691ceed1ce06e4f5651258bd363778d9 1-s2.0-S0024320524008373-main.pdf 76bc83d2a6bce3c503e82ddbfaa8415ab0f69385 1-s2.0-S0024320524008373-main.pdf 996531adebeafecfddc40ba5bee10eff2bdee2f8b4be4d197f873b85a44f0249 1-s2.0-S0024320524008373-main.pdf Title: Transient cerebral ischaemia alters mesenteric arteries in hypertensive rats: Limited reversal despite suberoylanilide hydroxamic acid cerebroprotection Subject: Life Sciences, 359 (2024) 123247. doi:10.1016/j.lfs.2024.123247 Keywords: Stroke,Vasoconstriction,Vascular remodelling,Peripheral vessels,Vorinostat,Cerebroprotection Author: Andrea Díaz-Pérez Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Nov 28 23:27:22 2024 CET ModDate: Fri Nov 29 15:42:45 2024 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 9008047 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OPDMSC+CharisSIL CID TrueType Identity-H yes yes yes 1656 0 GDNPIM+CharisSIL CID TrueType Identity-H yes yes yes 1662 0 GGWFKH+CharisSIL-Bold CID TrueType Identity-H yes yes yes 1667 0 DYDQNN+Univers Type 1C Builtin yes yes yes 1672 0 NRGEBM+STIX-Italic Type 1C Custom yes yes yes 1676 0 OUTUKK+TeX_CM_Roman Type 1C Builtin yes yes yes 1681 0 AAAYGD+CharisSIL CID TrueType Identity-H yes yes yes 1685 0 DNXXBM+CharisSIL-Italic CID TrueType Identity-H yes yes yes 1693 0 AAAABE+CharisSIL-Italic CID TrueType Identity-H yes yes yes 426 0 XQTKOW+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 433 0 TUJHMV+STIX-Regular Type 1C Custom yes yes yes 438 0 AAAAAD+CharisSIL CID TrueType Identity-H yes yes yes 443 0 RBCTHC+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 450 0 JWNWSN+CharisSIL-Italic CID TrueType Identity-H yes yes yes 454 0 NTMBZO+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 461 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-03-05 02:45:36 CET RepresentationInformation: 1-s2.0-S0024320524008373-main.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-03-04 13:43:50 CET Size: 9008047 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1778 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: English Outlines: Item: Title: Transient cerebral ischaemia alters mesenteric arteries in hypertensive rats: Limited reversal despite suberoylanilide hydr ... Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Material and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Animals Destination: mk:H2_1 Item: Title: 2.2 Experimental design Destination: mk:H2_2 Item: Title: 2.3 Blood pressure measurements Destination: mk:H2_3 Item: Title: 2.4 Induction of transient middle cerebral artery occlusion (tMCAO) Destination: mk:H2_4 Item: Title: 2.5 Magnetic resonance imaging (MRI) Destination: mk:H2_5 Item: Title: 2.6 Neurological outcomes Destination: mk:H2_6 Item: Title: 2.7 Tissue preparation Destination: mk:H2_7 Item: Title: 2.8 Pressure myography Destination: mk:H2_8 Item: Title: 2.9 Nuclei distribution Destination: mk:H2_9 Item: Title: 2.10 Collagen content Destination: mk:H2_10 Item: Title: 2.11 Oxidative stress measurements Destination: mk:H2_11 Item: Title: 2.12 Statistical analysis Destination: mk:H2_12 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 Cerebral I/R impairs U46619-induced contractions in MRAs, unaffected by SAHA treatment Destination: mk:H2_13 Item: Title: 3.2 Cerebral I/R induces MRA remodelling: protective effects of SAHA treatment Destination: mk:H2_14 Item: Title: 3.3 Cerebral I/R leads to an increase in MRA media volume and collagen deposition, which is prevented by SAHA treatment Destination: mk:H2_15 Item: Title: 3.4 Cerebral I/R induces an increase in both circulating and MRA oxidative stress levels that are reduced by SAHA treatment Destination: mk:H2_16 Item: Title: 3.5 SAHA treatment exerts sustained cerebroprotection Destination: mk:H2_17 Item: Title: 3.6 Persistence of cerebral I/R-induced functional and structural alterations in MRAs: minor influence of SAHA treatment Destination: mk:H2_18 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: Ethics approval and informed consent Destination: mk:H1_5 Item: Title: Funding Destination: mk:H1_6 Item: Title: CRediT authorship contribution statement Destination: mk:H1_7 Item: Title: Declaration of competing interest