9674233f690064983c37dcfed62a2221 308083.pdf 0552c57d75391258936b39fe74b7425d2fb547ff 308083.pdf 5494f46f363285776909c6d69a3bb05333b93f418a8d2d9fb999a927e439cfe0 308083.pdf Title: SpadaHC: a database to improve the classification of variants in hereditary cancer genes in the Spanish population Subject: DOI: https://doi.org/10.1093/database/baae055 Database, 00, 00, 2024-07-04. Keywords: en-US Author: José M. Moreno-Cabrera Creator: LuaLaTeX with hyperref package Producer: LuaLaTeX CreationDate: Mon Jul 1 04:01:12 2024 CEST ModDate: Thu Jul 4 16:38:29 2024 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 3644204 bytes Optimized: yes PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EKFMMU+UniversLTStd-Bold CID Type 0C Identity-H yes yes yes 1639 0 XVZVYO+LMRoman10-Regular CID Type 0C Identity-H yes yes yes 1642 0 GQSBHC+UniversLTStd-Cn CID Type 0C Identity-H yes yes yes 1645 0 MKIDFK+SabonLTStd-Roman CID Type 0C Identity-H yes yes yes 1648 0 JJEHWB+UniversLTStd-Obl CID Type 0C Identity-H yes yes yes 282 0 ACMCAB+UniversLTStd CID Type 0C Identity-H yes yes yes 283 0 LUQJZV+UniversLTStd-CnObl CID Type 0C Identity-H yes yes yes 280 0 CLEUNU+UniversLTStd-Light CID Type 0C Identity-H yes yes yes 285 0 SGUTAM+SabonLTStd-Italic CID Type 0C Identity-H yes yes yes 297 0 FCPUCI+SabonLTStd-Bold CID Type 0C Identity-H yes yes yes 293 0 JVNPXQ+LatinModernMath-Regular CID Type 0C Identity-H yes yes yes 300 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-26 02:46:55 CET RepresentationInformation: 308083.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-25 19:54:42 CET Size: 3644204 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: SpadaHC: a database to improve the classification of variants in hereditary cancer genes in the Spanish population Children: Item: Title: Introduction Item: Title: Results Children: Item: Title: Available data Item: Title: Features Children: Item: Title: Open and restricted access Item: Title: Flexible dataset submission format Item: Title: Automatic identifier pseudo-anonymization Item: Title: VCF quality control Item: Title: Variant normalization Item: Title: Liftover between genome builds Item: Title: Search and explore data Item: Title: Variant classifications Item: Title: Automatic discrepancy notification Item: Title: Variant frequencies Item: Title: Variant details and individual view Item: Title: Use of SpadaHC to resolve classification discrepancies Item: Title: Discussion Children: Item: Title: Use of SpadaHC to resolve classification discrepancies Item: Title: Future directions Children: Item: Title: Beacon network Item: Title: Automated ClinVar submission Item: Title: Methods Children: Item: Title: Implementation Item: Title: Laboratory and user registration Item: Title: Dataset submission Item: Title: Allele frequency calculation Item: Title: Noisy, empty, duplicate and kinship tests Item: Title: Main transcript selection Item: Title: Use of SpadaHC to resolve classification discrepancies Children: Item: Title: First phase Item: Title: Second phase Item: Title: Third phase Item: Title: Supplementary Material Item: Title: Data Availability Item: Title: Funding Item: Title: Conflict of interest statement Item: Title: Acknowledgements Item: Title: References Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: MKIDFK+SabonLTStd-Roman Encoding: Identity-H ToUnicode: true Font: BaseFont: FCPUCI+SabonLTStd-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: EKFMMU+UniversLTStd-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: LUQJZV+UniversLTStd-CnObl Encoding: Identity-H ToUnicode: true Font: BaseFont: SGUTAM+SabonLTStd-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: XVZVYO+LMRoman10-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: JJEHWB+UniversLTStd-Obl Encoding: Identity-H ToUnicode: true Font: BaseFont: ACMCAB+UniversLTStd Encoding: Identity-H ToUnicode: true Font: BaseFont: JVNPXQ+LatinModernMath-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: GQSBHC+UniversLTStd-Cn Encoding: Identity-H ToUnicode: true Font: BaseFont: CLEUNU+UniversLTStd-Light Encoding: Identity-H ToUnicode: true CIDFontType0: Font: BaseFont: CLEUNU+UniversLTStd-Light CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: CLEUNU+UniversLTStd-Light Flags: Symbolic FontBBox: -151, -250, 1000, 957 FontFile3: true Font: BaseFont: EKFMMU+UniversLTStd-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: EKFMMU+UniversLTStd-Bold Flags: Symbolic FontBBox: -167, -250, 995, 938 FontFile3: true