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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz14146-supitem-0001' cannot be found ID: PDF-HUL-122 Offset: 8026764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'alz14146-supitem-0002' cannot be found ID: PDF-HUL-122 Offset: 8026764 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 695 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Characterization of white matter hyperintensities in Down syndrome Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | BACKGROUND Destination: section..1.1 Item: Title: 2 | METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Study design and participants Destination: subsection..1.2.1 Item: Title: 2.2 | Neuroimaging data Destination: subsection..1.2.2 Children: Item: Title: 2.2.1 | MRI acquisition Destination: subsubsection..1.2.2.1 Item: Title: 2.2.2 | Gray matter volume Destination: subsubsection..1.2.2.2 Item: Title: 2.2.3 | WMH segmentation Destination: subsubsection..1.2.2.3 Item: Title: 2.2.4 | White matter parcellation Destination: subsubsection..1.2.2.4 Item: Title: 2.3 | Fluid biomarkers Destination: subsection..1.2.3 Item: Title: 2.4 | Statistical analyses Destination: subsection..1.2.4 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | Population Destination: subsection..1.3.1 Item: Title: 3.2 | Associations between WMH volume and sociodemographic, clinical, and genetic data Destination: subsection..1.3.2 Item: Title: 3.3 | Spatial distribution of WMHs in DS Destination: subsection..1.3.3 Item: Title: 3.4 | Effect of AD clinical status on WMH volume Destination: subsection..1.3.4 Item: Title: 3.5 | Associations between WMH volume and CSF biomarkers Destination: subsection..1.3.5 Item: Title: 3.6 | Associations between WMH volume and GM volume Destination: subsection..1.3.6 Item: Title: 4 | DISCUSSION Destination: section..1.4 Item: Title: AUTHOR CONTRIBUTIONS Destination: section*.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.6 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.8 Children: Item: Title: DATA AVAILABILITY STATEMENT Destination: section*.10 Item: Title: CONSENT STATEMENT Destination: section*.12 Item: Title: ORCID Destination: section*.14 Item: Title: REFERENCES Destination: section*.16 Item: Title: SUPPORTING INFORMATION Destination: section*.18 Info: Title: Characterization of white matter hyperintensities in Down syndrome Author: Subject: Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Tue Sep 10 17:22:42 CEST 2024 ModDate: Tue Sep 10 17:23:14 CEST 2024 ID: 0x2ed1057d60b27009104154bb41b65de4, 0x89649106431d0340f08d7231ed1959ae Filters: FilterPipeline: FlateDecode Images: Image: 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