Destination: mk:HH1_2 Item: Title: Acknowledgments Destination: mk:HH1_3 Item: Title: datalink4 Destination: datalink4 Item: Title: References Destination: mk:HH2_1 Info: Title: Transient cerebral ischaemia alters mesenteric arteries in hypertensive rats: Limited reversal despite suberoylanilide hydroxamic acid cerebroprotection Author: Andrea Díaz-Pérez Subject: Life Sciences, 359 (2024) 123247. doi:10.1016/j.lfs.2024.123247 Keywords: Stroke,Vasoconstriction,Vascular remodelling,Peripheral vessels,Vorinostat,Cerebroprotection Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Nov 28 23:27:22 CET 2024 ModDate: Fri Nov 29 15:42:45 CET 2024 ID: 0x5764305402d561cb0b7e2bf9df88330a, 0xb2278ece33f304d4d8f66bc1371d9dff Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: XQTKOW+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: GGWFKH+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: AAAYGD+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: JWNWSN+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: OPDMSC+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: AAAABE+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: AAAAAD+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: DNXXBM+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: GDNPIM+CharisSIL Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: OUTUKK+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: OUTUKK+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: RBCTHC+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: RBCTHC+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: TUJHMV+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 12 FontDescriptor: FontName: TUJHMV+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: DYDQNN+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: DYDQNN+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NRGEBM+STIX-Italic FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: NRGEBM+STIX-Italic Flags: Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NTMBZO+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: NTMBZO+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: GDNPIM+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GDNPIM+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: XQTKOW+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: XQTKOW+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: GGWFKH+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GGWFKH+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Font: BaseFont: AAAYGD+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AAAYGD+CharisSIL Flags: Symbolic FontBBox: -692, -533, 1623, 1318 FontFile2: true Font: BaseFont: JWNWSN+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JWNWSN+CharisSIL-Italic Flags: Serif, Symbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: OPDMSC+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: OPDMSC+CharisSIL Flags: Serif, Symbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: AAAABE+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AAAABE+CharisSIL-Italic Flags: Symbolic, Italic FontBBox: -716, -533, 1626, 1317 FontFile2: true Font: BaseFont: AAAAAD+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AAAAAD+CharisSIL Flags: Symbolic FontBBox: -692, -533, 1623, 1318 FontFile2: true Font: BaseFont: DNXXBM+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: DNXXBM+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true XMP: http://creativecommons.org/licenses/by/4.0/ elsevier.com sciencedirect.com true 10.1016/j.lfs.2024.123247 2010-04-23 application/pdf 10.1016/j.lfs.2024.123247 Elsevier Inc. Life Sciences, 359 (2024) 123247. doi:10.1016/j.lfs.2024.123247 Stroke Vasoconstriction Vascular remodelling Peripheral vessels Vorinostat Cerebroprotection Transient cerebral ischaemia alters mesenteric arteries in hypertensive rats: Limited reversal despite suberoylanilide hydroxamic acid cerebroprotection Andrea Díaz-Pérez Silvia Lope-Piedrafita Belén Pérez Paula Vázquez-Sufuentes Maria Rodriguez-Garcia Ana M. Briones Xavier Navarro Clara Penas Francesc Jiménez-Altayó VoR 29th November 2024 Acrobat Distiller 8.1.0 (Windows) Stroke,Vasoconstriction,Vascular