Font: BaseFont: LUQJZV+UniversLTStd-CnObl CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: LUQJZV+UniversLTStd-CnObl Flags: Symbolic FontBBox: -172, -270, 1064, 989 FontFile3: true Font: BaseFont: FCPUCI+SabonLTStd-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: FCPUCI+SabonLTStd-Bold Flags: Symbolic FontBBox: -163, -228, 1000, 968 FontFile3: true Font: BaseFont: XVZVYO+LMRoman10-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: XVZVYO+LMRoman10-Regular Flags: Symbolic FontBBox: -430, -290, 1417, 1127 FontFile3: true Font: BaseFont: SGUTAM+SabonLTStd-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: SGUTAM+SabonLTStd-Italic Flags: Symbolic FontBBox: -146, -228, 1059, 927 FontFile3: true Font: BaseFont: GQSBHC+UniversLTStd-Cn CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GQSBHC+UniversLTStd-Cn Flags: Symbolic FontBBox: -166, -250, 1000, 989 FontFile3: true Font: BaseFont: JVNPXQ+LatinModernMath-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JVNPXQ+LatinModernMath-Regular Flags: Symbolic FontBBox: -1042, -3060, 4082, 3560 FontFile3: true Font: BaseFont: ACMCAB+UniversLTStd CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ACMCAB+UniversLTStd Flags: Symbolic FontBBox: -168, -250, 992, 947 FontFile3: true Font: BaseFont: MKIDFK+SabonLTStd-Roman CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MKIDFK+SabonLTStd-Roman Flags: Symbolic FontBBox: -165, -228, 1000, 944 FontFile3: true Font: BaseFont: JJEHWB+UniversLTStd-Obl CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JJEHWB+UniversLTStd-Obl Flags: Symbolic FontBBox: -174, -272, 1145, 947 FontFile3: true XMP: LuaLaTeX 1.5 en-US application/pdf baae055_icore_preview.tex José M. Moreno-Cabrera Lidia Feliubadal00F3$\protect \acute {\text {o}}$ Marta Pineda Patricia Prada-Dacasa Mireia Ramos-Muntada Jesús Del Valle Joan Brunet Bernat Gel María Curr"00E1s-Freixes Bruna Calsina Milton E. Salazar-Hidalgo Marta Rodríguez-Balada Bàrbara Roig Sara Fern"00E1ndez-Castillejo Mercedes Dur"00E1n Domínguez M00F3$\protect \acute {\text {o}}$nica Arranz Ledo Mar Infante Sanz Adela Castillejo Estela D"00E1maso José L. Soto Montserrat de Miguel Beatriz Hidalgo Calero José M. S"00E1nchez-Zapardiel Teresa Ramon Y Cajal Adriana Lasa Alexandra Gisbert-Beamud Anael L00F3$\protect \acute {\text {o}}$pez-Novo Clara Ruiz-Ponte Miriam Potrony María I. Alvarez-Mora Ana Osorio Isabel Lorda-S"00E1nchez Mercedes Robledo Alberto Casc00F3$\protect \acute {\text {o}}$n Anna Ruiz Nino Spataro Imma Hernan Emma Borràs Alejandro Moles-Fern"00E1ndez Julie Earl Juan Cadiñanos Ana B. S"00E1nchez-Heras Anna Bigas Gabriel Capell"00E1 Conxi L"00E1zaro SpadaHC: a database to improve the classification of variants in hereditary cancer genes in the Spanish population SpadaHC: a database to improve the classification of variants in hereditary cancer genes in the Spanish population Text OUP Publishing DOI: https://doi.org/10.1093/database/baae055 Database, 00, 00, 2024-07-04. DOI: https://doi.org/10.1093/database/baae055 Database, 00, 00, 2024-07-04. en-US 2024-07-01T07:31:12+05:30 © The Author(s) 2024. Published by Oxford University Press. en-US LuaLaTeX with hyperref package 2024-07-01T07:31:12+05:30 2024-07-04T20:08:29+05:30 2024-07-04T20:08:29+05:30 uuid:5730787b-5738-46df-8741-a7df0618994f uuid:c9c6f121-5894-499b-974d-9e3ffaa2079c default 1 converted uuid:dcc45a26-da0b-450d-8f05-cf6d77f66a27 converted to PDF/A-3a Preflight 2024-07-04T20:08:28+05:30 three Journal 00 00 1758-0463 https://doi.org/10.1093/database/baae055 https://doi.org/https://doi.org/10.1093/database/baae055 10 True 3 A PDF/A ID Schema pdfaid http://www.aiim.org/pdfa/ns/id/ year Integer internal Year of standard internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text PDF/UA Universal Accessibility Schema pdfuaid http://www.aiim.org/pdfua/ns/id/ part Integer internal Part of ISO 14289 standard PDF/X ID Schema pdfxid http://www.npes.org/pdfx/ns/id/ GTS_PDFXVersion Text internal ID of PDF/X standard PRISM Basic Metadata prism http://prismstandard.org/namespaces/basic/3.0/ complianceProfile Text internal PRISM specification compliance profile to which this document adheres publicationName Text external Publicationname aggregationType Text external Publicationtype bookEdition Text external Edition of the book in which the document was published volume Text external Publication volume number number Text external Publication issue number within a volume pageRange Text external Page range for the document within