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Title:           Small Extracellular Vesicles in the Pericardium Modulate Macrophage Immunophenotype in Coronary Artery Disease
Subject:         JACC: Basic to Translational Science, 9 (2024) 1057-1072. doi:10.1016/j.jacbts.2024.05.003
Author:          Soumaya Ben-Aicha PhD
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      Title: Small Extracellular Vesicles in the Pericardium Modulate Macrophage Immunophenotype in Coronary Artery Disease
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       Item: 
        Title: Methods
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          Title: Sample collection and characterization
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           Item: 
            Title: Study design
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            Title: Pericardial cells and fluid isolation
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          Title: Macrophage characterization
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           Item: 
            Title: sEV preparation and characterization
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          Title: In vitro macrophage immunoprofiling
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           Item: 
            Title: Preparation of macrophages from buffy coats and exposure to pericardial sEVs
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            Title: Macrophage (Mϕ) quantitative polymerase chain reaction analysis
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          Title: Macrophages functional assays
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         Item: 
          Title: miRNAs target gene analysis
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           Item: 
            Title: sEV miRNA analyses by small RNA sequencing
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            Title: In silico analysis
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            Title: miR-6516-5p targets investigation in macrophages
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          Title: Statistics
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           Item: 
            Title: Sample size
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        Title: Results
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         Item: 
          Title: Pericardial anti-inflammatory macrophage phenotype is reduced in CAD patients
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         Item: 
          Title: PF-sEV purity confirmation and quantification
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          Title: PF- sEV profile
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         Item: 
          Title: PF- CAD sEVs reduce the anti-inflammatory profile on in vitro Mϕ
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         Item: 
          Title: PF-CAD sEVs reduce the GATA6+ MΦ population
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          Title: Regulation of scavenger receptors and lipid uptake in cultured macrophages stimulated with PF-sEV
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          Title: miR6516-5p target genes on macrophages
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        Title: Discussion
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         Item: 
          Title: PF sEV Mϕ immunomodulatory capacity
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          Title: PF-sEV-miRNA functional cargo
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          Title: Study limitations
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        Title: Conclusions
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        Title: Funding Support and Author Disclosures
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        Title: References
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   Type: CRC32
  Checksum: 2b0a220860224e71aebd44d510faa1ba
   Type: MD5
  Checksum: f66d09f1aa9c7812277c2fcd6cbc255a096c47f4
   Type: SHA-1
  Checksum: 0100bf26d24d9bd73a09d5f637f2403fb88604d85653902dc4fd5b3f556d3fbf
   Type: SHA-256