remodelling,Peripheral vessels,Vorinostat,Cerebroprotection 29th November 2024 sciencedirect.com elsevier.com true 2010-04-23 10.1016/j.lfs.2024.123247 noindex journal © 2024 The Authors. Published by Elsevier Inc. 2024-12-15 15 December 2024 10.1016/j.lfs.2024.123247 0024-3205 123247 Life Sciences 123247 https://doi.org/10.1016/j.lfs.2024.123247 359 https://www.elsevier.com/tdm/tdmrep-policy.json 1 2024-11-28T22:27:22 Elsevier 2024-11-29T14:42:45 2024-11-29T14:42:45 uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 True Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 126, 576, 130, 587 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 132, 576, 137, 587 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 139, 576, 143, 587 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 252, 576, 257, 587 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 259, 576, 263, 587 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 266, 576, 268, 587 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 332, 576, 336, 587 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 338, 576, 343, 587 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 155, 563, 159, 574 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 162, 563, 166, 574 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 169, 563, 173, 574 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 293, 563, 297, 574 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 376, 563, 381, 574 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 383, 563, 386, 574 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 465, 563, 469, 574 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 472, 563, 475, 574 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 478, 563, 480, 574 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 94, 550, 98, 561 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 101, 550, 104, 561 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 107, 550, 109, 561 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 234, 550, 238, 561 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 241, 550, 245, 561 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 248, 550, 252, 561 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 255, 550, 259, 561 Flags: Print Destination: 1647 Annotation: Subtype: Link Rect: 107, 158, 112, 166 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 114, 158, 119, 166 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 547, 168, 552, 176 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 98, 104, 180, 111 Flags: Print Annotation: Subtype: Link Rect: 321, 722, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 274, 667, 397, 675 Flags: Print Annotation: Subtype: Link Rect: 37, 87, 174, 94 Flags: Print Annotation: Subtype: Link Rect: 244, 748, 349, 760 Annotation: Subtype: Link Rect: 501, 616, 529, 644 Annotation: Subtype: Link Rect: 405, 59, 552, 70 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 74, 709, 79, 717 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 278, 678, 283, 686 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 220, 657, 224, 665 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 188, 626, 193, 634 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 191, 584, 195, 592 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 197, 584, 202, 592 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 148, 563, 157, 571 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 159, 563, 168, 571 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 86, 542, 95, 550 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 180, 511, 189, 519 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 80, 469, 89, 477 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 58, 406, 62, 414 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 143, 375, 152, 383 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 154, 375, 163, 383 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 202, 343, 206, 351 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 209, 343, 218, 351 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 220, 343, 229, 351 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 