the print version of its publication issn Text external ISSN for the printed publication in which the document was published eIssn Text external ISSN for the electronic publication in which the document was published isbn Text external ISBNforthepublicationinwhichthedocumentwaspublished doi Text external Digital Object Identifier for the document url URL external URL at which the document can be found byteCount Integer internal Approximate file size in octets pageCount Integer internal Number of pages in the print version of the document subtitle Text external Document'ssubtitle http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: url Rect: 175, 602, 187, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: ref Rect: 186, 606, 193, 615 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 193, 606, 199, 615 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 199, 606, 206, 615 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: url Rect: 298, 602, 311, 615 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: ref Rect: 310, 606, 316, 615 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 316, 606, 322, 615 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 396, 606, 402, 615 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 403, 606, 409, 615 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 525, 606, 531, 615 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 531, 606, 538, 615 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 169, 592, 175, 600 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 176, 592, 182, 600 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: url Rect: 263, 587, 275, 600 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: ref Rect: 274, 592, 281, 600 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 281, 592, 287, 600 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: url Rect: 355, 587, 367, 600 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: ref Rect: 366, 592, 372, 600 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 373, 592, 379, 600 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: url Rect: 438, 587, 451, 600 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: ref Rect: 450, 592, 456, 600 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 153, 577, 159, 585 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: url Rect: 235, 571, 248, 585 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: ref Rect: 247, 577, 253, 585 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 388, 577, 395, 585 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 525, 577, 531, 585 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 114, 562, 121, 570 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 257, 562, 264, 570 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 416, 562, 422, 570 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 530, 562, 536, 570 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 135, 548, 142, 555 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 226, 547, 232, 555 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: url Rect: 314, 541, 326, 555 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: ref Rect: 325, 547, 331, 555 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 400, 547, 406, 555 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 524, 547, 530, 555 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 163, 532, 169, 540 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 313, 532, 319, 540 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 433, 533, 443, 540 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 513, 532, 523, 540 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 523, 532, 534, 540 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 188, 518, 199, 525 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 298, 518, 308, 525 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 398, 517, 409, 525 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 409, 517, 420, 525 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 504, 517, 515, 525 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 515, 517, 526, 525 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 158, 502, 168, 510 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 168, 502, 179, 510 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 241, 502, 251, 510 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 251, 502, 262, 510 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 