0af625bff4323637b35b059988cb7b46 309018.pdf 6cbd877896db7bafff17342e8a2ec58d456415bd 309018.pdf 54f5e53911b058f0408ba2c871e240d0d670096f89fa4fede348358049a0bfc6 309018.pdf Title: Effectiveness of the 23-Valent Pneumococcal Polysaccharide Vaccine (PPV23) in Preventing Community-Acquired Pneumonia in Adults: A Population-Based Cohort Study Subject: Aim: The aim was to assess the effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) in preventing CAP in adults. Methods: This was a population-based cohort study, followed up over 5 years (2015–2019), that included 47,768 persons aged 18 years assigned to three primary care centres. Data were retrospectively obtained from electronic medical records and databases. The vaccination effect was adjusted for potential confounders. Analyses were performed for the entire study population and for the 65 age subgroup. Results: The annual incidence of CAP (per 103 adult inhabitants) was 3.29 overall, and 8.08 and 2.93 for vaccinated and non-vaccinated persons, respectively. The non-adjusted effect of PPV23 on CAP was evidenced by HR = 2.80 (95% CI: 2.32–3.37), and after adjusting for possible confounders, PPV23 showed no significant independent effect on CAP in the overall population (HR = 1.14; p = 0.277) or in persons aged 65 years (HR = 1.30; p = 0.051). No protective effect was observed in persons vaccinated <2 years previously (HR = 1.17; p = 0.514). Conclusions: PPV23 showed no effect in preventing CAP in adults aged 18 years or in the subgroup aged 65 years, even if vaccinated <2 years previously. Keywords: community-acquired pneumonia; vaccination; PPV23; prevention; effectiveness Author: Mateu Serra-Prat, Ignasi Bolíbar, Elisabet Palomera, Àngel Lavado and Jordi Almirall Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Mon Sep 9 08:24:18 2024 CEST ModDate: Mon Sep 9 08:27:06 2024 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 251177 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FWNTIM+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 BHPCUF+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 WTEOIH+URWPalladioL-Roma Type 1 Custom yes yes yes 22 0 ERRFKU+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 EILUJF+CMSY10 Type 1 Builtin yes yes yes 32 0 SBMXUO+VnURWPalladioL Type 1 Custom yes yes yes 37 0 URYLRZ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 70 0 SYVAVM+VnURWPalladioL-Italic Type 1 Custom yes yes yes 87 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-03-20 02:44:45 CET RepresentationInformation: 309018.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-03-19 13:32:56 CET Size: 251177 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 194 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Methodology Destination: section.2 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: References Destination: appendix.A. Info: Title: Effectiveness of the 23-Valent Pneumococcal Polysaccharide Vaccine (PPV23) in Preventing Community-Acquired Pneumonia in Adults: A Population-Based Cohort Study Author: Mateu Serra-Prat, Ignasi Bolíbar, Elisabet Palomera, Àngel Lavado and Jordi Almirall Subject: Aim: The aim was to assess the effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) in preventing CAP in adults. Methods: This was a population-based cohort study, followed up over 5 years (2015 2019), that included 47,768 persons aged 18 years assigned to three primary care centres. Data were retrospectively obtained from electronic medical records and databases. The vaccination effect was adjusted for potential confounders. Analyses were performed for the entire study population and for the 65 age subgroup. Results: The annual incidence of CAP (per 103 adult inhabitants) was 3.29 overall, and 8.08 and 2.93 for vaccinated and non-vaccinated persons, respectively. The non-adjusted effect of PPV23 on CAP was evidenced by HR = 2.80 (95% CI: 2.32 3.37), and after adjusting for possible confounders, PPV23 showed no significant independent effect on CAP in the overall population (HR = 1.14; p = 0.277) or in persons aged 65 years (HR = 1.30; p = 0.051). No protective effect was observed in persons vaccinated <2 years previously (HR = 1.17; p = 0.514). Conclusions: PPV23 showed no effect in preventing CAP in adults aged 18 years or in the subgroup aged 65 years, even if vaccinated <2 years previously. 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