edfb9c1be5baa4af4ad5070f190f9f1c  308061.pdf
77f3fe15d17b2223ea5f6607963fffd01525e61c  308061.pdf
56acb7f6f981406a7016dc88657c2776b61cd675a1d8aa934ce973fbe2c08a57  308061.pdf

Title:           Effect of lung volume preservation during spontaneous breathing trial on successful extubation in patients receiving mechanical ventilation: protocol for a multicenter clinical trial
Subject:         Trials, https://doi.org/10.1186/s13063-024-08297-1
Keywords:        Mechanical ventilation;Weaning;Spontaneous breathing trial;Extubation;Lung ultrasound
Author:           Carles Subirà 
Creator:         Adobe InDesign 15.1 (Windows)
Producer:        Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Fri Jul 12 14:48:15 2024 CEST
ModDate:         Tue Jul 16 12:44:10 2024 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           12
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       1202992 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     46  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes     49  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     48  0
QBYYTD+MyriadPro-Regular2            Type 1C           WinAnsi          yes yes no     303  0
MyriadPro-Light                      Type 1C           Custom           yes no  yes     47  0
QJNSCG+MyriadPro-LightIt             Type 1C           WinAnsi          yes yes yes    304  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     50  0
XNELMZ+STIX-Regular                  Type 1C           Custom           yes yes yes     51  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     52  0
WarnockPro-Light                     Type 1C           Custom           yes no  yes     67  0
MyriadPro-Regular3                   Type 1C           WinAnsi          yes no  yes    252  0
MyriadPro-SemiboldIt                 Type 1C           Custom           yes no  yes     80  0
WarnockPro-LightIt                   Type 1C           Custom           yes no  yes     96  0
WarnockPro-It                        Type 1C           Custom           yes no  yes     97  0
YVLWBX+STIXMath-Regular              Type 1C           WinAnsi          yes yes yes    131  0
AGNDDT+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes yes    183  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-02-20 02:43:33 CET
 RepresentationInformation: 308061.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-02-19 09:10:22 CET
  Size: 1202992
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 461
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Effect of lung volume preservation during spontaneous breathing trial on successful extubation in patients receiving mechanical ventilation: protocol for a multicenter clinical trial
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background 
         Item: 
          Title: Methods 
         Item: 
          Title: Discussion 
         Item: 
          Title: Trial registration 
       Item: 
        Title: Introduction
        Children: 
         Item: 
          Title: Background and rationale {6a}
         Item: 
          Title: Objectives {7}
         Item: 
          Title: Trial design {8}
       Item: 
        Title: Methods: participants, interventions, and outcomes
        Children: 
         Item: 
          Title: Study setting {9}
         Item: 
          Title: Eligibility criteria {10}
         Item: 
          Title: Who will obtain informed consent? {26a}
         Item: 
          Title: Additional consent provisions for collection and use of participant data and biological specimens {26b}
       Item: 
        Title: Interventions
        Children: 
         Item: 
          Title: Explanation of the choice of comparators {6b}
         Item: 
          Title: Description of the intervention {11a}
          Children: 
           Item: 
            Title: SBT procedure
           Item: 
            Title: Extubation procedure
           Item: 
            Title: Follow-up after extubation
           Item: 
            Title: Ultrasound monitoring
         Item: 
          Title: Criteria for discontinuing or modifying allocated interventions {11b}
         Item: 
          Title: Strategies to improve adherence to interventions {11c}
         Item: 
          Title: Relevant concomitant care permitted or prohibited during the trial {11d}
         Item: 
          Title: Provisions for post-trial care {30}
       Item: 
        Title: Outcomes {12}
        Children: 
         Item: 
          Title: Participant timeline {13}
         Item: 
          Title: Sample size {14}
         Item: 
          Title: Recruitment {15}
       Item: 
        Title: Assignment of interventions: allocation
        Children: 
         Item: 
          Title: Sequence generation {16a}
         Item: 
          Title: Concealment mechanism {16b}
         Item: 
          Title: Implementation {16c}
       Item: 
        Title: Assignment of interventions: blinding
        Children: 
         Item: 
          Title: Who will be blinded {17a}
         Item: 
          Title: Procedure for unblinding if needed {17b}
       Item: 
        Title: Data collection and management
        Children: 
         Item: 
          Title: Plans for assessment and collection of outcomes {18a}
         Item: 
          Title: Plans to promote participant retention and complete follow-up {18b}
         Item: 
          Title: Data management {19}
         Item: 
          Title: Confidentiality {27}
         Item: 
          Title: Plans for collection, laboratory evaluation, and storage of biological specimens for genetic or molecular analysis in this trialfuture use {33}
       Item: 
        Title: Statistical methods
        Children: 
         Item: 
          Title: Statistical methods for primary and secondary outcomes {20a}
         Item: 
          Title: Interim analyses {21b}
         Item: 
          Title: Methods for additional analyses (e.g., subgroup analyses) {20b}
         Item: 
          Title: Analytical methods to handle non-adherence to protocol and statistical methods to handle missing data {20c}
         Item: 
          Title: Plans to give access to the full protocol, participant-level data, and statistical code {31c}
       Item: 
        Title: Oversight and monitoring
        Children: 
         Item: 
          Title: Composition of the coordinating center and trial steering committee {5d}
         Item: 
          Title: Composition of the data monitoring committee, its role and reporting structure {21a}
         Item: 