377, 502, 388, 510 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 388, 502, 398, 510 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: url Rect: 500, 497, 512, 510 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: ref Rect: 511, 502, 522, 510 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 522, 502, 532, 510 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 126, 487, 137, 495 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 137, 487, 147, 495 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 204, 488, 214, 495 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 288, 488, 299, 495 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 373, 488, 384, 495 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 458, 488, 469, 495 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 189, 472, 200, 480 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Contents: ref Rect: 200, 472, 211, 480 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Contents: ref Rect: 263, 472, 269, 480 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 269, 472, 280, 480 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Contents: ref Rect: 368, 473, 379, 480 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Contents: ref Rect: 496, 473, 507, 480 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Contents: ref Rect: 106, 457, 112, 465 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 112, 457, 123, 465 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Contents: ref Rect: 123, 457, 134, 465 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Contents: ref Rect: 357, 457, 364, 465 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 364, 457, 370, 465 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 370, 457, 376, 465 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Contents: ref Rect: 468, 457, 474, 465 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 474, 457, 481, 465 Flags: Print AppearanceDictionary: true Destination: 1599 Annotation: Subtype: Link Contents: ref Rect: 481, 457, 487, 465 Flags: Print AppearanceDictionary: true Destination: 1 Annotation: Subtype: Link Contents: url Rect: 387, 49, 532, 58 Flags: Print AppearanceDictionary: true Page: Label: 2 Annotations: Annotation: Subtype: Link Contents: url Rect: 200, 623, 281, 634 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: url Rect: 315, 614, 381, 623 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: url Rect: 99, 379, 202, 388 Flags: Print AppearanceDictionary: true Page: Label: 3 Annotations: Annotation: Subtype: Link Contents: ref Rect: 211, 626, 218, 637 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 218, 451, 225, 462 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 228, 451, 235, 462 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 228, 363, 235, 374 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 247, 341, 254, 352 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 211, 265, 218, 276 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 119, 254, 126, 265 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 217, 254, 224, 265 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 229, 254, 236, 265 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 91, 243, 103, 254 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 203, 243, 216, 254 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 129, 155, 136, 166 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 139, 155, 151, 166 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 504, 100, 553, 112 Flags: Print AppearanceDictionary: true Destination: 31 Annotation: Subtype: Link Contents: ref Rect: 308, 90, 357, 101 Flags: Print AppearanceDictionary: true Destination: 31 Page: Label: 4 Annotations: Annotation: Subtype: Link Contents: ref Rect: 260, 258, 272, 269 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 104, 51, 210, 62 Flags: Print AppearanceDictionary: true Destination: 31 Annotation: Subtype: Link Contents: ref Rect: 305, 652, 407, 663 Flags: Print AppearanceDictionary: true Destination: 31 Annotation: Subtype: Link Contents: ref Rect: 305, 499, 406, 510 Flags: Print AppearanceDictionary: true Destination: 31 Annotation: Subtype: Link Contents: ref Rect: 379, 309, 392, 320 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 305, 287, 407, 298 Flags: Print AppearanceDictionary: true Destination: 31 Annotation: Subtype: Link Contents: ref Rect: 318, 229, 419, 240 Flags: Print AppearanceDictionary: true