262, 333, 271, 341 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 274, 333, 283, 341 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 88, 291, 97, 299 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 99, 291, 108, 299 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 133, 260, 142, 268 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 218, 176, 240, 184 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 274, 155, 283, 163 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 125, 103, 134, 111 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 543, 469, 552, 477 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 447, 281, 456, 289 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 445, 260, 454, 268 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 456, 260, 465, 268 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 408, 176, 428, 184 Flags: Print Destination: 35 Annotation: Subtype: Link Rect: 414, 134, 423, 142 Flags: Print Destination: 248 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 40, 447, 49, 455 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 166, 301, 175, 309 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 178, 301, 187, 309 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 40, 175, 49, 183 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 117, 144, 136, 152 Flags: Print Destination: 35 Annotation: Subtype: Link Rect: 345, 479, 354, 487 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 538, 406, 547, 414 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 345, 228, 355, 236 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 405, 165, 414, 173 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 393, 144, 402, 152 Flags: Print Destination: 248 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 232, 657, 241, 665 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 157, 647, 178, 655 Flags: Print Destination: 35 Annotation: Subtype: Link Rect: 217, 563, 226, 571 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 120, 542, 129, 550 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 123, 500, 143, 508 Flags: Print Destination: 35 Annotation: Subtype: Link Rect: 246, 479, 255, 487 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 62, 238, 70, 246 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 258, 165, 267, 173 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 174, 50, 183, 58 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 309, 657, 318, 665 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 367, 500, 376, 508 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 378, 500, 387, 508 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 389, 500, 398, 508 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 349, 469, 358, 477 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 412, 437, 421, 445 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 505, 301, 525, 309 Flags: Print Destination: 141 Annotation: Subtype: Link Rect: 392, 92, 401, 100 Flags: Print Destination: 248 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 40, 689, 59, 696 Flags: Print Destination: 69 Annotation: Subtype: Link Rect: 200, 678, 220, 686 Flags: Print Destination: 69 Annotation: Subtype: Link Rect: 40, 581, 60, 589 Flags: Print Destination: 86 Annotation: Subtype: Link Rect: 185, 571, 206, 579 Flags: Print Destination: 86 Annotation: Subtype: Link Rect: 260, 571, 280, 579 Flags: Print Destination: 86 Annotation: Subtype: Link Rect: 173, 540, 193, 548 Flags: Print Destination: 86 Annotation: Subtype: Link Rect: 105, 519, 125, 527 Flags: Print Destination: 86 Annotation: Subtype: Link Rect: 345, 689, 366, 696 Flags: Print Destination: 98 Annotation: Subtype: Link Rect: 457, 689, 478, 696 Flags: Print Destination: 98 Annotation: Subtype: Link Rect: 331, 678, 353, 686 Flags: Print Destination: 98 Annotation: Subtype: Link Rect: 408, 657, 429, 665 Flags: Print Destination: 98 Annotation: Subtype: Link Rect: 486, 647, 507, 655 Flags: Print Destination: 98 Annotation: Subtype: Link Rect: 526, 615, 547, 623 Flags: Print Destination: 98 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 149, 240, 172, 248 Flags: Print