05ddae034d857246d4e7f35fbe8300a9 jcm-13-07380.pdf 2d9fe7cabcdc815c90d018509a992c0372b08a47 jcm-13-07380.pdf 8cff42de8f315ca5300ebb88e68edfa3d5fb9fff5946f065a1f5226d4a5b8582 jcm-13-07380.pdf Title: Demographic and Clinical Characteristics of Mild, Young and Early COPD: A Cross-Sectional Analysis of 5468 Patients Subject: Early, mild and young COPD concepts are not clearly defined and are often used interchangeably to refer to the onset of the disease. Objective: To describe and compare the characteristics of mild, young and early COPD in a large sample of COPD from primary and secondary care. Methods: Pooled analysis of individual data from four multicenter observational studies of patients with stable COPD (40 years, FEV1/FVC < 0.7, smoking 10 pack-years). Mild COPD was defined as FEV1% 65%; young COPD as <55 years; and early COPD as <55 years and smoking 20 pack-years. The relationship between FEV1(%), age and pack-years was analyzed with linear regression equations. Results: We included 5468 patients. Their mean age was 67 (SD: 9.6) years, and 85% were male. A total of 1158 (21.2%) patients had mild COPD; 636 (11.6%) had young COPD and 191 (3.5%) early COPD. The three groups shared common characteristics: they were more frequently female, younger and with less tobacco exposure compared with the remaining patients. Early COPD had fewer comorbidities and fewer COPD admissions, but no significant differences were found in ambulatory exacerbations. In linear regression analysis, the decline in FEV1(%) was more pronounced for the first 20 pack-years for all age groups and was even more important in younger patients. Conclusions: Mild, young and early COPD patients were more frequently women. The steepest decline in FEV1(%) was observed in individuals <55 years and smoking between 10 and 20 pack-years (early COPD), which highlights the importance of an early detection and implementation of preventive and therapeutic measures. Keywords: COPD; young; early; mild; prognosis Author: Cristina Aljama, Cristina Esquinas, Eduardo Loeb, Galo Granados, Alexa Nuñez, Ane Lopez-Gonzalez, Marc Miravitlles and Miriam Barrecheguren Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Wed Dec 4 08:35:12 2024 CET ModDate: Wed Dec 4 08:40:14 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 741803 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OPZDHV+VnURWPalladioL Type 1 Custom yes yes yes 10 0 LWPPZU+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 NGXGOL+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 MLXHPA+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 IKKWKP+CMSY10 Type 1 Builtin yes yes yes 32 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 65 0 EGBFDN+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 86 0 EGBFDO+PalatinoLinotype CID TrueType Identity-H yes yes yes 89 0 EGBFDP+PalatinoLinotype TrueType WinAnsi yes yes no 95 0 EGBFFA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 98 0 EGBFKA+PalatinoLinotype TrueType MacRoman yes yes no 101 0 EGBFDN+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 115 0 EGBFDO+PalatinoLinotype CID TrueType Identity-H yes yes yes 118 0 EGBFDP+PalatinoLinotype TrueType WinAnsi yes yes no 124 0 EGBFFA+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 127 0 EGBFKA+PalatinoLinotype TrueType MacRoman yes yes no 130 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-17 16:57:36 CET RepresentationInformation: jcm-13-07380.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-12 11:05:45 CET Size: 741803 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 322 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Design of the Study Destination: subsection.2.1 Item: Title: Variables Destination: subsection.2.2 Item: Title: Definitions Destination: subsection.2.3 Item: Title: Statistical Analysis Destination: subsection.2.4 Item: Title: Results Destination: section.3 Children: Item: Title: Population Destination: subsection.3.1 Item: Title: Mild COPD Destination: subsection.3.2 Item: Title: Young COPD Destination: subsection.3.3 Item: Title: Early COPD Destination: subsection.3.4 Item: Title: Comparison Between Groups Classified According to Age and Smoking Intensity Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Demographic and Clinical Characteristics of Mild, Young and Early COPD: A Cross-Sectional Analysis of 5468 Patients Author: Cristina Aljama, Cristina Esquinas, Eduardo Loeb, Galo Granados, Alexa Nuñez, Ane Lopez-Gonzalez, Marc Miravitlles and Miriam Barrecheguren Subject: Early, mild and young COPD concepts are not clearly defined and are often used interchangeably to refer to the onset of the disease. Objective: To describe and compare the characteristics of mild, young and early COPD in a large sample of COPD from primary and secondary care. Methods: Pooled analysis of individual data from four multicenter observational studies of patients with stable COPD (40 years, FEV1/FVC < 0.7, smoking 10 pack-years). Mild COPD was defined as FEV1% 65%; young COPD as <55 years; and early COPD as <55 years and smoking 20 pack-years. The relationship between FEV1(%), age and pack-years was analyzed with linear regression equations. Results: We included 5468 patients. Their mean age was 67 (SD: 9.6) years, and 85% were male. A total of 1158 (21.2%) patients had mild COPD; 636 (11.6%) had young COPD and 191 (3.5%) early COPD. The three groups shared common characteristics: they were more frequently female, younger and with less tobacco exposure compared with the remaining patients. Early COPD had fewer comorbidities and fewer COPD admissions, but no significant differences were found in ambulatory exacerbations. In linear regression analysis, the decline in FEV1(%) was more pronounced for the first 20 pack-years for all age groups and was even more important in younger patients. Conclusions: Mild, young and early COPD patients were more frequently women. The steepest decline in FEV1(%) was observed in individuals <55 years and smoking between 10 and 20 pack-years (early COPD), which highlights the importance of an early detection and implementation of preventive and therapeutic measures. 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