93d96206d5e8ff478919dfb3c47b3346  308688.pdf
69344878494e23140c5049bdd4a7803ea476f231  308688.pdf
20a06b64b6e560f7e6f73930c3d9237741de479b6c3207b6ab57537285a955b6  308688.pdf

Title:           Response to amoxicillin and perampanel in infantile Alexander disease
Creator:         Adobe InDesign 19.5 (Windows)
Producer:        Adobe PDF Library 17.0
CreationDate:    Tue Dec  3 03:32:23 2024 CET
ModDate:         Tue Dec  3 03:32:24 2024 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           5
Encrypted:       no
Page size:       595.276 x 782.362 pts
Page rot:        0
File size:       1721040 bytes
Optimized:       yes
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
LJXNPH+STIXTwoText-Italic            Type 1C           Custom           yes yes yes    250  0
ZMYTDF+STIXTwoText                   Type 1C           Custom           yes yes yes    251  0
GHIJXR+STIXTwoText-Bold              Type 1C           Custom           yes yes yes    252  0
ZMYTDF+STIXTwoText                   Type 1C           Custom           yes yes yes    158  0
ZMYTDF+STIXTwoText                   Type 1C           Custom           yes yes yes    159  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-03-08 02:38:43 CET
 RepresentationInformation: 308688.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-03-07 13:41:52 CET
  Size: 1721040
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 266
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseNone
    Language: en-US
    Outlines: 
     Item: 
      Title: Response to amoxicillin and perampanel in infantile Alexander disease
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: 1  |  INTRODUCTION
       Item: 
        Title: 2  |  CASE REPORT
       Item: 
        Title: 3  |  DISCUSSION
       Item: 
        Title: 4  |  CONCLUSIONS
       Item: 
        Title: AUTHOR CONTRIBUTIONS
       Item: 
        Title: CONFLICT OF INTEREST STATEMENT
       Item: 
        Title: DATA AVAILABILITY STATEMENT
       Item: 
        Title: ETHICS STATEMENT
       Item: 
        Title: ORCID
       Item: 
        Title: REFERENCES
   Info: 
    Title: Response to amoxicillin and perampanel in infantile Alexander disease
    Creator: Adobe InDesign 19.5 (Windows)
    Producer: Adobe PDF Library 17.0
    CreationDate: Tue Dec 03 04:02:23 CET 2024
    ModDate: Tue Dec 03 04:02:24 CET 2024
   ID: 0x895063ffe2146944b97318ff96195f06, 0xe6f5a01a98a19923af251fea7c6b1ade
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 951
      ImageHeight: 148
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 3137
      ImageHeight: 1925
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 951
      ImageHeight: 148
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 951
      ImageHeight: 148
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 951
      ImageHeight: 148
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: LJXNPH+STIXTwoText-Italic
      FontSubset: true
      FirstChar: 1
      LastChar: 127
      FontDescriptor: 
       FontName: LJXNPH+STIXTwoText-Italic
       Flags: Serif, Symbolic, Italic
       FontBBox: -893, -367, 1298, 1047
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ZMYTDF+STIXTwoText
      FontSubset: true
      FirstChar: 1
      LastChar: 179
      FontDescriptor: 
       FontName: ZMYTDF+STIXTwoText
       Flags: Serif, Symbolic
       FontBBox: -948, -373, 1297, 1047
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GHIJXR+STIXTwoText-Bold
      FontSubset: true
      FirstChar: 1
      LastChar: 173
      FontDescriptor: 
       FontName: GHIJXR+STIXTwoText-Bold
       Flags: Serif, Symbolic
       FontBBox: -948, -434, 1429, 1047