Destination: 102 Annotation: Subtype: Link Rect: 64, 209, 84, 217 Flags: Print Destination: 102 Annotation: Subtype: Link Rect: 158, 188, 180, 196 Flags: Print Destination: 102 Annotation: Subtype: Link Rect: 70, 135, 90, 143 Flags: Print Destination: 102 Annotation: Subtype: Link Rect: 385, 198, 404, 206 Flags: Print Destination: 106 Annotation: Subtype: Link Rect: 477, 188, 498, 196 Flags: Print Destination: 106 Annotation: Subtype: Link Rect: 479, 156, 499, 164 Flags: Print Destination: 106 Annotation: Subtype: Link Rect: 526, 135, 547, 143 Flags: Print Destination: 106 Page: Label: 7 Page: Label: 8 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 249, 163, 275, 171 Flags: Print Destination: 117 Annotation: Subtype: Link Rect: 206, 59, 215, 67 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 351, 205, 377, 213 Flags: Print Destination: 117 Annotation: Subtype: Link Rect: 378, 174, 399, 182 Flags: Print Destination: 141 Annotation: Subtype: Link Rect: 309, 142, 330, 150 Flags: Print Destination: 141 Annotation: Subtype: Link Rect: 502, 132, 523, 140 Flags: Print Destination: 141 Annotation: Subtype: Link Rect: 437, 69, 458, 77 Flags: Print Destination: 141 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 40, 525, 60, 533 Flags: Print Destination: 141 Annotation: Subtype: Link Rect: 212, 504, 232, 512 Flags: Print Destination: 141 Annotation: Subtype: Link Rect: 274, 494, 283, 502 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 127, 473, 147, 481 Flags: Print Destination: 141 Annotation: Subtype: Link Rect: 202, 354, 223, 362 Flags: Print Destination: 148 Annotation: Subtype: Link Rect: 132, 323, 152, 331 Flags: Print Destination: 148 Annotation: Subtype: Link Rect: 158, 281, 180, 289 Flags: Print Destination: 173 Annotation: Subtype: Link Rect: 225, 270, 244, 278 Flags: Print Destination: 173 Annotation: Subtype: Link Rect: 234, 249, 254, 257 Flags: Print Destination: 173 Annotation: Subtype: Link Rect: 128, 133, 132, 141 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 397, 605, 406, 613 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 408, 605, 417, 613 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 420, 605, 429, 613 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 416, 573, 425, 581 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 473, 511, 482, 519 Flags: Print Destination: 178 Annotation: Subtype: Link Rect: 326, 385, 335, 393 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 543, 375, 552, 383 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 528, 343, 537, 351 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 345, 291, 354, 299 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 328, 197, 337, 205 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 496, 197, 505, 205 Flags: Print Destination: 248 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 98, 76, 107, 84 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 109, 76, 118, 84 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 478, 86, 487, 94 Flags: Print Destination: 248 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 134, 339, 143, 346 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 265, 328, 274, 336 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 276, 328, 285, 336 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 90, 318, 99, 326 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 101, 318, 110, 326 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 120, 307, 129, 315 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 131, 307, 140, 315 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 206, 307, 215, 315 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 132, 286, 141, 294 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 77, 203, 86, 210 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 88, 203, 97, 210 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 255, 203, 264, 210 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 147, 182, 156, 190 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 208, 161, 217, 169 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 73, 119, 81, 127 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 362, 