          Title: Adverse event reporting and harms {22}
         Item: 
          Title: Frequency and plans for auditing trial conduct {23}
         Item: 
          Title: Plans for communicating important protocol amendments to relevant parties (e.g., trial participants, ethical committees) {25}
         Item: 
          Title: Dissemination plans {31a}
       Item: 
        Title: Discussion
       Item: 
        Title: Trial status
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
   Info: 
    Title: Effect of lung volume preservation during spontaneous breathing trial on successful extubation in patients receiving mechanical ventilation: protocol for a multicenter clinical trial
    Author:  Carles Subirà 
    Subject: Trials, https://doi.org/10.1186/s13063-024-08297-1
    Keywords: Mechanical ventilation;Weaning;Spontaneous breathing trial;Extubation;Lung ultrasound
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Fri Jul 12 14:48:15 CEST 2024
    ModDate: Tue Jul 16 12:44:10 CEST 2024
   ID: 0x9631d79d5e457e9cb7e34240b81c6922, 0x3b77037bac74dca73713dc01e7f0ee4c
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 115
      ImageHeight: 119
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: WarnockPro-LightIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-LightIt
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -223, -515, 1437, 929
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Light
       Flags: Serif, Nonsymbolic
       FontBBox: -175, -515, 1437, 929
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: YVLWBX+STIXMath-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 174
      FontDescriptor: 
       FontName: YVLWBX+STIXMath-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -524, 3238, 2566
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: QBYYTD+MyriadPro-Regular2
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: QBYYTD+MyriadPro-Regular2
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: QJNSCG+MyriadPro-LightIt
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: QJNSCG+MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -193, -250, 1164, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: XNELMZ+STIX-Regular
      FontSubset: true
      FirstChar: 29
      LastChar: 62
      FontDescriptor: 
       FontName: XNELMZ+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: AGNDDT+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 128
      LastChar: 128
      FontDescriptor: 
       FontName: AGNDDT+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2024-07-12T12:48:15</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.1 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2024-07-16T12:44:10+02:00</xmp:ModifyDate>
         <xmp:MetadataDate>2024-07-16T12:44:10+02:00</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>Mechanical ventilation;Weaning;Spontaneous breathing trial;Extubation;Lung ultrasound</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1186/s13063-024-08297-1</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Trials, https://doi.org/10.1186/s13063-024-08297-1</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Mechanical ventilation</rdf:li>
               <rdf:li>Weaning</rdf:li>
               <rdf:li>Spontaneous breathing trial</rdf:li>
               <rdf:li>Extubation</rdf:li>
               <rdf:li>Lung ultrasound</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Effect of lung volume preservation during spontaneous breathing trial on successful extubation in patients receiving mechanical ventilation: protocol for a multicenter clinical trial</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li> Carles Subirà </rdf:li>
               <rdf:li> Gina Rognoni </rdf:li>
               <rdf:li> Herbert Baquerizo </rdf:li>
               <rdf:li> Carolina García </rdf:li>
               <rdf:li> Sara Cabañes </rdf:li>
               <rdf:li> Maria de la Torre </rdf:li>
               <rdf:li> Beatriz Quevedo </rdf:li>
               <rdf:li> Cristina Pedrós </rdf:li>
               <rdf:li> Ana I. Tizón </rdf:li>
               <rdf:li> Natalia Murillo </rdf:li>
               <rdf:li> Laura Parro </rdf:li>
               <rdf:li> Fernando Eiras </rdf:li>
               <rdf:li> Gemma Rialp </rdf:li>
               <rdf:li> Susana Altaba </rdf:li>
               <rdf:li> Alejandro González-Castro </rdf:li>
               <rdf:li> Andrés F. Pacheco </rdf:li>
               <rdf:li> Pablo Bayoumi </rdf:li>
               <rdf:li> Norma Medrano </rdf:li>
               <rdf:li> Imma Vallverdú </rdf:li>
               <rdf:li> Áurea Higón </rdf:li>
               <rdf:li> María D. Navarro </rdf:li>
               <rdf:li> Alirio Falcón </rdf:li>
               <rdf:li> Elena Keough </rdf:li>
               <rdf:li> David Arizo </rdf:li>
               <rdf:li> Juan F. Martínez </rdf:li>
               <rdf:li> Núria Durán </rdf:li>
               <rdf:li> Raquel Rodríguez </rdf:li>
               <rdf:li> Melinda R. Popoviciu-Koborzan </rdf:li>
               <rdf:li> Isabel Guerrero </rdf:li>
               <rdf:li> Pablo Concha </rdf:li>
               <rdf:li> Patricia Barral </rdf:li>
               <rdf:li> Montserrat Batlle </rdf:li>
               <rdf:li> Sílvia Cano </rdf:li>
               <rdf:li> Silvia Garcia-Castrillon </rdf:li>
               <rdf:li> Xavier Andorrà </rdf:li>
               <rdf:li> Yenifher Tua </rdf:li>
               <rdf:li> Anna Arnau </rdf:li>
               <rdf:li> Rafael Fernández </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1186/s13063-024-08297-1</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1186/s13063-024-08297-1</prism:url>
         <prism:doi>10.1186/s13063-024-08297-1</prism:doi>
         <prism:issn>1745-6215</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Trials</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s13063-024-08297-1</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:0d102649-18e2-4334-a316-9ea23167a27b</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:d9a7012a-bbe9-4eba-afa3-eb214cad84e6</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:0d102649-18e2-4334-a316-9ea23167a27b</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2024-07-12T12:59:55Z</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name> Carles Subirà </author:name>
                  <author:orcid>http://orcid.org/0000-0003-2285-2311</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 66, 330, 58
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 486, 66, 538, 58
