e52dd8d6b308ba88ef4d7fb820548c59 308095.pdf c7b2429594c7faf59f10704431e016ad933cee93 308095.pdf df86a630f776a07b9d9a1541bc9709d5dcf85deec1263e1e7dd99fe5415ff7b9 308095.pdf Title: Reference Ranges of 2-Dimensional Placental Biometry and 3-Dimensional Placental Volume between 11 and 14 Weeks of Gestation Subject: Objective: The purpose of this study was to provide gestational age (GA) specific reference ranges for 2-dimensional (2D) placental biometry and 3-dimensional (3D) placental volume between 11 and 14 weeks of gestation. Methods: Placental biometry including 2D and 3D variables was calculated in 1142 first-trimester singleton pregnancies with non-complicated outcome between September 2016 and February 2020. Ultrasound datasets were obtained at the time of the first-trimester ultrasound, and 2D basal plate (BP), chorionic plate (CP), placental thickness (PT), and 3D placental volume (PV) were measured following a standardized methodology. Reference ranges for each variable were calculated according to GA and crown-rump-length (CRL). Results: A total of 1142 uncomplicated pregnancies were considered for analysis. All placental measurements increased significantly between 11 and 14 weeks, especially for PT (39.64%) and PV (64.4%). Reference ranges were constructed for each 2D and 3D first-trimester placental variable using the best-fit regression model for the predicted mean and SD as a function of GA and CRL. Conclusions: Reference ranges of 2D placental biometry and 3D placental volume between 11 and 14 weeks of gestation were constructed, generating reference values. Placental biometry showed a progressive increase during the first trimester. This highlights the importance of using reference range charts according to GA. Keywords: first trimester; placental biometry; placental volume; 2-dimensional ultrasound; 3-dimensional ultrasound; preeclampsia; placental insufficiency Author: Cristina Trilla Solà, Juan Parra Roca and Elisa Llurba Olivé Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Thu Jul 18 10:21:40 2024 CEST ModDate: Thu Jul 18 12:32:25 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2833360 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MWJZGO+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 NXJFFI+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 YCQGTK+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 KCJZIB+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 FJMGBM+VnURWPalladioL Type 1 Custom yes yes yes 32 0 BXZUUH+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 VORBJF+CMSY10 Type 1 Builtin yes yes yes 68 0 CGBABB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 83 0 CGBABC+PalatinoLinotype CID TrueType Identity-H yes yes yes 86 0 CGBABD+PalatinoLinotype TrueType WinAnsi yes yes no 92 0 CGBACF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 95 0 CGBAHE+PalatinoLinotype TrueType MacRoman yes yes no 98 0 ICBUDW+URWPalladioL-BoldItal Type 1 Custom yes yes yes 105 0 CGBABB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 120 0 CGBABC+PalatinoLinotype CID TrueType Identity-H yes yes yes 123 0 CGBABD+PalatinoLinotype TrueType WinAnsi yes yes no 129 0 CGBACF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 132 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-28 02:42:57 CET RepresentationInformation: 308095.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-27 09:51:32 CET Size: 2833360 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 267 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Material and Methods Destination: section.2 Children: Item: Title: Maternal and Pregnancy Characteristics Destination: subsection.2.1 Item: Title: Placental Ultrasonography Destination: subsection.2.2 Item: Title: Statistical Analysis Destination: subsection.2.3 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: References Destination: appendix.A. Info: Title: Reference Ranges of 2-Dimensional Placental Biometry and 3-Dimensional Placental Volume between 11 and 14 Weeks of Gestation Author: Cristina Trilla Solà, Juan Parra Roca and Elisa Llurba Olivé Subject: Objective: The purpose of this study was to provide gestational age (GA) specific reference ranges for 2-dimensional (2D) placental biometry and 3-dimensional (3D) placental volume between 11 and 14 weeks of gestation. Methods: Placental biometry including 2D and 3D variables was calculated in 1142 first-trimester singleton pregnancies with non-complicated outcome between September 2016 and February 2020. Ultrasound datasets were obtained at the time of