339, 371, 346 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 309, 265, 318, 273 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 321, 265, 330, 273 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 332, 265, 341, 273 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 386, 244, 395, 252 Flags: Print Destination: 248 Annotation: Subtype: Link Rect: 325, 213, 334, 221 Flags: Print Destination: 248 Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 329, 115, 338, 123 Flags: Print Destination: 248 Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 322, 449, 547, 455 Flags: Print Annotation: Subtype: Link Rect: 322, 441, 552, 447 Flags: Print Annotation: Subtype: Link Rect: 322, 433, 434, 439 Flags: Print Annotation: Subtype: Link Rect: 322, 425, 555, 431 Flags: Print Annotation: Subtype: Link Rect: 322, 417, 542, 423 Flags: Print Annotation: Subtype: Link Rect: 322, 409, 541, 415 Flags: Print Annotation: Subtype: Link Rect: 322, 401, 554, 407 Flags: Print Annotation: Subtype: Link Rect: 322, 393, 555, 399 Flags: Print Annotation: Subtype: Link Rect: 322, 385, 551, 391 Flags: Print Annotation: Subtype: Link Rect: 322, 377, 538, 383 Flags: Print Annotation: Subtype: Link Rect: 322, 369, 554, 375 Flags: Print Annotation: Subtype: Link Rect: 322, 361, 546, 367 Flags: Print Annotation: Subtype: Link Rect: 322, 353, 535, 359 Flags: Print Annotation: Subtype: Link Rect: 322, 345, 515, 351 Flags: Print Annotation: Subtype: Link Rect: 322, 337, 555, 343 Flags: Print Annotation: Subtype: Link Rect: 322, 329, 456, 336 Flags: Print Annotation: Subtype: Link Rect: 322, 321, 542, 328 Flags: Print Annotation: Subtype: Link Rect: 322, 313, 553, 320 Flags: Print Annotation: Subtype: Link Rect: 322, 305, 555, 312 Flags: Print Annotation: Subtype: Link Rect: 322, 297, 536, 304 Flags: Print Annotation: Subtype: Link Rect: 322, 289, 455, 296 Flags: Print Annotation: Subtype: Link Rect: 322, 281, 550, 288 Flags: Print Annotation: Subtype: Link Rect: 322, 273, 522, 280 Flags: Print Annotation: Subtype: Link Rect: 322, 265, 551, 272 Flags: Print Annotation: Subtype: Link Rect: 322, 257, 490, 264 Flags: Print Annotation: Subtype: Link Rect: 322, 249, 555, 256 Flags: Print Annotation: Subtype: Link Rect: 322, 241, 491, 248 Flags: Print Annotation: Subtype: Link Rect: 322, 233, 555, 240 Flags: Print Annotation: Subtype: Link Rect: 322, 226, 554, 232 Flags: Print Annotation: Subtype: Link Rect: 322, 218, 420, 224 Flags: Print Annotation: Subtype: Link Rect: 323, 210, 548, 216 Flags: Print Annotation: Subtype: Link Rect: 323, 202, 473, 208 Flags: Print Annotation: Subtype: Link Rect: 323, 194, 543, 200 Flags: Print Annotation: Subtype: Link Rect: 323, 186, 541, 192 Flags: Print Annotation: Subtype: Link Rect: 323, 178, 355, 184 Flags: Print Annotation: Subtype: Link Rect: 323, 170, 538, 176 Flags: Print Annotation: Subtype: Link Rect: 323, 162, 513, 168 Flags: Print Annotation: Subtype: Link Rect: 323, 154, 536, 160 Flags: Print Annotation: Subtype: Link Rect: 323, 146, 547, 152 Flags: Print Annotation: Subtype: Link Rect: 323, 138, 553, 144 Flags: Print Annotation: Subtype: Link Rect: 323, 130, 465, 136 Flags: Print Annotation: Subtype: Link Rect: 323, 122, 538, 128 Flags: Print Annotation: Subtype: Link Rect: 323, 114, 555, 120 Flags: Print Annotation: Subtype: Link Rect: 323, 106, 540, 112 Flags: Print Annotation: Subtype: Link Rect: 323, 98, 555, 104 Flags: Print Annotation: Subtype: Link Rect: 323, 90, 530, 96 Flags: Print Annotation: Subtype: Link Rect: 323, 82, 552, 88 Flags: Print Annotation: Subtype: Link Rect: 323, 74, 554, 80 Flags: Print Annotation: Subtype: Link Rect: 323, 66, 427, 73 Flags: Print Annotation: Subtype: Link Rect: 323, 58, 555, 65 Flags: Print Annotation: Subtype: Link Rect: 323, 50, 551, 57 Flags: Print Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 54, 732, 282, 738 Flags: Print Annotation: Subtype: Link Rect: 54, 724, 116, 730 Flags: Print Annotation: Subtype: Link Rect: 54, 716, 256, 722 Flags: Print Annotation: Subtype: Link Rect: 54, 708, 273, 714 Flags: Print Annotation: Subtype: Link Rect: 54, 700, 168, 706 Flags: Print Annotation: Subtype: Link Rect: 54, 692, 286, 698 Flags: Print Annotation: Subtype: Link Rect: 54, 684, 272, 690 Flags: Print Annotation: Subtype: Link Rect: 54, 676, 279, 682 Flags: Print Annotation: Subtype: Link Rect: 54, 668, 286, 674 Flags: Print Annotation: Subtype: Link Rect: 54, 660, 280, 666 Flags: Print Annotation: Subtype: Link Rect: 54, 652, 93, 658 Flags: Print Annotation: Subtype: Link Rect: 54, 644, 286, 651 Flags: Print Annotation: Subtype: Link Rect: 54, 636, 255, 643 Flags: Print Annotation: Subtype: Link Rect: 54, 628, 286, 635 Flags: Print Annotation: Subtype: Link Rect: 54, 620, 272, 627 Flags: Print Annotation: Subtype: Link Rect: 54, 612, 158, 619 Flags: Print Annotation: Subtype: Link Rect: 54, 604, 267, 611 Flags: Print Annotation: Subtype: Link Rect: 54, 596, 286, 603 Flags: Print Annotation: Subtype: Link Rect: 54, 588, 286, 595 Flags: Print Annotation: Subtype: Link Rect: 54, 580, 78, 587 Flags: Print Annotation: Subtype: Link Rect: 54, 572, 286, 579 Flags: Print Annotation: Subtype: Link Rect: 54, 565, 286, 571 Flags: Print Annotation: Subtype: Link Rect: 54, 557, 286, 563 Flags: Print Annotation: Subtype: Link Rect: 54, 549, 226, 555 Flags: Print Annotation: Subtype: Link Rect: 54, 541, 286, 547 Flags: Print Annotation: Subtype: Link Rect: 54, 533, 285, 539 Flags: Print Annotation: Subtype: Link Rect: 54, 525, 280, 531 Flags: Print Annotation: Subtype: Link Rect: 54, 517, 100, 523 Flags: Print Annotation: Subtype: Link Rect: 54, 509, 273, 515 Flags: Print Annotation: Subtype: Link Rect: 54, 501, 285, 507 Flags: Print Annotation: Subtype: Link Rect: 54, 493, 285, 499 Flags: Print Annotation: Subtype: Link Rect: 54, 485, 221, 491 Flags: Print Annotation: Subtype: Link Rect: 54, 477, 269, 483 Flags: Print Annotation: Subtype: Link Rect: 54, 469, 285, 475 Flags: Print Annotation: Subtype: Link Rect: 54, 461, 280, 467 Flags: Print Annotation: Subtype: Link Rect: 54, 453, 263, 459 Flags: Print Annotation: Subtype: Link Rect: 54, 445, 153, 451 Flags: Print Annotation: Subtype: Link Rect: 54, 437, 280, 443 Flags: Print Annotation: Subtype: Link Rect: 54, 429, 263, 435 Flags: Print Annotation: Subtype: Link Rect: 54, 421, 274, 427 Flags: Print Annotation: Subtype: Link Rect: 54, 413, 264, 419 Flags: Print Annotation: Subtype: Link Rect: 54, 405, 278, 411 Flags: Print Annotation: Subtype: Link Rect: 54, 397, 280, 403 Flags: Print Annotation: Subtype: Link Rect: 54, 389, 286, 396 Flags: Print Annotation: Subtype: Link Rect: 54, 381, 275, 388 Flags: Print Annotation: Subtype: Link Rect: 54, 373, 86, 380 Flags: Print Annotation: Subtype: Link Rect: 54, 365, 286, 372 Flags: Print Annotation: Subtype: Link Rect: 54, 357, 286, 364 Flags: Print Annotation: Subtype: Link Rect: 54, 349, 256, 356 Flags: Print Annotation: Subtype: Link Rect: 54, 341, 286, 348 Flags: Print Annotation: Subtype: Link Rect: 54, 333, 286, 340 Flags: Print Annotation: Subtype: Link Rect: 54, 325, 266, 332 Flags: Print Annotation: Subtype: Link Rect: 54, 317, 231, 324 Flags: Print Annotation: Subtype: Link Rect: 54, 309, 278, 316 Flags: Print Annotation: Subtype: Link Rect: 54, 301, 279, 308 Flags: Print Annotation: Subtype: Link Rect: 54, 294, 286, 300 Flags: Print Annotation: Subtype: Link Rect: 54, 286, 235, 292 Flags: Print Annotation: Subtype: Link Rect: 54, 278, 278, 284 Flags: Print Annotation: Subtype: Link Rect: 54, 270, 276, 276 Flags: Print Annotation: Subtype: Link Rect: 54, 262, 253, 268 Flags: Print Annotation: Subtype: Link Rect: 54, 254, 284, 260 Flags: Print Annotation: Subtype: Link Rect: 54, 246, 284, 252 Flags: Print Annotation: Subtype: Link Rect: 54, 238, 272, 244 Flags: Print Annotation: Subtype: Link Rect: 54, 230, 195, 236 Flags: Print Annotation: Subtype: Link Rect: 54, 222, 256, 228 Flags: Print Annotation: Subtype: Link Rect: 54, 214, 281, 220 Flags: Print Annotation: Subtype: Link Rect: 54, 206, 264, 212 Flags: Print Annotation: Subtype: Link Rect: 54, 198, 229, 204 Flags: Print Annotation: Subtype: Link Rect: 54, 190, 286, 196 Flags: Print Annotation: Subtype: Link Rect: 54, 182, 275, 188 Flags: Print Annotation: Subtype: Link Rect: 323, 732, 555, 738 Flags: Print Annotation: Subtype: Link Rect: 323, 724, 347, 730 Flags: Print Annotation: Subtype: Link Rect: 323, 716, 540, 722 Flags: Print