Destination: 31 Page: Label: 5 Annotations: Annotation: Subtype: Link Contents: ref Rect: 174, 650, 276, 661 Flags: Print AppearanceDictionary: true Destination: 31 Annotation: Subtype: Link Contents: ref Rect: 274, 562, 286, 573 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: url Rect: 231, 551, 292, 562 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: url Rect: 47, 540, 98, 551 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: ref Rect: 161, 540, 173, 551 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 157, 529, 170, 540 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 253, 529, 265, 540 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 130, 414, 177, 425 Flags: Print AppearanceDictionary: true Destination: 22 Annotation: Subtype: Link Contents: ref Rect: 97, 392, 104, 403 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 47, 348, 94, 359 Flags: Print AppearanceDictionary: true Destination: 22 Annotation: Subtype: Link Contents: ref Rect: 272, 260, 292, 272 Flags: Print AppearanceDictionary: true Destination: 31 Annotation: Subtype: Link Contents: ref Rect: 47, 250, 131, 261 Flags: Print AppearanceDictionary: true Destination: 31 Annotation: Subtype: Link Contents: ref Rect: 521, 290, 533, 302 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 365, 82, 378, 93 Flags: Print AppearanceDictionary: true Destination: 34 Page: Label: 6 Annotations: Annotation: Subtype: Link Contents: ref Rect: 135, 127, 143, 139 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 210, 40, 222, 51 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 438, 412, 445, 423 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 490, 412, 503, 423 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 320, 401, 327, 412 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 511, 401, 523, 412 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 442, 204, 449, 215 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 452, 204, 465, 215 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 529, 192, 542, 204 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 500, 170, 512, 182 Flags: Print AppearanceDictionary: true Destination: 34 Page: Label: 7 Annotations: Annotation: Subtype: Link Contents: ref Rect: 169, 281, 181, 292 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 274, 281, 286, 292 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 121, 270, 133, 281 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 205, 270, 217, 281 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 50, 259, 62, 270 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 143, 259, 155, 270 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 226, 259, 238, 270 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 78, 248, 90, 259 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 154, 248, 166, 259 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 169, 248, 182, 259 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 259, 248, 271, 259 Flags: Print AppearanceDictionary: true Destination: 37 Annotation: Subtype: Link Contents: ref Rect: 205, 237, 217, 248 Flags: Print AppearanceDictionary: true Destination: 37 Annotation: Subtype: Link Contents: url Rect: 94, 226, 209, 237 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: url Rect: 231, 215, 292, 226 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: url Rect: 47, 204, 187, 215 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: ref Rect: 455, 213, 467, 225 Flags: Print AppearanceDictionary: true Destination: 37 Page: Label: 8 Annotations: Annotation: Subtype: Link Contents: ref Rect: 66, 434, 78, 445 Flags: Print AppearanceDictionary: true Destination: 37 Annotation: Subtype: Link Contents: ref Rect: 207, 434, 220, 445 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: ref Rect: 195, 127, 202, 139 Flags: Print AppearanceDictionary: true Destination: 34 Annotation: Subtype: Link Contents: url Rect: 302, 106, 399, 117 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: url Rect: 410, 63, 525, 74 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Contents: url Rect: 305, 41, 505, 52 Flags: Print AppearanceDictionary: true Page: Label: 9 Annotations: Annotation: Subtype: Link Contents: ref Rect: 51, 400, 60, 408 Flags: Print AppearanceDictionary: true Destination: 10 Annotation: Subtype: Link Contents: ref Rect: 51, 351, 60, 358 Flags: Print AppearanceDictionary: true Destination: 10 Annotation: Subtype: Link Contents: ref Rect: 51, 311, 60, 318 