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.4-c005 78.147326, 2012/08/23-13:03:03 ">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about=""
xmlns:xmp="http://ns.adobe.com/xap/1.0/"
xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
xmlns:jav="http://www.niso.org/schemas/jav/1.0/" 
xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
<jav:journal_article_version>VoR</jav:journal_article_version>
<prism:doi>10.1002/epi4.13077</prism:doi>
<pdfx:WPS-ARTICLEDOI>10.1002/epi4.13077</pdfx:WPS-ARTICLEDOI>
<pdfx:WPS-JOURNALDOI>10.1002/(ISSN)2470-9239</pdfx:WPS-JOURNALDOI>
<pdfx:WPS-PROCLEVEL>3</pdfx:WPS-PROCLEVEL> 
<dc:title>
<rdf:Alt>
<rdf:li xml:lang="x-default">Response to amoxicillin and perampanel in infantile Alexander disease</rdf:li>
</rdf:Alt>
</dc:title>
</rdf:Description>
</rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 2505
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 409, 37, 516, 27
      Annotation: 
       Subtype: Link
       Rect: 132, 608, 136, 586
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 273, 608, 277, 586
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 277, 602, 289, 590
      Annotation: 
       Subtype: Link
       Rect: 408, 608, 412, 586
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 412, 602, 425, 590
      Annotation: 
       Subtype: Link
       Rect: 170, 590, 174, 568
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 286, 590, 290, 568
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 432, 590, 432, 568
      Annotation: 
       Subtype: Link
       Rect: 432, 590, 436, 568
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 436, 584, 448, 572
      Annotation: 
       Subtype: Link
       Rect: 152, 568, 156, 551
       ActionDest: 198
      Annotation: 
       Subtype: Link
       Rect: 156, 566, 169, 554
      Annotation: 
       Subtype: Link
       Rect: 199, 77, 372, 67
      Annotation: 
       Subtype: Link
       Rect: 68, 369, 135, 358
    Page: 
     Label: 2506
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 81, 346, 84, 332
       ActionDest: 49
      Annotation: 
       Subtype: Link
       Rect: 246, 320, 249, 306
       ActionDest: 49
      Annotation: 
       Subtype: Link
       Rect: 72, 294, 75, 280
       ActionDest: 49
      Annotation: 
       Subtype: Link
       Rect: 66, 242, 70, 228
       ActionDest: 49
      Annotation: 
       Subtype: Link
       Rect: 70, 216, 74, 202
       ActionDest: 49
      Annotation: 
       Subtype: Link
       Rect: 82, 203, 86, 189
       ActionDest: 49
      Annotation: 
       Subtype: Link
       Rect: 90, 177, 94, 163
       ActionDest: 49
      Annotation: 
       Subtype: Link
       Rect: 378, 60, 383, 46
       ActionDest: 21
    Page: 
     Label: 2507
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 238, 203, 242, 189
       ActionDest: 49
      Annotation: 
       Subtype: Link
       Rect: 284, 190, 287, 176
       ActionDest: 49
      Annotation: 
       Subtype: Link
       Rect: 97, 138, 101, 124
       ActionDest: 49
      Annotation: 
       Subtype: Link
       Rect: 90, 99, 94, 85
       ActionDest: 49
      Annotation: 
       Subtype: Link
       Rect: 203, 86, 206, 72
       ActionDest: 49
      Annotation: 
       Subtype: Link
       Rect: 339, 307, 342, 293
       ActionDest: 49
      Annotation: 
       Subtype: Link
       Rect: 523, 242, 527, 228
       ActionDest: 121
      Annotation: 
       Subtype: Link
       Rect: 470, 216, 477, 202
       ActionDest: 121
      Annotation: 
       Subtype: Link
       Rect: 338, 203, 345, 189
       ActionDest: 121
      Annotation: 
       Subtype: Link
       Rect: 319, 151, 326, 137
       ActionDest: 121
      Annotation: 
       Subtype: Link
       Rect: 422, 112, 439, 98