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 58, 270, 50
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 683, 540, 650
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 133, 534, 145, 522
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 246, 558, 251, 546
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 174, 534, 179, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 269, 462, 274, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 280, 462, 285, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 100, 426, 104, 414
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 97, 342, 101, 330
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 106, 342, 111, 330
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 264, 306, 269, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 275, 306, 285, 294
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 98, 234, 108, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 116, 234, 126, 222
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 234, 198, 244, 186
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 227, 174, 237, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 242, 174, 252, 162
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 155, 78, 165, 66
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 422, 571, 432, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 438, 571, 448, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 391, 511, 401, 498
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 458, 499, 468, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 475, 499, 485, 486
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 439, 463, 449, 450
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 392, 439, 402, 426
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 502, 427, 512, 414
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 413, 269, 423, 257
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 206, 620, 216, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 102, 499, 107, 485
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 308, 656, 313, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 511, 293, 521, 280
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 525, 293, 535, 280
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 214, 321, 219, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 105, 80, 110, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 476, 224, 486, 212
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 493, 224, 503, 212
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 334, 379, 339, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 102
      Annotation: 
       Subtype: Link
       Rect: 361, 379, 366, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 102
      Annotation: 
       Subtype: Link
       Rect: 415, 331, 425, 319
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 459, 207, 469, 194
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 367, 99, 377, 86
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
     Thumb: true
    Page: 
     Sequence: 6
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 173, 136, 182, 124
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 258, 507, 267, 495
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 275, 507, 285, 495
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 237, 447, 290, 435
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 435, 129, 423
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 504, 308, 514, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 429, 140, 439, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 189, 417, 194, 405
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 146, 535, 151, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 156, 535, 160, 522
       Flags: Print
       AppearanceDictionary: true
       Destination: 160
      Annotation: 
       Subtype: Link
       Rect: 148, 487, 158, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 163, 487, 173, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 235, 475, 245, 462
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 188, 439, 198, 426
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 122, 343, 131, 330
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 330, 633, 340, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 351, 561, 361, 548
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 392, 213, 402, 200
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 248, 631, 281, 623
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 622, 156, 614
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 360, 534, 352
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 487, 180, 533, 172
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 171, 366, 163
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 365, 135, 535, 127
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 126, 363, 118
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 155, 595, 277, 587
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 88, 532, 233, 524
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 117, 505, 266, 497
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 88, 469, 237, 461
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 253, 379, 286, 371
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 370, 167, 362
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 252, 280, 285, 272
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 271, 182, 263
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 154, 286, 146
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 242, 118, 282, 110
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 109, 246, 101
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 485, 595, 531, 587
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 586, 407, 578
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 414, 550, 532, 542
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 541, 343, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 464, 523, 536, 515
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 514, 390, 506
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 503, 478, 536, 470
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 469, 422, 461
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: d78cf215
   Type: CRC32
  Checksum: edfb9c1be5baa4af4ad5070f190f9f1c
   Type: MD5
  Checksum: 77f3fe15d17b2223ea5f6607963fffd01525e61c
   Type: SHA-1
  Checksum: 56acb7f6f981406a7016dc88657c2776b61cd675a1d8aa934ce973fbe2c08a57
   Type: SHA-256