5708a71564aa937045548533e91f2e65 308691.pdf e3464aecc2b4048746ee548b849adf6105ef2207 308691.pdf 90da98093a21ccf89d8d6fe9a4150477379741094ff6ce8f316aab22d2bd1a8b 308691.pdf Title: Impact of Dietary Niacin on Metabolic Dysfunction-Associated Steatotic Liver Disease in Mediterranean Subjects: A Population-Based Study Subject: Background: The impact of dietary niacin on metabolic dysfunction-associated steatotic liver disease (MASLD) is elusive. This sub-study aimed to investigate the relationship between dietary niacin intake and the presence of MASLD in participants from two Catalonian cohorts. Methods: A total of 222 subjects with MASLD were age- and sex-matched to 222 non-MASLD subjects. Dietary nutrients were analyzed using a validated food frequency questionnaire (FFQ). Dietary niacin and other nutrients were adjusted for total energy intake. MASLD was defined by a Fatty Liver Index (FLI) of >60 and by having at least one component of metabolic syndrome. The association between niacin intake (distributed into tertiles) and the presence of MASLD was assessed using multivariate logistic regression. Potential non-linear relationships were also analyzed through restricted cubic spline regression (RCS). Results: Our data revealed that subjects with MASLD had worse metabolic profiles. The dietary intake of niacin did not differ between subjects with and without MASLD. Even after adjusting for different confounding variables, i.e., sociodemographic variables, smoking status, physical activity, and cardiometabolic comorbidities, no significant associations were observed between higher intakes of niacin (tertiles 2 and 3) and the presence of MASLD: odds ratio (95% confidence) second tertile: 0.99 (0.89–1.09); third tertile: 0.98 (0.89–1.10). However, RCS analysis uncovered a significant non-linear dose-response association between dietary niacin intake and odds of MASLD. Specifically, such analysis revealed that MASLD risk was decreased in subjects with niacin intake values of <35 mg/day. Conclusions: Our data showed that dietary niacin intake was associated with lower odds of MASLD in a Mediterranean population; however, our logistic regression analysis failed to reveal significant associations between the intake of niacin and the risk of MASLD. Further research is warranted to establish a causal relationship between dietary niacin interventions and MASLD. Keywords: hepatic steatosis; vitamin B3; niacin; tryptophan; fatty liver; case-control study Author: Maria Antentas, Marina Idalia Rojo-López, Pau Vendrell, Minerva Granado-Casas, Idoia Genua, Berta Fernandez-Camins, Joana Rossell, Julia Niño-Narvión, Estefanía Moreira, Esmeralda Castelblanco, Emilio Ortega, Bogdan Vlacho, Nuria Alonso, Didac Mauricio and Josep Julve Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Mon Dec 2 10:09:41 2024 CET ModDate: Mon Dec 2 10:12:03 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1787641 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- YWWVQQ+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 BRDHXL+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 AKOUOQ+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 CAXVGE+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 YQMKHR+VnURWPalladioL Type 1 Custom yes yes yes 32 0 PDTLUH+CMSY10 Type 1 Builtin yes yes yes 65 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 76 0 HPPDBM+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 90 0 HPPDCN+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 96 0 HPPDCO+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 102 0 HPPDCP+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 108 0 HPPDDA+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 111 0 HPPDDB+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 114 0 HPPEBM+PalatinoLinotype-Roman TrueType MacRoman yes yes no 117 0 HPPDBM+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 125 0 HPPDCN+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 131 0 HPPDCO+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 137 0 HPPDCP+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 143 0 HPPDDA+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 146 0 HPPDDB+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 149 0 HPPEBM+PalatinoLinotype-Roman TrueType MacRoman yes yes no 152 0 HPPDBM+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 163 0 HPPDCN+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 169 0 HPPDCO+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 175 0 HPPDCP+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 181 0 HPPDDA+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 184 0 HPPDDB+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 187 0 HPPEBM+PalatinoLinotype-Roman TrueType MacRoman yes yes no 190 0 HPPDBM+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 201 0 HPPDCN+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 207 0 HPPDCO+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 213 0 HPPDCP+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 219 0 HPPDDA+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 222 0 HPPDDB+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 225 0 HPPEBM+PalatinoLinotype-Roman TrueType MacRoman yes yes no 228 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-03-11 02:43:04 CET RepresentationInformation: 308691.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-03-10 13:46:00 CET Size: 1787641 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 517 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Study Design and Settings Destination: subsection.2.1 Item: Title: Participants Destination: subsection.2.2 Item: Title: Variables Destination: subsection.2.3 Item: Title: Dietary Niacin Consumption Destination: subsection.2.4 Item: Title: Dietary Macronutrient Consumption Destination: subsection.2.5 Item: Title: Statistical Analysis Destination: subsection.2.6 Item: Title: Results Destination: section.3 Children: Item: Title: Dietary Intake Destination: subsection.3.1 Item: Title: Association Analysis Between Dietary Niacin and MASLD Destination: subsection.3.2 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: appendix.A. Info: Title: Impact of Dietary Niacin on Metabolic Dysfunction-Associated Steatotic Liver Disease in Mediterranean Subjects: A Population-Based Study Author: Maria Antentas, Marina Idalia Rojo-López, Pau Vendrell, Minerva Granado-Casas, Idoia Genua, Berta Fernandez-Camins, Joana Rossell, Julia Niño-Narvión, Estefanía Moreira, Esmeralda Castelblanco, Emilio Ortega, Bogdan Vlacho, Nuria Alonso, Didac Mauricio and Josep Julve Subject: Background: The impact of dietary niacin on metabolic dysfunction-associated steatotic liver disease (MASLD) is elusive. This sub-study aimed to investigate the relationship between dietary niacin intake and the presence of MASLD in participants from two Catalonian cohorts. Methods: A total of 222 subjects with MASLD were age- and sex-matched to 222 non-MASLD subjects. Dietary nutrients were analyzed using a validated food frequency questionnaire (FFQ). Dietary niacin and other nutrients were adjusted for total energy intake. MASLD was defined by a Fatty Liver Index (FLI) of >60 and by having at least one component of metabolic syndrome. The association between niacin intake (distributed into tertiles) and the presence of MASLD was assessed using multivariate logistic regression. Potential non-linear relationships were also analyzed through restricted cubic spline regression (RCS). Results: Our data revealed that subjects with MASLD had worse metabolic profiles. The dietary intake of niacin did not differ between subjects with and without MASLD. Even after adjusting for different confounding variables, i.e., sociodemographic variables, smoking status, physical activity, and cardiometabolic comorbidities, no significant associations were observed between higher intakes of niacin (tertiles 2 and 3) and the presence of MASLD: odds ratio (95% confidence) second tertile: 0.99 (0.89 1.09); third tertile: 0.98 (0.89 1.10). However, RCS analysis uncovered a significant non-linear dose-response association between dietary niacin intake and odds of MASLD. Specifically, such analysis revealed that MASLD risk was decreased in subjects with niacin intake values of <35 mg/day. Conclusions: Our data showed that dietary niacin intake was associated with lower odds of MASLD in a Mediterranean population; however, our logistic regression analysis failed to reveal significant associations between the intake of niacin and the risk of MASLD. Further research is warranted to establish a causal relationship between dietary niacin interventions and MASLD. 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