:ModifyDate>2024-07-02T03:41:34+02:00</xmp:ModifyDate>
         <xmp:MetadataDate>2024-07-02T03:41:34+02:00</xmp:MetadataDate>
         <xmp:CreatorTool>Adobe InDesign 18.3 (Windows)</xmp:CreatorTool>
         <prism:aggregationType>journal</prism:aggregationType>
         <crossmark:DOI>10.1186/s13195-024-01504-w</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s13195-024-01504-w</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <dc:format>application/pdf</dc:format>
         <pdf:Producer>Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>An unordered array of references to resources that were incorporated, by inclusion or reference, into this document.</pdfaProperty:description>
                           <pdfaProperty:name>Ingredients</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 415, 81, 527, 73
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 317, 73, 449, 65
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 339, 179, 344, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 426, 155, 431, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 508, 682, 540, 649
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 695, 64, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 206, 611, 210, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 59, 467, 64, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 59, 371, 64, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 122, 371, 127, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 235, 335, 240, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 59, 287, 64, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 103, 143, 108, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 122, 95, 132, 82
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 138, 95, 148, 82
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 386, 695, 396, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 128
      Annotation: 
       Subtype: Link
       Rect: 307, 671, 317, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 507, 659, 516, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 523, 623, 533, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 307, 527, 317, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 386, 455, 396, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 307, 395, 317, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 307, 215, 317, 202
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 323, 215, 333, 202
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 347, 167, 357, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 365, 167, 374, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 339, 95, 349, 82
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 240, 695, 250, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 280, 695, 285, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 105, 623, 114, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 143, 623, 148, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 129, 527, 134, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 47
      Annotation: 
       Subtype: Link
       Rect: 134, 443, 144, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 165, 407, 175, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 474, 695, 484, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 364, 635, 374, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 455, 599, 465, 586
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 523, 587, 533, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 364, 551, 374, 538
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 365, 527, 375, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 324, 467, 334, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 379, 419, 389, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 473, 395, 483, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 192, 695, 202, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 207, 695, 217, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 223, 695, 233, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 140, 635, 150, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 59, 611, 69, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 125, 575, 135, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 123, 527, 133, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 139, 527, 149, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 73, 491, 83, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 89, 491, 99, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 235, 491, 245, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 59, 455, 69, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 180, 431, 190, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 162, 395, 172, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 195, 371, 204, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 117, 359, 127, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 133, 359, 143, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 146, 335, 156, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 160, 335, 170, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 84, 287, 93, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 263, 191, 273, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 245, 71, 255, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 379, 407, 383, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 478, 263, 488, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 343, 203, 353, 190
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 368, 167, 458, 154
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 257, 323, 267, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 275, 287, 285, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 233, 203, 290, 190
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 191, 74, 178
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 482, 707, 492, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 351, 443, 361, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 427, 347, 437, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 417, 311, 427, 298
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 492, 251, 502, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 508, 251, 517, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 523, 251, 533, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 367, 227, 377, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 460, 191, 470, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 235, 503, 245, 490
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 80, 479, 90, 466
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 96, 479, 106, 466
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
     Thumb: true
    Page: 
     Sequence: 7
     Thumb: true
  Checksum: 0966b66b
   Type: CRC32
  Checksum: aa24e9e7bf1fc1ce8427e07d997c7499
   Type: MD5
  Checksum: ac44c6f44534424d2f6612df52c8af5db090366f
   Type: SHA-1
  Checksum: db36117e0b74964c157698a349da5bedb68c4f1fae027687f06813eb17e00038
   Type: SHA-256