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Title: Abstract Destination: section*.2 Item: Title: 1 | BACKGROUND Destination: section..1.1 Item: Title: 2 | METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Subjects and samples Destination: subsection..1.2.1 Item: Title: 2.2 | Bisulfite treatment and Illumina Infinium bead array Destination: subsection..1.2.2 Item: Title: 2.3 | Microarray QC and data normalization Destination: subsection..1.2.3 Item: Title: 2.4 | Data analysis Destination: subsection..1.2.4 Item: Title: 2.5 | Overlap with genetic variants identified from CSF biomarker GWAS Destination: subsection..1.2.5 Item: Title: 2.6 | Assessment of plasma YKL-40 protein levels Destination: subsection..1.2.6 Item: Title: 2.7 | Weighted gene correlation network analysis (WGCNA) Destination: subsection..1.2.7 Item: Title: 2.8 | Data and code availability Destination: subsection..1.2.8 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | EWAS on disease status Destination: subsection..1.3.1 Item: Title: 3.2 | EWAS on CSF tau variables Destination: subsection..1.3.2 Item: Title: 3.3 | EWAS on CSF amyloid measures Destination: subsection..1.3.3 Item: Title: 3.4 | EWAS on other disease-relevant CSF biomarkers Destination: subsection..1.3.4 Item: Title: 3.5 | Eight DMRs overlap between different CSF biomarker analyses Destination: subsection..1.3.5 Item: Title: 3.6 | Overlap with GWAS results from AD biomarker analyses Destination: subsection..1.3.6 Item: Title: 3.7 | Relationship of YKL-40 blood DNA methylation with plasma protein levels Destination: subsection..1.3.7 Item: Title: 3.8 | Blood DNA co-methylation networks associated with CSF biomarker measurements Destination: subsection..1.3.8 Item: Title: 4 | DISCUSSION Destination: section..1.4 Item: Title: AFFILIATIONS Destination: section*.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.6 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.8 Item: Title: CONSENT STATEMENT Destination: section*.10 Item: 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