       ActionDest: 121
    Page: 
     Label: 2508
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 198, 710, 214, 696
       ActionDest: 121
      Annotation: 
       Subtype: Link
       Rect: 146, 619, 161, 605
       ActionDest: 121
      Annotation: 
       Subtype: Link
       Rect: 71, 593, 78, 579
       ActionDest: 121
      Annotation: 
       Subtype: Link
       Rect: 153, 580, 156, 566
       ActionDest: 49
      Annotation: 
       Subtype: Link
       Rect: 204, 554, 211, 540
       ActionDest: 121
      Annotation: 
       Subtype: Link
       Rect: 247, 541, 254, 527
       ActionDest: 121
      Annotation: 
       Subtype: Link
       Rect: 102, 515, 108, 501
       ActionDest: 121
      Annotation: 
       Subtype: Link
       Rect: 72, 411, 78, 397
       ActionDest: 121
      Annotation: 
       Subtype: Link
       Rect: 204, 398, 211, 384
       ActionDest: 121
      Annotation: 
       Subtype: Link
       Rect: 226, 177, 233, 163
       ActionDest: 121
      Annotation: 
       Subtype: Link
       Rect: 393, 555, 406, 542
      Annotation: 
       Subtype: Link
       Rect: 406, 554, 462, 540
      Annotation: 
       Subtype: Link
       Rect: 307, 541, 413, 527
      Annotation: 
       Subtype: Link
       Rect: 378, 529, 391, 516
      Annotation: 
       Subtype: Link
       Rect: 391, 528, 447, 514
      Annotation: 
       Subtype: Link
       Rect: 307, 515, 415, 501
      Annotation: 
       Subtype: Link
       Rect: 394, 503, 406, 490
      Annotation: 
       Subtype: Link
       Rect: 406, 502, 462, 488
      Annotation: 
       Subtype: Link
       Rect: 307, 489, 413, 475
      Annotation: 
       Subtype: Link
       Rect: 389, 477, 401, 464
      Annotation: 
       Subtype: Link
       Rect: 401, 476, 457, 462
      Annotation: 
       Subtype: Link
       Rect: 307, 463, 413, 449
      Annotation: 
       Subtype: Link
       Rect: 434, 377, 541, 365
      Annotation: 
       Subtype: Link
       Rect: 393, 342, 515, 330
      Annotation: 
       Subtype: Link
       Rect: 523, 308, 550, 296
      Annotation: 
       Subtype: Link
       Rect: 324, 296, 465, 284
      Annotation: 
       Subtype: Link
       Rect: 423, 216, 534, 204
      Annotation: 
       Subtype: Link
       Rect: 523, 170, 550, 158
      Annotation: 
       Subtype: Link
       Rect: 324, 158, 450, 146
      Annotation: 
       Subtype: Link
       Rect: 324, 101, 487, 89
    Page: 
     Label: 2509
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 221, 738, 287, 726
      Annotation: 
       Subtype: Link
       Rect: 61, 726, 175, 714
      Annotation: 
       Subtype: Link
       Rect: 232, 634, 287, 622
      Annotation: 
       Subtype: Link
       Rect: 61, 623, 166, 611
      Annotation: 
       Subtype: Link
       Rect: 61, 577, 201, 565
      Annotation: 
       Subtype: Link
       Rect: 61, 301, 218, 289
      Annotation: 
       Subtype: Link
       Rect: 384, 657, 547, 645
      Annotation: 
       Subtype: Link
       Rect: 391, 611, 514, 599
      Annotation: 
       Subtype: Link
       Rect: 444, 565, 548, 553
      Annotation: 
       Subtype: Link
       Rect: 322, 554, 344, 542
      Annotation: 
       Subtype: Link
       Rect: 383, 496, 538, 484
      Annotation: 
       Subtype: Link
       Rect: 322, 450, 448, 438
      Annotation: 
       Subtype: Link
       Rect: 422, 342, 520, 328
      Annotation: 
       Subtype: Link
       Rect: 318, 329, 362, 315
  Checksum: 5bba283e
   Type: CRC32
  Checksum: 93d96206d5e8ff478919dfb3c47b3346
   Type: MD5
  Checksum: 69344878494e23140c5049bdd4a7803ea476f231
   Type: SHA-1
  Checksum: 20a06b64b6e560f7e6f73930c3d9237741de479b6c3207b6ab57537285a955b6
   Type: SHA-256