Annotation: Subtype: Link Rect: 323, 708, 555, 714 Flags: Print Annotation: Subtype: Link Rect: 323, 700, 555, 706 Flags: Print Annotation: Subtype: Link Rect: 323, 692, 444, 698 Flags: Print Annotation: Subtype: Link Rect: 323, 684, 555, 690 Flags: Print Annotation: Subtype: Link Rect: 323, 676, 555, 682 Flags: Print Annotation: Subtype: Link Rect: 323, 668, 423, 674 Flags: Print Annotation: Subtype: Link Rect: 323, 660, 532, 666 Flags: Print Annotation: Subtype: Link Rect: 323, 652, 555, 658 Flags: Print Annotation: Subtype: Link Rect: 323, 644, 433, 651 Flags: Print Annotation: Subtype: Link Rect: 323, 636, 543, 643 Flags: Print Annotation: Subtype: Link Rect: 323, 628, 554, 635 Flags: Print Annotation: Subtype: Link Rect: 323, 620, 545, 627 Flags: Print Annotation: Subtype: Link Rect: 323, 612, 348, 619 Flags: Print Annotation: Subtype: Link Rect: 323, 604, 541, 611 Flags: Print Annotation: Subtype: Link Rect: 323, 596, 474, 603 Flags: Print Annotation: Subtype: Link Rect: 323, 588, 555, 595 Flags: Print Annotation: Subtype: Link Rect: 323, 580, 555, 587 Flags: Print Annotation: Subtype: Link Rect: 323, 572, 382, 579 Flags: Print Annotation: Subtype: Link Rect: 323, 565, 542, 571 Flags: Print Annotation: Subtype: Link Rect: 323, 557, 533, 563 Flags: Print Annotation: Subtype: Link Rect: 323, 549, 519, 555 Flags: Print Annotation: Subtype: Link Rect: 323, 541, 555, 547 Flags: Print Annotation: Subtype: Link Rect: 323, 533, 527, 539 Flags: Print Annotation: Subtype: Link Rect: 323, 525, 355, 531 Flags: Print Annotation: Subtype: Link Rect: 323, 517, 546, 523 Flags: Print Annotation: Subtype: Link Rect: 323, 509, 525, 515 Flags: Print Annotation: Subtype: Link Rect: 323, 501, 542, 507 Flags: Print Annotation: Subtype: Link Rect: 323, 493, 550, 499 Flags: Print Annotation: Subtype: Link Rect: 323, 485, 462, 491 Flags: Print Annotation: Subtype: Link Rect: 323, 477, 554, 483 Flags: Print Annotation: Subtype: Link Rect: 323, 469, 550, 475 Flags: Print Annotation: Subtype: Link Rect: 323, 461, 554, 467 Flags: Print Annotation: Subtype: Link Rect: 323, 453, 555, 459 Flags: Print Annotation: Subtype: Link Rect: 323, 445, 386, 451 Flags: Print Annotation: Subtype: Link Rect: 323, 437, 524, 443 Flags: Print Annotation: Subtype: Link Rect: 323, 429, 541, 435 Flags: Print Annotation: Subtype: Link Rect: 323, 421, 537, 427 Flags: Print Annotation: Subtype: Link Rect: 323, 413, 549, 419 Flags: Print Annotation: Subtype: Link Rect: 323, 405, 551, 411 Flags: Print Annotation: Subtype: Link Rect: 323, 397, 555, 403 Flags: Print Annotation: Subtype: Link Rect: 323, 389, 554, 396 Flags: Print Annotation: Subtype: Link Rect: 323, 381, 509, 388 Flags: Print Annotation: Subtype: Link Rect: 323, 373, 543, 380 Flags: Print Annotation: Subtype: Link Rect: 323, 365, 552, 372 Flags: Print Annotation: Subtype: Link Rect: 323, 357, 547, 364 Flags: Print Annotation: Subtype: Link Rect: 323, 349, 400, 356 Flags: Print Annotation: Subtype: Link Rect: 323, 341, 538, 348 Flags: Print Annotation: Subtype: Link Rect: 323, 333, 552, 340 Flags: Print Annotation: Subtype: Link Rect: 323, 325, 333, 332 Flags: Print Annotation: Subtype: Link Rect: 469, 294, 544, 300 Flags: Print Annotation: Subtype: Link Rect: 323, 286, 380, 292 Flags: Print Annotation: Subtype: Link Rect: 323, 278, 542, 284 Flags: Print Annotation: Subtype: Link Rect: 323, 270, 555, 276 Flags: Print Annotation: Subtype: Link Rect: 323, 262, 475, 268 Flags: Print Annotation: Subtype: Link Rect: 323, 254, 555, 260 Flags: Print Annotation: Subtype: Link Rect: 323, 246, 538, 252 Flags: Print Annotation: Subtype: Link Rect: 323, 238, 552, 244 Flags: Print Annotation: Subtype: Link Rect: 323, 230, 369, 236 Flags: Print Annotation: Subtype: Link Rect: 323, 222, 531, 228 Flags: Print Annotation: Subtype: Link Rect: 323, 214, 531, 220 Flags: Print Annotation: Subtype: Link Rect: 323, 206, 544, 212 Flags: Print Annotation: Subtype: Link Rect: 323, 198, 435, 204 Flags: Print Checksum: a217fa3b Type: CRC32 Checksum: 691ceed1ce06e4f5651258bd363778d9 Type: MD5 Checksum: 76bc83d2a6bce3c503e82ddbfaa8415ab0f69385 Type: SHA-1 Checksum: 996531adebeafecfddc40ba5bee10eff2bdee2f8b4be4d197f873b85a44f0249 Type: SHA-256