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Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Materials and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Preliminary study: test cage assessment Destination: mk:H2_1 Item: Title: 2.2 Chronic exposure test Destination: mk:H2_2 Item: Title: 2.3 Osmia bees and test conditions Destination: mk:H2_3 Children: Item: Title: 2.3.1 Test procedure and experimental cages Destination: mk:H3_4 Item: Title: 2.3.2 Flupyradifurone and dimethoate concentrations and feeding solution Destination: mk:H3_5 Item: Title: 2.4 Statistical analysis Destination: mk:H2_6 Children: Item: Title: 2.4.1 Survival Destination: mk:H3_7 Item: Title: 2.4.2 Calculation of median lethal daily dose at 10 days Destination: mk:H3_8 Item: Title: 2.4.3 Syrup consumption Destination: mk:H3_9 Item: Title: 2.4.4 Time reinforced toxicity Destination: mk:H3_10 Item: Title: 2.4.5 Potential risk of O. bicornis under field conditions Destination: mk:H3_11 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 Survival curves and median lethal daily dose 50 (LDD50) Destination: mk:H2_12 Item: Title: 3.2 Syrup consumption Destination: mk:H2_13 Item: Title: 3.3 Time reinforced toxicity Destination: mk:H2_14 Item: Title: 3.4 Potential risk of O. bicornis under field conditions Destination: mk:H2_15 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: CRediT authorship contribution statement Destination: mk:H1_5 Item: Title: Disclaimer Destination: mk:H1_6 Item: Title: Declaration of competing interest Destination: mk:HH1_3 Item: Title: Acknowledgments Destination: mk:HH1_4 Item: Title: Appendix A Supplementary data Destination: mk:H1_7 Item: Title: datalink5 Destination: datalink5 Item: Title: References Destination: mk:HH2_1 Info: Title: Chronic oral toxicity protocol for adult solitary bees ( Osmia bicornis L.): Reduced survival under long-term exposure to a “bee-safe” insecticide Author: Celeste Azpiazu Subject: Environmental Pollution, 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