Flags: Print AppearanceDictionary: true Destination: 10 Annotation: Subtype: Link Contents: ref Rect: 51, 281, 60, 289 Flags: Print AppearanceDictionary: true Destination: 10 Annotation: Subtype: Link Contents: ref Rect: 51, 261, 60, 268 Flags: Print AppearanceDictionary: true Destination: 10 Annotation: Subtype: Link Contents: ref Rect: 51, 221, 60, 229 Flags: Print AppearanceDictionary: true Destination: 10 Annotation: Subtype: Link Contents: ref Rect: 51, 181, 60, 189 Flags: Print AppearanceDictionary: true Destination: 10 Annotation: Subtype: Link Contents: ref Rect: 51, 141, 60, 149 Flags: Print AppearanceDictionary: true Destination: 10 Annotation: Subtype: Link Contents: ref Rect: 51, 91, 60, 99 Flags: Print AppearanceDictionary: true Destination: 10 Annotation: Subtype: Link Contents: ref Rect: 47, 52, 60, 59 Flags: Print AppearanceDictionary: true Destination: 10 Annotation: Subtype: Link Contents: ref Rect: 308, 700, 321, 708 Flags: Print AppearanceDictionary: true Destination: 10 Annotation: Subtype: Link Contents: ref Rect: 308, 670, 321, 678 Flags: Print AppearanceDictionary: true Destination: 13 Annotation: Subtype: Link Contents: ref Rect: 308, 640, 321, 648 Flags: Print AppearanceDictionary: true Destination: 13 Annotation: Subtype: Link Contents: ref Rect: 308, 600, 321, 608 Flags: Print AppearanceDictionary: true Destination: 19 Annotation: Subtype: Link Contents: ref Rect: 308, 590, 321, 598 Flags: Print AppearanceDictionary: true Destination: 19 Annotation: Subtype: Link Contents: ref Rect: 308, 560, 321, 568 Flags: Print AppearanceDictionary: true Destination: 19 Annotation: Subtype: Link Contents: ref Rect: 308, 541, 321, 548 Flags: Print AppearanceDictionary: true Destination: 19 Annotation: Subtype: Link Contents: ref Rect: 308, 511, 321, 518 Flags: Print AppearanceDictionary: true Destination: 19 Annotation: Subtype: Link Contents: ref Rect: 308, 481, 321, 489 Flags: Print AppearanceDictionary: true Destination: 19 Annotation: Subtype: Link Contents: ref Rect: 308, 451, 321, 459 Flags: Print AppearanceDictionary: true Destination: 22 Annotation: Subtype: Link Contents: ref Rect: 308, 411, 321, 419 Flags: Print AppearanceDictionary: true Destination: 22 Annotation: Subtype: Link Contents: ref Rect: 308, 381, 321, 389 Flags: Print AppearanceDictionary: true Destination: 22 Annotation: Subtype: Link Contents: ref Rect: 308, 341, 321, 349 Flags: Print AppearanceDictionary: true Destination: 22 Annotation: Subtype: Link Contents: ref Rect: 308, 301, 321, 309 Flags: Print AppearanceDictionary: true Destination: 28 Annotation: Subtype: Link Contents: ref Rect: 308, 282, 321, 289 Flags: Print AppearanceDictionary: true Destination: 28 Annotation: Subtype: Link Contents: ref Rect: 308, 252, 321, 259 Flags: Print AppearanceDictionary: true Destination: 28 Annotation: Subtype: Link Contents: ref Rect: 308, 222, 321, 229 Flags: Print AppearanceDictionary: true Destination: 28 Annotation: Subtype: Link Contents: ref Rect: 308, 202, 321, 210 Flags: Print AppearanceDictionary: true Destination: 28 Annotation: Subtype: Link Contents: ref Rect: 308, 182, 321, 190 Flags: Print AppearanceDictionary: true Destination: 28 Annotation: Subtype: Link Contents: ref Rect: 308, 152, 321, 160 Flags: Print AppearanceDictionary: true Destination: 28 Annotation: Subtype: Link Contents: ref Rect: 308, 122, 321, 130 Flags: Print AppearanceDictionary: true Destination: 28 Annotation: Subtype: Link Contents: ref Rect: 308, 92, 321, 100 Flags: Print AppearanceDictionary: true Destination: 28 Annotation: Subtype: Link Contents: ref Rect: 308, 62, 321, 70 Flags: Print AppearanceDictionary: true Destination: 28 Page: Label: 10 Annotations: Annotation: Subtype: Link Contents: ref Rect: 41, 720, 54, 728 Flags: Print AppearanceDictionary: true Destination: 28 Annotation: Subtype: Link Contents: ref Rect: 41, 690, 54, 698 Flags: Print AppearanceDictionary: true Destination: 28 Annotation: Subtype: Link Contents: ref Rect: 302, 720, 316, 728 Flags: Print AppearanceDictionary: true Destination: 28 Annotation: Subtype: Link Contents: ref Rect: 302, 690, 316, 698 Flags: Print AppearanceDictionary: true Destination: 31 Annotation: Subtype: Link Contents: url Rect: 384, 50, 528, 59 Flags: Print AppearanceDictionary: true Checksum: a373ddde Type: CRC32 Checksum: 9674233f690064983c37dcfed62a2221 Type: MD5 Checksum: 0552c57d75391258936b39fe74b7425d2fb547ff Type: SHA-1 Checksum: 5494f46f363285776909c6d69a3bb05333b93f418a8d2d9fb999a927e439cfe0 Type: SHA-256