the first-trimester ultrasound, and 2D basal plate (BP), chorionic plate (CP), placental thickness (PT), and 3D placental volume (PV) were measured following a standardized methodology. Reference ranges for each variable were calculated according to GA and crown-rump-length (CRL). Results: A total of 1142 uncomplicated pregnancies were considered for analysis. All placental measurements increased significantly between 11 and 14 weeks, especially for PT (39.64%) and PV (64.4%). Reference ranges were constructed for each 2D and 3D first-trimester placental variable using the best-fit regression model for the predicted mean and SD as a function of GA and CRL. Conclusions: Reference ranges of 2D placental biometry and 3D placental volume between 11 and 14 weeks of gestation were constructed, generating reference values. Placental biometry showed a progressive increase during the first trimester. This highlights the importance of using reference range charts according to GA. Keywords: first trimester; placental biometry; placental volume; 2-dimensional ultrasound; 3-dimensional ultrasound; preeclampsia; placental insufficiency Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Thu Jul 18 10:21:40 CEST 2024 ModDate: Thu Jul 18 12:32:25 CEST 2024 ID: 0x5677c2696cd5013fcc2b26319a7e438f, 0x5677c2696cd5013fcc2b26319a7e438f Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: FJMGBM+VnURWPalladioL FontSubset: true FirstChar: 160 LastChar: 226 FontDescriptor: FontName: FJMGBM+VnURWPalladioL Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NXJFFI+URWPalladioL-Bold FontSubset: true FirstChar: 3 LastChar: 121 FontDescriptor: FontName: NXJFFI+URWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: VORBJF+CMSY10 FontSubset: true FirstChar: 0 LastChar: 14 FontDescriptor: FontName: VORBJF+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true ToUnicode: true Font: BaseFont: YCQGTK+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 241 FontDescriptor: FontName: YCQGTK+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: ICBUDW+URWPalladioL-BoldItal FontSubset: true FirstChar: 78 LastChar: 78 FontDescriptor: FontName: ICBUDW+URWPalladioL-BoldItal Flags: Symbolic FontBBox: -170, -300, 1073, 935 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: MWJZGO+VnURWPalladioL-Bold FontSubset: true FirstChar: 160 LastChar: 178 FontDescriptor: FontName: MWJZGO+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KCJZIB+URWPalladioL-Ital FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: KCJZIB+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true EncodingDictionary: Differences: true ToUnicode: true Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 117, 281, 152, 290 Annotation: Subtype: Link Rect: 34, 269, 151, 278 Annotation: Subtype: Link Rect: 34, 164, 96, 186 Annotation: Subtype: Link Rect: 125, 90, 154, 99 Annotation: Subtype: Link Rect: 34, 78, 149, 87 Annotation: Subtype: Link Rect: 34, 757, 167, 793 Annotation: Subtype: Link Rect: 515, 757, 560, 793 Annotation: Subtype: Link Rect: 147, 645, 158, 658 Annotation: Subtype: Link Rect: 372, 645, 383, 658 Annotation: Subtype: Link Rect: 462, 256, 468, 265 ActionDest: 143 Annotation: Subtype: Link Rect: 469, 256, 476, 265 ActionDest: 143 Annotation: Subtype: Link Rect: 438, 218, 445, 227 ActionDest: 143 Annotation: Subtype: Link Rect: 507, 206, 514, 215 ActionDest: 143 Annotation: Subtype: Link Rect: 514, 205, 521, 215 ActionDest: 143 Annotation: Subtype: Link Rect: 212, 168, 219, 177 ActionDest: 143 Annotation: Subtype: Link Rect: 246, 130, 253, 139 ActionDest: 143 Annotation: Subtype: Link Rect: 253, 130, 260, 139 ActionDest: 143 Annotation: Subtype: Link Rect: 487, 67, 494, 76 ActionDest: 143 Annotation: Subtype: Link Rect: 495, 67, 507, 76 ActionDest: 143 Annotation: Subtype: Link Rect: 126, 17, 291, 28 Annotation: Subtype: Link Rect: 396, 17, 560, 28 Annotation: Subtype: Link Rect: 34, 354, 87, 373 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 324, 718, 336, 727 ActionDest: 143 Annotation: Subtype: Link Rect: 199, 693, 211, 702 ActionDest: 143 Annotation: Subtype: Link Rect: 214, 693, 226, 702 ActionDest: 143 Annotation: Subtype: Link Rect: 200, 655, 212, 665 ActionDest: 143 Annotation: Subtype: Link Rect: 215, 656, 227, 665 ActionDest: 146 Annotation: Subtype: Link Rect: 430, 643, 442, 652 ActionDest: 143 Annotation: Subtype: Link Rect: 440, 630, 452, 639 ActionDest: 143 Annotation: Subtype: Link Rect: 453, 593, 465, 602 ActionDest: 146 Annotation: Subtype: Link Rect: 465, 593, 477, 602 ActionDest: 146 Annotation: Subtype: Link Rect: 397, 530, 409, 539 ActionDest: 146 Annotation: Subtype: Link Rect: 409, 530, 421, 539 ActionDest: 146 Annotation: Subtype: Link Rect: 234, 188, 313, 200 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 290, 565, 302, 574 ActionDest: 146 Annotation: Subtype: Link Rect: 466, 539, 478, 549 ActionDest: 146 Annotation: Subtype: Link Rect: 478, 540, 490, 549 ActionDest: 146 Annotation: Subtype: Link Rect: 216, 349, 223, 361 ActionDest: 73 Annotation: Subtype: Link Rect: 543, 326, 555, 335 ActionDest: 146 Annotation: Subtype: Link Rect: 448, 238, 460, 247 ActionDest: 146 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 469, 181, 475, 193 ActionDest: 102 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 303, 250, 310, 262 ActionDest: 102 Annotation: Subtype: Link Rect: 345, 250, 352, 262 ActionDest: 110 Annotation: Subtype: Link Rect: 300, 225, 307, 237 ActionDest: 137 Page: Sequence: 6 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 528, 318, 540, 328 ActionDest: 146 Annotation: Subtype: Link Rect: 543, 319, 555, 328 ActionDest: 146 Annotation: Subtype: Link Rect: 442, 281, 454, 290 ActionDest: 146 Annotation: Subtype: Link Rect: 316, 206, 328, 215 ActionDest: 146 Annotation: Subtype: Link Rect: 510, 143, 522, 152 ActionDest: 146 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 223, 656, 235, 665 ActionDest: 146 Annotation: Subtype: Link Rect: 310, 580, 321, 589 ActionDest: 146 Annotation: Subtype: Link Rect: 286, 455, 297, 464 ActionDest: 146 Annotation: Subtype: Link Rect: 298, 455, 310, 464 ActionDest: 146 Annotation: Subtype: Link Rect: 290, 279, 302, 288 ActionDest: 146 Annotation: Subtype: Link Rect: 536, 140, 560, 151 Annotation: Subtype: Link Rect: 165, 128, 402, 139 Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 99, 423, 137, 434 Annotation: Subtype: Link Rect: 143, 423, 179, 434 Annotation: Subtype: Link Rect: 235, 388, 273, 399 Annotation: Subtype: Link Rect: 279, 388, 315, 399 Annotation: Subtype: Link Rect: 471, 377, 508, 388 Annotation: Subtype: Link Rect: 514, 377, 551, 388 Annotation: Subtype: Link Rect: 431, 365, 469, 376 Annotation: Subtype: Link Rect: 475, 365, 511, 376 Annotation: Subtype: Link Rect: 440, 354, 478, 365 Annotation: Subtype: Link Rect: 59, 331, 96, 342 Annotation: Subtype: Link Rect: 102, 331, 138, 342 Annotation: Subtype: Link Rect: 231, 308, 268, 319 Annotation: Subtype: Link Rect: 275, 308, 311, 319 Annotation: Subtype: Link Rect: 361, 285, 398, 296 Annotation: Subtype: Link Rect: 405, 285, 441, 296 Annotation: Subtype: Link Rect: 105, 262, 142, 273 Annotation: Subtype: Link Rect: 364, 239, 401, 250 Annotation: Subtype: Link Rect: 202, 215, 240, 227 Annotation: Subtype: Link Rect: 246, 215, 282, 227 Annotation: Subtype: Link Rect: 203, 192, 239, 203 Annotation: Subtype: Link Rect: 279, 169, 317, 180 Annotation: Subtype: Link Rect: 323, 169, 359, 180 Annotation: Subtype: Link Rect: 519, 146, 557, 157 Annotation: Subtype: Link Rect: 59, 136, 95, 146 Annotation: Subtype: Link Rect: 360, 100, 397, 111 Annotation: Subtype: Link Rect: 404, 100, 440, 111 Annotation: Subtype: Link Rect: 212, 67, 250, 77 Annotation: Subtype: Link Rect: 256, 67, 292, 77 Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 298, 730, 334, 741 Annotation: Subtype: Link Rect: 519, 718, 557, 729 Annotation: Subtype: Link Rect: 59, 707, 95, 718 Annotation: Subtype: Link Rect: 282, 672, 320, 683 Annotation: Subtype: Link Rect: 295, 649, 332, 660 Annotation: Subtype: Link Rect: 339, 649, 375, 660 Annotation: Subtype: Link Rect: 285, 626, 322, 637 Annotation: Subtype: Link Rect: 328, 626, 365, 637 Annotation: Subtype: Link Rect: 335, 603, 372, 614 Annotation: Subtype: Link Rect: 379, 603, 415, 614 Annotation: Subtype: Link Rect: 59, 581, 96, 591 Annotation: Subtype: Link Rect: 102, 581, 138, 591 Annotation: Subtype: Link Rect: 118, 546, 155, 556 Annotation: Subtype: Link Rect: 161, 546, 197, 556 Annotation: Subtype: Link Rect: 457, 522, 495, 533 Annotation: Subtype: Link Rect: 501, 522, 537, 533 Annotation: Subtype: Link Rect: 387, 499, 425, 510 Annotation: Subtype: Link Rect: 431, 499, 467, 510 Annotation: Subtype: Link Rect: 59, 477, 95, 487 Annotation: Subtype: Link Rect: 257, 453, 294, 464 Annotation: Subtype: Link Rect: 300, 453, 336, 464 Annotation: Subtype: Link Rect: 447, 442, 484, 453 Checksum: ed09a64f Type: CRC32 Checksum: e52dd8d6b308ba88ef4d7fb820548c59 Type: MD5 Checksum: c7b2429594c7faf59f10704431e016ad933cee93 Type: SHA-1 Checksum: df86a630f776a07b9d9a1541bc9709d5dcf85deec1263e1e7dd99fe5415ff7b9 Type: SHA-256