23ee417bba67adaf5860062b0cdc1f47 applsci-14-10741-v3.pdf 60510a604413ad54a82bfba3401afb426d4111ba applsci-14-10741-v3.pdf ee919515226a3b47bc6c8f4241da9f5036bf275cf660e83f1882785341d42018 applsci-14-10741-v3.pdf Title: Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices Subject: The implantation of materials into in vivo peripheral nerves triggers the production of scar tissue. A scar capsule progressively incorporates foreign bodies, which become insulated from the surrounding environment. This phenomenon is particularly detrimental in the case of electrical active sites enveloped within scar sheets, since the loss of contact with axons highly decreases the effectiveness of neural interfaces. As a consequence, the in silico modelling of scar capsule evolution may lead to improvements in the design of intraneural structures and enhancing their reliability over time. In this work, a novel theoretical framework is proposed to model the evolution of capsule thickness over time together with an improved optimisation procedure able to avoid apparently suitable choices resulting from standard procedures. This framework provides a fast, simple, and accurate modelling of experimental data (R2 = 0.97), definitely improving on previous approaches. Keywords: neural implants; foreign body reaction; scar tissue; peripheral nerves Author: Pier Nicola Sergi, Jaume del Valle, Thomas Stieglitz, Xavier Navarro and Silvestro Micera Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Tue Nov 26 03:46:42 2024 CET ModDate: Tue Nov 26 04:06:29 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 23 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 3084001 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MRZBKW+URWPalladioL-Bold Type 1 Custom yes yes yes 10 0 COGBBN+URWPalladioL-Roma Type 1 Custom yes yes yes 16 0 WZCIST+URWPalladioL-Ital Type 1 Custom yes yes yes 21 0 SOSTRQ+CMR10 Type 1 Builtin yes yes yes 26 0 CRVMKC+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 44 0 OVNEXW+EURM10 Type 1 Builtin yes 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SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Methods Destination: section.2 Item: Title: Results Destination: section.3 Children: Item: Title: A Standard Approach to Discriminate Suitable Candidate Functions Destination: subsection.3.1 Item: Title: Standard and Not Standard Analysis of Different Families of Candidate Functions Destination: subsection.3.2 Item: Title: A Novel Metric to Discriminate Compatible Functional Forms Destination: subsection.3.3 Item: Title: Sensitivity Analysis of the Best Functional Form Destination: subsection.3.4 Item: Title: Optimisation of Parameters of the Best Functional Form Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Children: Item: Title: Some Restrictions Due to the Low Cardinality of the Experimental Set Destination: subsection.4.1 Item: Title: The Standard Optimisation Process Destination: subsection.4.2 Item: Title: The Standard Validation of Potentially Suitable Candidate Functions Destination: subsection.4.3 Item: Title: Further Validation of Potentially Suitable Candidate Functions Destination: subsection.4.4 Item: Title: The Novel Metric Destination: subsection.4.5 Item: Title: Sensitivity and Optimisation of the Best Candidate Function Destination: subsection.4.6 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices Author: Pier Nicola Sergi, Jaume del Valle, Thomas Stieglitz, Xavier Navarro and Silvestro Micera Subject: The implantation of materials into in vivo peripheral nerves triggers the production of scar tissue. A scar capsule progressively incorporates foreign bodies, which become insulated from the surrounding environment. This phenomenon is particularly detrimental in the case of electrical active sites enveloped within scar sheets, since the loss of contact with axons highly decreases the effectiveness of neural interfaces. As a consequence, the in silico modelling of scar capsule evolution may lead to improvements in the design of intraneural structures and enhancing their reliability over time. In this work, a novel theoretical framework is proposed to model the evolution of capsule thickness over time together with an improved optimisation procedure able to avoid apparently suitable choices resulting from standard procedures. This framework provides a fast, simple, and accurate modelling of experimental data (R2 = 0.97), definitely improving on previous approaches. 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